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    A SUPERHYDROPHOBIC AEROGEL THAT DOES NOT REQUIRE PER-FLUORO COMPOUNDS OR CONTAIN ANY FLUORINE
    241.
    发明公开
    A SUPERHYDROPHOBIC AEROGEL THAT DOES NOT REQUIRE PER-FLUORO COMPOUNDS OR CONTAIN ANY FLUORINE 有权
    一种不需要全氟化合物或含有任何氟的超疏水性气凝胶

    公开(公告)号：EP2294152A2

    公开(公告)日：2011-03-16

    申请号：EP09774310.8

    申请日：2009-06-30

    Applicant: STC.UNM

    Inventor： KISSEL, David, J. ,  BRINKER, Charles, Jeffrey

    IPC: C09D183/02 ,  C09D5/00 ,  C09K3/18

    CPC classification number: C09D183/02 ,  C08K3/36 ,  C08K7/26 ,  C08K9/06 ,  C09D5/14 ,  C09D5/1687 ,  C09D7/62 ,  C09K3/18 ,  Y10T428/24975 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249986 ,  Y10T428/24999 ,  Y10T428/249991 ,  Y10T442/20 ,  Y10T442/218 ,  Y10T442/2279 ,  Y10T442/2525 ,  Y10T442/259

    Abstract: Provided are superhydrophobic coatings, devices and articles including superhydrophobic coatings, and methods for preparing the superhydrophobic coatings. The exemplary superhydrophobic device can include a substrate component and one or more superhydrophobic coatings disposed over the substrate component, wherein at least one of the one or more superhydrophobic coatings has a water contact angle of at least about 150° and a contact angle hysteresis of less than about 1°. The one or more superhydrophobic coatings can include an ultra high water content acid catalyzed polysilicate gel, the polysilicate gel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

    Abstract translation: 提供了超疏水涂层，包括超疏水涂层的装置和制品，以及制备超疏水涂层的方法。 示例性的超疏水性装置可以包括基体组分和设置在基体组件上的一个或多个超疏水性涂层，其中所述一种或多种超疏水性涂层中的至少一个具有至少约150°的水接触角和较小的接触角滞后 大约1°。 所述一种或多种超疏水涂层可包含超高含水量酸催化聚硅酸盐凝胶，所述聚硅酸盐凝胶包含具有用甲硅烷基化试剂衍生的表面官能团和多个孔隙的二氧化硅颗粒的三维网络。

    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME
    242.
    发明公开
    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME 审中-公开
    根据上述制造集成超声图像传感器和工艺治疗超声头片

    公开(公告)号：EP2254476A2

    公开(公告)日：2010-12-01

    申请号：EP09716644.1

    申请日：2009-02-27

    Applicant: STC.UNM

    Inventor： CHEN, Jingkuang

    IPC: A61B8/00

    CPC classification number: B06B1/0292

    Abstract: A therapeutic ultrasound device may include a substrate, at least one high power capacitive micromachined ultrasonic transducer, and at least one imager transducer comprising a capacitive micromachined ultrasonic transducer. The at least one high power capacitive micromachined ultrasonic transducer and the imager transducer may be monolithically integrated on the substrate.

    PHOTOACOUSTIC IMAGING DEVICES AND METHODS OF IMAGING
    243.
    发明公开
    PHOTOACOUSTIC IMAGING DEVICES AND METHODS OF IMAGING 有权
    PHOTO的声学成像设备和成像方法的

    公开(公告)号：EP2231019A1

    公开(公告)日：2010-09-29

    申请号：EP08860441.8

    申请日：2008-12-10

    Applicant: STC.UNM

    Inventor： CHEN, Jingkuang

    IPC: A61B8/00

    CPC classification number: A61B5/0095 ,  A61B5/0086 ,  A61B5/02007 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/028 ,  Y10T29/49826

    Abstract: A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

    SUPPRESSIVE MACROPHAGES, C-REACTIVE PROTEIN AND THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND IMMUNE THROMBOCYTOPENIC PURPURA
    244.
    发明公开
    SUPPRESSIVE MACROPHAGES, C-REACTIVE PROTEIN AND THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND IMMUNE THROMBOCYTOPENIC PURPURA 审中-公开
    抑制巨噬细胞，C反应蛋白和免疫治疗系统性红斑狼疮和血小板减少性紫癜

    公开(公告)号：EP2097087A2

    公开(公告)日：2009-09-09

    申请号：EP07867365.4

    申请日：2007-11-06

    Applicant: STC.UNM

    Inventor： DU CLOS, Terry W. ,  MOLD, Carolyn

    IPC: A61K35/14

    CPC classification number: A61K35/15 ,  A61K35/28 ,  A61K38/1745 ,  A61K2300/00

    Abstract: The present invention relates to the use of suppressive macrophage or dendritic cells (activated with C-reactive protein or CRP-related compounds), for the treatment of various disease states and conditions associated with immune thrombocytopenic purpura (ITP) and/or systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects, including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein. In another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition associated with systemic lupus erythematosus or ITP will have an outbreak is an additional aspect of the present invention. In the case of ITP, methods of the present invention are used to increase platelet counts in the treated patient. In addition, in the case of ITP, the present invention relates to the use of CRP or a CRP-related compound in the absence of suppressive macrophages for the treatment of ITP.

    ISOTOPE ENHANCED AMBROXOL FOR LONG LASTING AUTOPHAGY INDUCTION
    249.
    发明申请
    ISOTOPE ENHANCED AMBROXOL FOR LONG LASTING AUTOPHAGY INDUCTION 审中-公开

    公开(公告)号：WO2018148113A1

    公开(公告)日：2018-08-16

    申请号：PCT/US2018/016573

    申请日：2018-02-02

    Applicant: STC.UNM

    Inventor： TIMMINS, Graham ,  DERETIC, Vojo P.

    IPC: C07B59/00 ,  C07C213/08 ,  C07C215/68 ,  A61K31/136 ,  A61K51/04 ,  A61P11/00 ,  A61P31/04

    Abstract: The present invention is directed to 13 C and/or 2 H isotope enhanced ambroxol ("isotope enhanced ambroxol") and its use in the treatment of autophagy infections, especially mycobacterial and other infections, disease states and/or conditions of the lung, such as tuberculosis, especially including drug resistant and multiple drag resistant tuberculosis. Pharmaceutical compositions comprising isotope enhanced amhroxol, alone or in combination with an additional bioactive agent, especially rifamycin antibiotics, including an additional autophagy modulator (an agent which is active to promote or inhibit autophagy), thus being useful against, an autophagy mediated disease state and/or condition), especially an antophagy mediated disease state and/or condition which occurs in the lungs, for example, a Mycobacterium infection. Chronic Obstructive Pulmonary Disease (COPD), asthma, pulmonary fibrosis, cystic fibrosis, Sjogren's disease and lung cancer (small cell and non-small cell lung cancer, among other disease states and/or conditions, especially of the lung. Methods of treating autophagy disease states and/or conditions, especially including autophagy disease states or conditions which occur principally in the lungs of a patient represent a further embodiment of the present invention. An additional embodiment includes methods of synthesizing compounds according to the present invention as otherwise disclosed herein.

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