公开(公告)号：WO1993003773A1

公开(公告)日：1993-03-04

申请号：PCT/US1992003773

申请日：1992-05-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SIBLEY, Murray, Jack

IPC: A61L02/18

CPC classification number: A45C11/005

Abstract: A contact lens storage chamber (10) has a lens retaining member (15) disposed therein with baskets (20, 21) for containing the lenses disposed in a vertically juxtaposed manner. The lens retaining member has a stopper portion (16) which is located in an opening at the top of the chamber and is retained in place by a loose tongue-in-groove structure (17, 18) which facilitates the escape of vapors from the chamber during a lens cleaning and disinfecting procedure.

公开(公告)号：WO1993003751A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006944

申请日：1992-08-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FU LU, Mou-Ying ,  REILAND, Thomas, L.

IPC: A61K37/02

CPC classification number: A61K9/006 ,  A61K38/09 ,  A61K47/12 ,  A61K47/44

Abstract: Pharmaceutical compositions for the sublingual or buccal administration of therapeutic agents (particularly polypeptides) which are normally degraded upon oral administration comprise such a therapeutic agent, a solvent, optionally a cosolvent and/or hydrogel, and an oral mucosal membrane transport enhancing agent which is selected from the group consisting of essential and volatile oils and inorganic and organic acids.

Abstract translation: 口服给药通常降解的治疗剂（特别是多肽）的舌下或口腔给药的药物组合物包括这样的治疗剂，溶剂，任选的共溶剂和/或水凝胶，以及选择的口腔粘膜转运增强剂 由基本挥发油和无机和有机酸组成的组。

公开(公告)号：WO1993003344A2

公开(公告)日：1993-02-18

申请号：PCT/US1992006297

申请日：1992-07-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DUBLER, Robert, E. ,  GROTE, Jonathan ,  KUHN, Donna, R.

IPC: G01N0

CPC classification number: G01N33/533 ,  C07K16/44 ,  G01N33/9486 ,  Y10S436/815

Abstract: Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX). Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten. Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immuoassay for dextropropoxyphene and/or nordextropropoxyphene. Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.

公开(公告)号：WO1993002667A1

公开(公告)日：1993-02-18

申请号：PCT/US1992005923

申请日：1992-07-15

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GARREN, Kevin, W. ,  VADNERE, Madhu, K. ,  WIELAND, John, J. ,  LEVEQUE, Mary, Jo

IPC: A61K09/48

CPC classification number: A61K31/495 ,  A61K9/4858 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61K38/553 ,  C07D211/46 ,  C07D211/54 ,  C07D277/28 ,  C07D295/26 ,  C07K5/06078 ,  Y10S514/962 ,  Y10S530/80

Abstract: A pharmaceutical composition comprising a solution of a compound of formula (II) wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl; R3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH3S- or CH3SCH2-; R4 is loweralkyl or cyclopropyl; R5 is hydrogen or loweralkyl; and X is CH2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof in a pharmaceutically acceptable solvent, said solution being encapsulated in a soft elastic gelatin capsule.

Abstract translation: 一种药物组合物，其包含式（II）化合物的溶液，其中R 1是4-哌嗪基，1-甲基-4-哌嗪基，1-甲基-1-氧代-4-哌嗪基，2-氧代-4-哌嗪基，4 吗啉基，4-硫代吗啉基或1-甲基-4-高哌嗪基; R2是苄基，对甲氧基苄基，2-苯基乙基，1-萘基甲基或2-萘基甲基; R3是4-噻唑基，2-氨基-4-噻唑基，2-噻唑基，5-噻唑基，1-吡唑基，3-吡唑基，1-咪唑基，正丙基，异丙基，CH3S-或CH3SCH2-; R4是低级烷基或环丙基; R5是氢或低级烷基; X为CH 2或NH; 或其药学上可接受的盐，酯或前药在药学上可接受的溶剂中，所述溶液被包封在软弹性明胶胶囊中。

公开(公告)号：WO1993002037A1

公开(公告)日：1993-02-04

申请号：PCT/US1992005715

申请日：1992-07-07

Applicant: ABBOTT LABORATORIES ,  DELLARIA, Joseph, F. ,  BROOKS, Dee, W. ,  MOORE, Jimmie, L. ,  SALLIN, Kevin, J.

Inventor： ABBOTT LABORATORIES

IPC: C07C53/06

CPC classification number: C07D213/64 ,  C07C275/64 ,  C07C311/18 ,  C07C317/40 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07D207/34 ,  C07D215/48 ,  C07D277/56 ,  C07D307/68 ,  C07D307/85 ,  C07D333/20 ,  C07D333/38 ,  C07D333/70 ,  C07D405/12

Abstract: The present invention provides certain (substituted carbocyclic aryl)amidoalkyl- and (substituted heterocyclic aryl)amidoalkyl-N-Hydroxy urea compounds which inhibit lipoxygenase enzyme activity and are thus useful in the treatment of allergic and inflammatory disease states.

公开(公告)号：WO1993001739A1

公开(公告)日：1993-02-04

申请号：PCT/US1992006023

申请日：1992-07-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GARTMAN, Charles, Wayne

IPC: A47G19/00

CPC classification number: B01L3/50853 ,  B01L3/50825 ,  B01L9/06 ,  B65D71/50 ,  Y02W30/807

Abstract: A reusable seal assembly (12) for sealing a plurality of containers (15) arranged in close proximity to one another. The seal assembly (12) includes a subassembly comprising a pliable sealing component (21) having a plurality of spaced protrusions (26) positioned to seal openings (19) of the containers (15), and a substantially rigid supporting component (22) for supporting the sealing component (21) and for effecting the substantially simultaneous sealing of the openings (19) of the containers (15) by the plurality of protrusions (26) when the subassembly is mounted on the containers (15), and the substantially simultaneous withdrawal of the plurality of protrusions (26) from the openings (19) when the subassembly is removed from the containers (15). The seal assembly (12) also includes a shipping component (23) adapted to be mounted to the subassembly to strengthen the seal between the protrusions (26) and the containers (15) for use particularly during shipping of the containers (15) when rough treatment may be expected. The seal assembly (12) of the present invention is particularly designed to seal multi-vial, multi-dose reagent packs for clinical analyzer apparatus, and also includes a surface (42) thereon for carrying indicia (43) to identify a seal assembly (12) with its particular reagent pack.

Abstract translation: 一种用于密封彼此靠近地布置的多个容器（15）的可重复使用的密封组件（12）。 密封组件（12）包括一个子组件，该组件包括一个具有多个间隔开的突起（26）的密封部件（21），该突出部定位成密封容器（15）的开口（19），以及基本上刚性的支撑部件（22） 支撑所述密封部件（21）并且当所述子组件安装在所述容器（15）上时，通过所述多个突起部26实质上同时密封所述容器（15）的所述开口（19），并且基本上同时 当子组件从容器（15）移除时，多个突起（26）从开口（19）中撤出。 密封组件（12）还包括适于安装到子组件的运输组件（23），以加强突起（26）和容器（15）之间的密封，以在特别是在粗糙的运输容器（15）期间使用 可以预期治疗。 本发明的密封组件（12）特别设计用于密封用于临床分析仪装置的多小瓶多剂量试剂包，并且还包括其上用于承载标记（43）以标识密封组件的表面（42） 12）与其特定的试剂包。

公开(公告)号：WO1992022802A1

公开(公告)日：1992-12-23

申请号：PCT/US1992005103

申请日：1992-06-12

Applicant: ABBOTT LABORATORIES ,  CHOW, Herbert, S. ,  WILSON, Thomas, J. ,  ALSBERG, Keith, D. ,  McCOY, Jimmy, D. ,  SEBESTA, Esward, E.

Inventor： ABBOTT LABORATORIES

IPC: G01N21/03

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: A reaction cartridge (10) for an automatic analysis apparatus having a plurality of reaction wells (16) having different reagents disposed thereon, at least one sample well (11a, 11b), a well (12) containing magnetically separable particles for binding the sample, a fluorophore containing well (13), and a wash area (15) for washing a probe.

Abstract translation: 一种用于自动分析装置的反应盒（10），具有设置在其上的具有不同试剂的多个反应孔（16），至少一个样品阱（11a，11b），含有用于结合样品的可磁分离颗粒的孔（12） ，含有荧光团（13）的荧光团和用于洗涤探针的洗涤区域（15）。

公开(公告)号：WO1992022801A1

公开(公告)日：1992-12-23

申请号：PCT/US1992005028

申请日：1992-06-11

Applicant: ABBOTT LABORATORIES ,  CHOW, Herbert, S. ,  WILSON, Thomas, J. ,  WROBLEWSKI, Mieczyslaw ,  KOTLARIK, John, J. ,  ALSBERG, Keith, D. ,  McCOY, Jimmy, D. ,  LADD, Jimmy, L. ,  CORBETT, Kevin, M.

Inventor： ABBOTT LABORATORIES

IPC: G01N21/01

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: An apparatus is provided for moving a reaction cartridge (10) to different processing areas (36, 38, 42) of the apparatus. Robots (34, 40) for moving the reaction cartridge to the various areas (30, 32, 36, 38, 42, 46) of the apparatus. An image forming device (42) is provided to detect images which indicate whether specific reactions have occurred in reaction wells (16) of the reaction cartridge (10). The apparatus also includes a mechanism (36) for aspirating and dispensing liquids which includes a liquid level detecting mechanism (70, 72, 74, 76, 78, 80, 82, 84). The device further includes a microprocessor and logic (44) for controlling the apparatus operation and analyzing the information received from the image forming device (42) to generate a visual indication of assay results.

Abstract translation: 提供了一种用于将反应盒（10）移动到设备的不同处理区域（36,38,42）的装置。 用于将反应盒移动到设备的各个区域（30,32,36,38,42,46）的机器人（34,40）。 提供图像形成装置（42）以检测指示反应盒（10）的反应孔（16）中是否发生特定反应的图像。 该装置还包括用于吸入和分配液体的机构（36），该机构包括液面检测机构（70,72,74,76,78,80,82,84）。 该装置还包括微处理器和逻辑（44），用于控制装置操作并分析从图像形成装置（42）接收的信息以产生测定结果的视觉指示。

公开(公告)号：WO1992021770A1

公开(公告)日：1992-12-10

申请号：PCT/US1992002980

申请日：1992-04-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Janina ,  BERRY, Daniel, S. ,  FICO, Rosario ,  JOU, Yi-Her ,  STROUPE, Stephen, D.

IPC: C12Q01/00

CPC classification number: G01N33/538

Abstract: This invention presents novel assay methods employing a capture reagent, involving a first binding member typically conjugated to a polymeric anion substance, and a solid phase material containing a reaction site comprising a polymeric cation substance having a nitrogen content of at least about two percent. In one embodiment a test sample suspected of containing the analyte of interest may be contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex. The use of a polycationic substance, having a nitrogen content of at least about two percent (excluding the counter ions), to prepare a suitably charged solid phase provides a solid phase that can be subjected to a greater extent of manipulation, such as multiple washes, without losing the capability to attract and retain the capture reagent.

Abstract translation: 本发明提出了使用捕获试剂的新型测定方法，其包括通常与聚合物阴离子物质结合的第一结合构件，以及含有含有至少约2％氮含量的聚合阳离子物质的反应位点的固相材料。 在一个实施方案中，怀疑含有感兴趣的分析物的测试样品可与捕获试剂接触以形成带电的捕获试剂/分析物复合物。 然后将络合物与相反电荷的固相接触以吸引，附着和固定捕获试剂/分析物复合物。 使用具有至少约2％的氮含量（不包括抗衡离子）的聚阳离子物质来制备适当带电的固相，提供可以进行更大程度操作的固相，例如多次洗涤 ，而不失去吸引和保留捕获试剂的能力。

公开(公告)号：WO1992021769A1

公开(公告)日：1992-12-10

申请号：PCT/US1992002979

申请日：1992-04-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Janina ,  BERRY, Daniel, S. ,  FICO, Rosario ,  JOU, Yi-Her ,  STROUPE, Stephen, D.

IPC: C12Q01/00

CPC classification number: G01N33/54393 ,  G01N33/538 ,  G01N33/54353 ,  G01N33/544

Abstract: The present invention includes novel assays and reagents using a capture reagent, involving a specific binding member attached to a polymeric anionic substance, and a solid phase material containing a capture or reaction zone including a polymeric cationic substance. A test sample suspected of containing the analyte of interest may be contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex. With an appropriate indicator reagent, sandwich, competitive and indirect assays can be performed. Preferably, the indicator reagent includes a nonspecific binding blocker to reduce the nonspecific binding between the indicator reagent and the solid phase, without interfering with the reaction between the capture reagent and the solid phase. Suitable nonspecific binding blockers include unbound or free polyanionic materials such as dextran sulfate, heparin, carboxymethyl dextran, carboxymethyl cellulose, pentosan polysulfate, inositol hexasulfate or beta -cyclodextrin sulfate.

Abstract translation: 本发明包括使用捕获试剂，包括连接到聚合阴离子物质的特异性结合成员的新型测定和试剂，以及含有包含聚合阳离子物质的捕获或反应区的固相材料。 怀疑含有感兴趣的分析物的测试样品可以与捕获试剂接触以形成带电的捕获试剂/分析物复合物。 然后将络合物与相反电荷的固相接触以吸引，附着和固定捕获试剂/分析物复合物。 使用适当的指示剂，夹心，可以进行竞争性和间接测定。 优选地，指示剂试剂包括非特异性结合阻断剂，以减少指示剂与固相之间的非特异性结合，而不干扰捕获试剂和固相之间的反应。 合适的非特异性结合阻断剂包括未结合或游离的聚阴离子材料，例如硫酸葡聚糖，肝素，羧甲基葡聚糖，羧甲基纤维素，戊聚糖多硫酸酯，六水合硫酸肌醇或硫酸β-环糊精。