公开(公告)号：BR0107921A

公开(公告)日：2002-10-22

申请号：BR0107921

申请日：2001-02-01

Applicant: PROCTER & GAMBLE

Inventor： CAZER FREDRICK DANA ,  PERRY GREGORY EUGENE ,  BILLINGS DENNIS MICHAEL ,  REDMAN-FUREY NACY LEE

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

公开(公告)号：NO20023645D0

公开(公告)日：2002-07-31

申请号：NO20023645

申请日：2002-07-31

Applicant: PROCTER & GAMBLE

Inventor： CAZER FREDERICK DANA ,  PARRY GREGORY EUGENE ,  BILLINGS DENNIS MICHAEL ,  REDMAN-FUREY NANCY LEE

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58 ,  C07F

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.

公开(公告)号：UY26766A1

公开(公告)日：2002-01-31

申请号：UY26766

申请日：2001-06-13

Applicant: BOEHRINGER INGELHEIM PHARMA

Inventor： MUELLER-BOETTICHER DR HERMANN ,  BRESSLER GERD-RAINER ,  KREYE DR PAUL

IPC: C07D211/72 ,  C07D201/00

Abstract: El invento se refiere a un procedimiento aplicable a escala técnica para la separación dinámica entre enantiómeros de derivados de piperidona con la fórmula general (1) en la que R1, R2, R3 y n pueden tener los significados mencionados en la memoria descriptiva y en las reivindiciones, mediando simultánea racemización in situ del enantiómero que no haya reaccionado.

公开(公告)号：TR9800403A2

公开(公告)日：1998-09-21

申请号：TR9800403

申请日：1998-03-06

Applicant: HOFFMANN LA ROCHE

Inventor： ABRECHT STEFAN

IPC: C07D463/00 ,  B01J27/08 ,  C07B61/00 ,  C07D207/26 ,  C07D207/273 ,  C07D498/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/56 ,  C07D505/00 ,  C07D507/08 ,  C07D201/00

CPC classification number: C07D207/273 ,  C07D501/00 ,  C07D505/00

公开(公告)号：ITMI910953A1

公开(公告)日：1992-10-06

申请号：ITMI910953

申请日：1991-04-05

Applicant: CONSIGLIO NAZIONALE RICERCHE

Inventor： CASADEI MARIA ANTONIETTA ,  INESI ACHILLE ,  MICHELETTI MORACCI FRANCO

IPC: C07D20060101 ,  C07D201/00

公开(公告)号：ITMI910953D0

公开(公告)日：1991-04-05

申请号：ITMI910953

申请日：1991-04-05

Applicant: CONSIGLIO NAZIONALE RICERCHE

Inventor： CASADEI MARIA ANTONIETTA ,  INESI ACHILLE ,  MICHELETTI MORACCI FRANCO

IPC: C07D20060101 ,  C07D201/00

公开(公告)号：PT83334A

公开(公告)日：1986-10-01

申请号：PT8333486

申请日：1986-09-09

Applicant: CIBA GEIGY AG

IPC: C07D205/08 ,  C07D205/09 ,  C07D499/00 ,  C07D499/88 ,  C07D201/00

Abstract: An improved process for the preparation of compounds of the formula … … or salts thereof, starting from compounds of the formulae … … via compounds of the formulae … … in which compounds R1 represent hydrogen or lower alkyl, R2 represents an organic radical which may carry a functional group which is unprotected or protected by a customary protecting group R, R3 represents hydrogen or a customary carboxyl protecting group R, W represents a group exchangeable for a thiocarboxyl radical of the formula III and Z represents oxygen or sulphur.

公开(公告)号：PT82143A

公开(公告)日：1986-04-01

申请号：PT8214386

申请日：1986-03-05

Applicant: BAYER AG

Inventor： SCHMIDT GUNTER ,  ZEILER HANS-JOACHIM ,  METZGER KARL GEORG

IPC: A23K20/195 ,  A61K31/43 ,  A61K31/45 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D499/00 ,  C07D499/10 ,  C07D499/12 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70 ,  C07D501/06 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/57 ,  C07D501/59 ,  C07D501/00 ,  C07D201/00

Abstract: Antibacterially active and animal growth-promoting novel beta -lactam compounds of the formula in which R1 represents the radical Y representing N or CR9, or Y-R7 representing >C=O or >C=N-R7, Z representing O, S, or NR10, and R2 represents hydrogen or a protective group.

公开(公告)号：IE842667L

公开(公告)日：1985-04-18

申请号：IE266784

申请日：1984-10-17

Applicant: DROPIC SOC CIV ILE DE GESTION ,  IND CHOAY

IPC: C07D201/00 ,  C07D211/00 ,  C07D223/00

公开(公告)号：HU184777B

公开(公告)日：1984-10-29

申请号：HU136580

申请日：1980-05-30

Applicant: CHEVRON RES

Inventor： CHEONG KING CHAN DAVID

IPC: A01N20060101 ,  A01N39/00 ,  A01N43/06 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  C07C20060101 ,  C07D20060101 ,  C07D201/00 ,  C07D207/12 ,  C07D207/14 ,  C07D207/24 ,  C07D207/26 ,  C07D207/273 ,  C07D207/38 ,  C07D307/00 ,  C07D307/20 ,  C07D307/22 ,  C07D307/30 ,  C07D307/32 ,  C07D325/00 ,  C07D333/00 ,  C07D333/22 ,  C07D333/30 ,  C07D333/32 ,  C07D333/36 ,  C07D407/12 ,  C07D409/12