公开(公告)号：WO2008153277A1

公开(公告)日：2008-12-18

申请号：PCT/KR2008/002715

申请日：2008-05-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SONG, Soo-Chang ,  PARK, Mi-Ran ,  LEE, Sun-Mi

Inventor： SONG, Soo-Chang ,  PARK, Mi-Ran ,  LEE, Sun-Mi

IPC: C08G79/02

CPC classification number: A61K31/56 ,  A61K9/06 ,  A61K31/7052 ,  A61K47/34 ,  C08G65/33306 ,  C08G79/025 ,  C08G2650/50 ,  C08L2203/02

Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

Abstract translation: 提供具有官能团的可生物降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。

公开(公告)号：WO2008150074A2

公开(公告)日：2008-12-11

申请号：PCT/KR2008/002806

申请日：2008-05-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  JUNG, Sang Hoon ,  LEE, Eun Ha ,  PAN, Cheol-Ho ,  KIM, Chul Young ,  UM, Byung Hun ,  LEE, Dong-Un ,  SONG, Dae Geun ,  LEE, Joo Young

Inventor： JUNG, Sang Hoon ,  LEE, Eun Ha ,  PAN, Cheol-Ho ,  KIM, Chul Young ,  UM, Byung Hun ,  LEE, Dong-Un ,  SONG, Dae Geun ,  LEE, Joo Young

IPC: A61K36/22 ,  A61K31/34 ,  A61P3/00

CPC classification number: A61K36/22 ,  A61K31/34

Abstract: The present invention relates to a composition for prevention and treatment of diabetic complications containing the extracts of Rhus verniciflua, fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition for prevention and treatment of diabetic complications which comprises the extracts of Rhus verniciflua extracted by using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom as an active ingredient. The extracts of Rhus verniciflua extracted by- using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom were confirmed to have inhibitory effect on aldose reductase causing accumulation of sorbitol which is one of major causes of diabetic complications and on advanced glycation end procuct without cytotoxicity, so that they were confirmed to be safe materials effectively used for the composition for prevention and treatment of diabetic complications.

Abstract translation: 本发明涉及一种预防和治疗含有紫荆提取物及其分离物及其分离自其中的化合物作为活性成分的糖尿病并发症的组合物，更准确地说，涉及预防和治疗糖尿病并发症的组合物，其包含紫草提取物 通过使用水，醇或其混合物作为溶剂萃取，其馏分和作为活性成分从其中分离出的化合物。 通过使用水，醇或其混合物作为溶剂提取的Rhus verniciflua的提取物，其级分和从其分离的化合物被证实对引起糖尿病并发症的主要原因之一的山梨糖醇积累的醛糖还原酶具有抑制作用，并且对 晚期糖基化终末没有细胞毒性，因此被证实是有效用于预防和治疗糖尿病并发症的组合物的安全材料。

公开(公告)号：WO2008130181A1

公开(公告)日：2008-10-30

申请号：PCT/KR2008/002283

申请日：2008-04-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KWON, Ick-Chan ,  CHOI, Kui-Won ,  KIM, Kwang-Meyung ,  YOUN, In-Chan ,  KIM, Jong-Ho ,  PARK, Kyeong-Soon

Inventor： KWON, Ick-Chan ,  CHOI, Kui-Won ,  KIM, Kwang-Meyung ,  YOUN, In-Chan ,  KIM, Jong-Ho ,  PARK, Kyeong-Soon

IPC: A61K49/12

CPC classification number: A61K41/0071 ,  A61K47/61 ,  A61K47/6929

Abstract: Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizer for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.

Abstract translation: 公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。 用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。 光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。 由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。 因此，缀合物作为用于光动力疗法的光敏剂是非常有用的，其具有降低的副作用和优异的治疗有效性。

公开(公告)号：WO2008111818A1

公开(公告)日：2008-09-18

申请号：PCT/KR2008/001459

申请日：2008-03-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  AHN, Dae-Ro ,  YANG, Eun Gyeong

Inventor： AHN, Dae-Ro ,  YANG, Eun Gyeong

IPC: C12Q1/68

CPC classification number: G01N33/68 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10 ,  C12Q1/682 ,  C12Q1/6823 ,  G01N2500/00 ,  C12Q2525/205 ,  C12Q2525/161 ,  C12Q2521/301 ,  C12Q2565/1015

Abstract: A method and a kit for detecting a target protein in a sample with a signal amplification strategy are provided. The signal amplification strategy is established for the aptamer-based molecular recognition of a target protein with concomitant release of single-stranded DNA (G-DNA), which binds complementarily to a single-stranded RNA comprising a fluorophore and a quencher ("F-RNA-Q"). The fluorescence-quenched RNA is then degraded by RNase H to result in a fluorescence signal, and the undamaged G-DNA is recycled to yield fluorescence amplification.

Abstract translation: 提供了一种利用信号放大策略检测样品中靶蛋白的方法和试剂盒。 建立信号放大策略，用于靶蛋白的适体分子识别，并伴随释放单链DNA（G-DNA），其与包含荧光团和猝灭剂的单链RNA互补结合（“F- RNA-Q“）。 然后荧光淬灭的RNA被RNase H降解以产生荧光信号，并且未损坏的G-DNA被再循环以产生荧光扩增。

公开(公告)号：WO2008093920A2

公开(公告)日：2008-08-07

申请号：PCT/KR2007/003198

申请日：2007-07-02

Applicant: DONGBU HITEK CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PAE, Ae Nim ,  CHO, Yong Seo ,  CHOO, Hyunah ,  CHA, Joo Hwan ,  KIM, Ji Hye ,  KOH, Hun Yeong ,  PARK, Woo-Kyu ,  KONG, Jae Yang ,  CHAE, Myeong Yun ,  CHO, Insun ,  HWANG, Bong Woon ,  LEE, Dong Ha

Inventor： PAE, Ae Nim ,  CHO, Yong Seo ,  CHOO, Hyunah ,  CHA, Joo Hwan ,  KIM, Ji Hye ,  KOH, Hun Yeong ,  PARK, Woo-Kyu ,  KONG, Jae Yang ,  CHAE, Myeong Yun ,  CHO, Insun ,  HWANG, Bong Woon ,  LEE, Dong Ha

IPC: C07D401/12

CPC classification number: C07D237/32

Abstract: The present invention relates to a novel 1,2-dihydro-1-oxophthalazinyl piperazine compound having biological activity as serotonin receptor antagonist, a preparation method of the compound and a pharmaceutical composition for the treatment and prevention of central nervous system diseases comprising the compound.

Abstract translation: 本发明涉及具有生物活性作为血清素受体拮抗剂的新型1,2-二氢-1-氧代嗪嗪哌嗪化合物，该化合物的制备方法和用于治疗和预防包含该化合物的中枢神经系统疾病的药物组合物。

公开(公告)号：WO2008088154A1

公开(公告)日：2008-07-24

申请号：PCT/KR2008/000225

申请日：2008-01-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KWON, Soon-Il

Inventor： KWON, Soon-Il

IPC: B25J13/00

CPC classification number: B25J13/003 ,  G10L17/06

Abstract: An apparatus for identifying a user in a service robot for domestic use is provided, the apparatus comprising a feature vector classifying unit for classifying feature vectors converted from a user voice signal for statistics into a feature vector not causing a user identification error and a feature vector causing the user identification error to thereby set user modes corresponding to the respective feature vectors for each user, and an identifying unit for identifying the user by utilizing the classification result of the feature vector classifying unit as data for the user identification. Accordingly, time restriction caused when the service robot for domestic use identifies who a user is can be overcome, and, the degradation of the user identification due to the lack of absolutely needed data amount when the user is identified only by the user's short voice can be solved.

Abstract translation: 提供了一种用于识别用于家用服务机器人中的用户的装置，该装置包括特征向量分类单元，用于将从用户统计的用户语音信号转换的特征向量分类为不导致用户识别错误的特征向量和特征向量 导致用户识别错误，从而设置对应于每个用户的各个特征向量的用户模式，以及识别单元，用于通过利用特征向量分类单元的分类结果作为用户标识的数据来识别用户。 因此，当用于家庭用的服务机器人识别谁可以克服用户时，引起的时间限制，并且当用户仅通过用户的短语音识别用户时，由于缺少绝对需要的数据量而导致用户识别的恶化 要解决

公开(公告)号：WO2008044803A1

公开(公告)日：2008-04-17

申请号：PCT/KR2006/004130

申请日：2006-10-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Byung-Chul ,  MOON, Sung-Wook

Inventor： LEE, Byung-Chul ,  MOON, Sung-Wook

IPC: H01L21/20 ,  H01L21/306 ,  H01L21/027

CPC classification number: H01L21/76838 ,  B81C1/00111 ,  B81C1/00634 ,  H01L21/32134 ,  H01L21/76876 ,  H01L2221/1094 ,  H05K3/062 ,  H05K3/244 ,  H05K2203/0361 ,  H05K2203/073

Abstract: Disclosed herein is a method for manufacturing a metal structure and carbon nanotubes by immersion plating. The method comprises forming a first metal layer of first metal on a substrate, immersion plating a portion of the first metal layer with second metal from the surface of the first metal layer to a predetermined depth in a predetermined region of the first metal layer, to form a second metal layer of the second metal, and etching one selected from the first metal layer and the second metal layer.

Abstract translation: 本文公开了一种通过浸镀法制造金属结构和碳纳米管的方法。 该方法包括在基板上形成第一金属的第一金属层，将第一金属层的第一金属层的一部分从第一金属层的表面浸渍到第一金属层的预定区域中的预定深度，至 形成第二金属的第二金属层，并蚀刻从第一金属层和第二金属层中选择的一个。

公开(公告)号：WO2008030072A1

公开(公告)日：2008-03-13

申请号：PCT/KR2007/004364

申请日：2007-09-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  HANMI PHARM. CO., LTD. ,  KIM, Dong Chan ,  KIM, Dong Jin ,  YOO, Kyung Ho ,  SHIN, Kye Jung ,  BYEON, Seong Rim ,  LEE, Gwan Sun ,  KIM, Maeng Sup ,  AHN, Young Gil ,  MOOK, Inhee

Inventor： KIM, Dong Chan ,  KIM, Dong Jin ,  YOO, Kyung Ho ,  SHIN, Kye Jung ,  BYEON, Seong Rim ,  LEE, Gwan Sun ,  KIM, Maeng Sup ,  AHN, Young Gil ,  MOOK, Inhee

IPC: C07D213/34

CPC classification number: C07D213/38 ,  C07D213/30

Abstract: The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.

Abstract translation: 本发明涉及一种有效抑制脑中β-淀粉样蛋白原纤维形成的新型化合物及其制备方法，以及含有作为活性成分的药物组合物。

公开(公告)号：WO2008029969A1

公开(公告)日：2008-03-13

申请号：PCT/KR2006/005282

申请日：2006-12-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KANG, Sung Chul ,  KIM, Munsang ,  KIM, Seung Jong ,  YUN, Seung Kook ,  YOO, Jeonghoon

Inventor： KANG, Sung Chul ,  KIM, Munsang ,  KIM, Seung Jong ,  YUN, Seung Kook ,  YOO, Jeonghoon

IPC: B25J17/02

CPC classification number: B25J19/0004 ,  Y10T74/20329

Abstract: The present invention provides a device for generating and varying stiffness, which may be applied to a joint of a robot manipulator. The stiffness generating device of the present invention, comprises: a rotating shaft connected to a driven member; a rotor fixed to the rotating shaft and having arms comprising a magnetic element; a stator disposed to surround the rotor outside the arms and being connected to a drive motor; electromagnets fixed to an inner periphery of the stator and being opposed to each other about the rotating shaft, each having a core and a coil wound around the core; and means for applying current to the coils. One half of the electromagnets has N-poles at their inward ends and the other half of the electromagnets has S-poles at their inward ends. Current regulating means regulates the current being applied to the coils.

Abstract translation: 本发明提供一种用于产生和改变刚度的装置，其可以应用于机器人操纵器的接头。 本发明的刚度产生装置包括：连接到从动构件的旋转轴; 固定在旋转轴上并具有包括磁性元件的臂的转子; 定子，其被布置成围绕所述转子在所述臂外围并连接到驱动电动机; 电磁体固定在定子的内周并且围绕旋转轴彼此相对，每个具有缠绕在芯上的芯和线圈; 以及用于向线圈施加电流的装置。 电磁体的一半在其内端具有N极，另一半的电磁体在其内端具有S极。 电流调节装置调节施加到线圈的电流。

公开(公告)号：WO2008026803A1

公开(公告)日：2008-03-06

申请号：PCT/KR2006/005361

申请日：2006-12-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Jong-Ho ,  LEE, Hae-Weon ,  KIM, Joo-Sun ,  SONG, Hue-Sup ,  SON, Ji-Won ,  KIM, Hae-Ryoung ,  KIM, Hyoung-Chul ,  KIM, Sung-Moon ,  JUNG, Hwa-Young

Inventor： LEE, Jong-Ho ,  LEE, Hae-Weon ,  KIM, Joo-Sun ,  SONG, Hue-Sup ,  SON, Ji-Won ,  KIM, Hae-Ryoung ,  KIM, Hyoung-Chul ,  KIM, Sung-Moon ,  JUNG, Hwa-Young

IPC: H01M8/02

CPC classification number: H01M8/0282 ,  C03C8/14 ,  C03C8/18 ,  C03C8/24 ,  H01M8/0286 ,  H01M8/2425 ,  H01M8/2432 ,  H01M2008/1293

Abstract: A composite sealant of the present invention increases a fracture toughness of glass which has an excellent gas tightness but has a low fracture resistance, to enhance the thermal cycle stability while maintaining the gas tightness of a stack. For this, alpha-alumina fiber particles, alpha-alumina granular particles, and metallic particles are mixed and added to a glass matrix for remarkably increasing the fracture toughness from 0.5 MPa • m05 to 6 MPa • m°'5 through the multiple effects of crack deflection and crack bridging by the fiber and granular particles, and effects of crack arresting and plastic deformation by the metallic particles. When using the high fracture toughness composite sealant of the present invention, since the gas tightness and the stability of the stack can be maintained even when there is a thermal stress produced by a non-uniform temperature distribution or a thermal cycle condition in the stack, increasing the fracture toughness of the composite sealant works as the most important factor for enhancing the reliability of a large-area stack.

Abstract translation: 本发明的复合密封剂提高了具有优异的气密性但具有低抗断裂性的玻璃的断裂韧性，以提高热循环的稳定性，同时保持了叠层的气密性。 为此，将α-氧化铝纤维颗粒，α-氧化铝颗粒和金属颗粒混合并添加到玻璃基质中，通过裂纹偏转的多重作用将断裂韧性从0.5MPa m05显着增加到6MPa m°5 并通过纤维和颗粒颗粒裂缝桥接，以及金属颗粒的裂纹停止和塑性变形的作用。 当使用本发明的高断裂韧性复合密封剂时，即使当堆叠中存在由不均匀的温度分布或热循环条件产生的热应力时，由于能够保持气密性和堆叠的稳定性， 提高复合密封胶的断裂韧性是提高大面积叠层可靠性的最重要因素。