公开(公告)号：US20220235476A1

公开(公告)日：2022-07-28

申请号：US17582409

申请日：2022-01-24

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Yang LIU

IPC: C25B11/093 ,  C25B1/04

Abstract: Disclosed is a catalyst for hydrogen evolution reaction (HER) including: a first transition metal matrix; and a second transition metal oxide formed on the first transition metal matrix; wherein a hydroxyl group is introduced on the second transition metal oxide.

公开(公告)号：US20220220483A1

公开(公告)日：2022-07-14

申请号：US17614795

申请日：2020-06-01

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： V. Narry KIM ,  Jinah YEO ,  Dongwan KIM ,  Young-Suk LEE ,  Soo-Jin JUNG

IPC: C12N15/113 ,  A61K31/713 ,  A61P31/22 ,  C12N9/12 ,  C12Q1/70

Abstract: The present invention relates to a technology for preventing or treating virus infection and infectious disease by inducing a mixed tailing regarding an RNA virus.

公开(公告)号：US11359245B2

公开(公告)日：2022-06-14

申请号：US16889372

申请日：2020-06-01

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Keetae Kim ,  Hong Gil Nam ,  Chand Parvez Danka Mohammed

IPC: C12Q1/6883 ,  C12N15/113 ,  G01N33/50 ,  G01N33/68

Abstract: The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.

公开(公告)号：US20220169591A1

公开(公告)日：2022-06-02

申请号：US17534789

申请日：2021-11-24

Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyoyoung LEE ,  Thi Kim Chau NGUYEN ,  Jinsun LEE

IPC: C07C68/04 ,  B01J21/06 ,  B01J35/00 ,  B01J23/30 ,  B01J23/50

Abstract: Provided is a preparing method of linear carbonate compounds, including performing a coupling reaction of carbon dioxide in the presence of a titanium dioxide complex. The titanium dioxide complex includes an anatase phase and a rutile phase, a reduced titanium dioxide which is formed by selectively reducing any one of the anatase phase and the rutile phase, and a metallic oxide bound to the reduced titanium dioxide.

公开(公告)号：US11344872B2

公开(公告)日：2022-05-31

申请号：US16959880

申请日：2019-01-02

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Seung Youn Hong ,  Yoon Su Park ,  Yeongyu Hwang ,  Yeong Bum Kim

IPC: C07F15/06 ,  C07F17/02 ,  B01J31/22 ,  C07D207/267 ,  C07D209/46 ,  C07D209/52 ,  C07D209/54 ,  C07D209/56 ,  C07D209/70 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07J43/00

Abstract: The present invention relates to a novel metal complex, a method for producing same, and a method for producing a gamma-lactam compound using same, and the metal complex according to the present invention is used as a catalyst for producing a gamma-lactam compound and can efficiently produce a gamma-lactam compound with an excellent yield and excellent selectivity.

公开(公告)号：US20220163400A1

公开(公告)日：2022-05-26

申请号：US17606279

申请日：2019-10-17

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Je Geun PARK ,  Ha Leem KIM ,  Matthew John COAK

IPC: G01K1/14 ,  G01K1/02 ,  G01K13/00 ,  G01K7/34

Abstract: Provided is a probe system for low-temperature high-precision heat transport measurement, the probe system including a sample loader where a sample is loaded. In the probe system for low-temperature high-precision heat transport measurement, the sample loader includes a first frame including a sample loading space, and a second frame including an open end coupled to the first frame to accommodate the sample loading space.

公开(公告)号：US20210369766A1

公开(公告)日：2021-12-02

申请号：US17285253

申请日：2019-07-29

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sin-Hyeog IM ,  Verma RAVI ,  Changhon LEE

IPC: A61K31/736 ,  C12N5/0783 ,  C08B37/00 ,  A61K36/06 ,  A61K35/17 ,  A61P1/00 ,  A61P29/00 ,  A23L33/125 ,  A23L33/145

Abstract: The present invention relates to a yeast-derived polysaccharide inducing Treg cells and a use thereof and, more particularly, to a polysaccharide comprising mannan and β-glucan, an composition for immunomodulation comprising the polysaccharide as an active ingredient, a pharmaceutical composition or food comprising the polysaccharide as an active ingredient for prevention or treatment of immune disease or inflammatory disease, a method for preparation of regulatory T cells by using the polysaccharide, a cell therapeutic agent comprising the regulatory T cells prepared by the preparation method as an active ingredient, and a treatment method using same. Even at a low dose, the novel polysaccharide according to the present invention allows the production of tolerogenic antigen presenting cells through the β-glucan and mannan structure retained therein, whereby the novel polysaccharide can induce the differentiation or production of antigen-specific regulatory T cells (Treg cells) to modulate the target immune system with low adverse effects. Therefore, MGCP and the Treg cells induced by the polysaccharide are effective for preventing or treating immune disease or inflammatory disease.

公开(公告)号：US11185596B2

公开(公告)日：2021-11-30

申请号：US15541784

申请日：2016-01-06

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dong Wook Kim ,  Jin Soo Kim ,  Chul Yong Park ,  Duk Hyoung Kim ,  Jung Eun Kim ,  Jiyeon Kweon

IPC: A61K48/00 ,  A61K35/54 ,  C12N5/074 ,  C12N15/11 ,  C12N9/22 ,  C07K14/755 ,  C12N15/113 ,  A61K35/12 ,  A61K35/545

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

公开(公告)号：US20210363527A1

公开(公告)日：2021-11-25

申请号：US17385277

申请日：2021-07-26

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： V. Narry KIM ,  Haedong KIM ,  Jimi KIM

IPC: C12N15/113 ,  C12Q1/6886 ,  G01N33/68

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising miR-324 and TUT4/7 expression modulators, wherein the pharmaceutical composition of the present invention can prevent cell division and hinder cancer development by inhibiting the function of TUT4/7, and can increase the amount of miR-324-5p and suppress the function of miR-324-3p.1, and therefore can be effectively used for prevention, treatment, or diagnosis of cancer.

公开(公告)号：US20210340554A1

公开(公告)日：2021-11-04

申请号：US17366320

申请日：2021-07-02

Applicant: INSTITUTE FOR BASIC SCIENCE ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  AICT

Inventor： Jin Soo KIM ,  Jungeun KIM ,  Sunghwa CHOE ,  Je Wook WOO ,  Soon Il KWON ,  Hyeran KIM

IPC: C12N15/82 ,  C12N9/22 ,  C12N15/11

Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.