公开(公告)号：WO1996036274A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006805

申请日：1996-05-14

Applicant: ICN PHARMACEUTICALS

Inventor： ICN PHARMACEUTICALS ,  ZEYTINOGLU, Fusun ,  THIEBAUT, Franz, B.

IPC: A61B05/00

CPC classification number: G01N33/569 ,  A61B10/0035 ,  G01N33/53 ,  G01N33/54366 ,  G01N2333/025 ,  G01N2333/035 ,  G01N2333/15 ,  G01N2333/16 ,  G01N2333/20 ,  G01N2333/33 ,  G01N2333/35 ,  G01N2333/38 ,  G01N2333/40 ,  Y02A50/54 ,  Y10S436/805

Abstract: An antibody targeted to an antigen is brought into contact with a body component in situ. The resulting antibody/antigen complex is labeled and may be amplified. The label is then detected either in situ or ex situ.

Abstract translation: 使靶向抗原的抗体与原位成分接触。 所得的抗体/抗原复合物被标记并可以扩增。 然后在原位或非原位检测标记。

公开(公告)号：WO1996034558A1

公开(公告)日：1996-11-07

申请号：PCT/US1996006031

申请日：1996-05-01

Applicant: HEART RHYTHM TECHNOLOGIES, INC.

Inventor： HEART RHYTHM TECHNOLOGIES, INC. ,  SHERMAN, Marshall, L. ,  CASTELLANO, Thomas, M. ,  MOYA, Jose, J.

IPC: A61B05/00

CPC classification number: A61B5/01

Abstract: This invention is a system for monitoring temperature comprising a first thermocouple temperature sensor (24) mounted to a catheter (10), the catheter (10) also having a connector with a plurality of connecting devices (38) for making the thermocouple signals available to external equipment. The connecting devices (38) are formed of a material dissimilar to at least one of the thermocouple leads such that a second thermocouple is created at the connection point. The second thermocouple produces a second temperature signal combines with the signal from the first thermocouple. A reference temperature sensor (44) is mounted to the connector (38) to sense the temperature at the connector and provide a reference temperature signal for use by a processor (66) in correcting the combined temperature signal to derive the first thermocouple signal received from the connector.

Abstract translation: 本发明是一种用于监测温度的系统，包括安装在导管（10）上的第一热电偶温度传感器（24），该导管（10）还具有连接器，多个连接装置（38）用于使热电偶信号可用于 外部设备。 连接装置（38）由不同于至少一个热电偶引线的材料形成，使得在连接点处形成第二热电偶。 第二个热电偶产生与第一个热电偶信号相结合的第二个温度信号。 参考温度传感器（44）安装到连接器（38）以感测连接器处的温度，并提供参考温度信号，供处理器（66）用于校正组合温度信号以导出从第一热电偶信号 连接器。

公开(公告)号：WO1996031154A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004161

申请日：1996-03-29

Applicant: SAK, Robert, F.

Inventor： SAK, Robert, F.

IPC: A61B05/00

CPC classification number: A61B5/150488 ,  A61B5/15003 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150572 ,  A61B5/150656 ,  A61B5/150916 ,  A61B5/154 ,  A61M2005/3206 ,  A61M2005/3228

Abstract: This invention is a phlebotomy system (10) including a needle assembly (12), a retraction assembly (16), and a cylindrical barrel (14). The needle assembly (12) includes a needle cannula (30) with a first and second ends, a needle sleeve (24) for supporting the needle cannula (30) and having a flared proximal end, and a hub (18) into which the needle sleeve (24) is inserted. The cylindrical barrel (14) is threadedly secured to the hub (18). The retraction assembly (16) includes a central plate (48) with a central opening through which the needle sleeve (24) extends. When a downward force is applied to the retraction assembly (16), the retraction assembly (16) is moved to an active position such that a locking port (64) is axially aligned with and thereby engages the needle sleeve. Hence, the locking port engages the flared proximal end of the needle sleeve (24) when the retraction (16) assembly is moved rearward and the needle cannula (30) is retracted into the barrel (14). In an alternative embodiment, the needle sleeve is threadedly engaged with the central opening of the retraction assembly and likewise results in retraction of the needle cannula into the barrel.

Abstract translation: 本发明是一种静脉切开术系统（10），包括针组件（12），缩回组件（16）和圆柱形管（14）。 针组件（12）包括具有第一和第二端的针管（30），用于支撑针管（30）并具有扩张近端的针套（24）和毂（18），其中 针套（24）插入。 圆筒体（14）螺纹地固定到轮毂（18）上。 缩回组件（16）包括具有中心开口的中心板（48），针套24延伸穿过该中心开口。 当将向下的力施加到缩回组件（16）时，缩回组件（16）被移动到活动位置，使得锁定口（64）与针套轴向对齐并由此与针套接合。 因此，当缩回（16）组件向后移动并且针插管（30）缩回到筒体（14）中时，锁定口接合针套筒（24）的扩张近端。 在替代实施例中，针套与收缩组件的中心开口螺纹接合，并且同样导致针插管回缩到筒中。

公开(公告)号：WO1996029927A2

公开(公告)日：1996-10-03

申请号：PCT/US1996004317

申请日：1996-03-28

Applicant: SENSOR DEVICES, INC.

Inventor： SENSOR DEVICES, INC. ,  YOUNG, Robert, L. ,  GORSKI, Stephen, H. ,  MAINIERO, Louis, M.

IPC: A61B05/00

CPC classification number: A61B5/6855 ,  A61B5/0421 ,  A61B5/1459 ,  A61B5/42 ,  A61B5/4519 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6859 ,  A61B5/6885 ,  A61B7/023 ,  A61M2205/3368

Abstract: A probe (110) useful for invasively monitoring the oxygen saturation level of blood in the tissue walls of an anatomical cavity, for example in the esophagus, rectum or vaginal cavity of a human patient. The probe (110) may also be suitably employed in many veterinary applications. The probe (110) generally comprises a chassis (112) with an electrical connector extending from the proximal end of the chassis and terminating at a plug (132) configured for connection to a pulse oximeter box. The probe (110) further includes an optics assembly (126, 128) configured for either reflective or transmissive optics and configured to generate and transmit electrical signals that are indicative of the dynamic oxygen saturation level of blood in the wall tissue. In a further embodiment of the invention, the probe (110) may include a deployment device (119) attached to the chassis (112), for biasing the optics assembly (126, 128) into the tissue wall of the anatomical canal. The deployment device (118) may be, for example, a spring, a balloon or any other biasing device which urges the optics assembly into the wall tissue of the anatomical cavity. Further, the oximetry sensing assembly may be configured as part of an esophageal stethoscope having other sensing devices, for example, a temperature sensor (122), a pacing assembly (135), and an acoustic monitor (124).

Abstract translation: 探针（110），其可用于侵入性地监测解剖腔的组织壁中的血液的氧饱和度水平，例如在患者的食管，直肠或阴道腔中。 探针（110）也可适用于许多兽医应用。 探针（110）通常包括具有电连接器的底架（112），该电连接器从底架的近端延伸并终止于被配置用于连接到脉搏血氧仪盒的插头（132）。 探针（110）还包括被配置用于反射或透射光学器件的光学组件（126,128），并被配置为产生和传输指示壁组织中血液的动态氧饱和度水平的电信号。 在本发明的另一实施例中，探针（110）可以包括附接到底架（112）的展开装置（119），用于将光学组件（126,128）偏压到解剖管的组织壁中。 展开装置（118）可以是例如弹簧，球囊或任何其它偏压装置，其将光学组件推动到解剖腔的壁组织中。 此外，血氧定量检测组件可以被配置为具有其它感测装置的食管听诊器的一部分，例如温度传感器（122），起搏组件（135）和声学监测器（124）。

公开(公告)号：WO1996029002A1

公开(公告)日：1996-09-26

申请号：PCT/US1996003607

申请日：1996-03-14

Applicant: UNIVERSITY OF SOUTH FLORIDA ,  BERCU, Barry, B. ,  WALKER, Richard, F.

Inventor： UNIVERSITY OF SOUTH FLORIDA

IPC: A61B05/00

CPC classification number: C07K14/60 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/61

Abstract: A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The inventive protocol includes measuring GH secretion, as determined by changes in serum, plasma, or whole blood GH concentrations following administration of the xenobiotic GH releasing hexapeptide (GHRP-6) or any of its peptidyl or non-peptidyl synthetic analogues that release GH by the same cellular mechanism as GHRP-6. The naturally occurring GH releasing compound (GHRC) or its analogues is also administered to children and adults afflicted with disorders related to GH deficiency and GH secretion is measured. After evaluating the effects of independent administration of the GH secretagogues upon changes in blood GH concentrations, the effect of the co-administered GH secretagogues on blood GH concentrations in the child or adult subject is then measured.

Abstract translation: 公开了用于评估垂体生长激素（GH）分泌能力作为识别儿童和成人GH缺乏病因的手段的诊断方案和试剂盒。 本发明方案包括测量GH分泌，其通过施用异生物GH释放六肽（GHRP-6）或其任何其释放GH的肽基或非肽基合成类似物之后的血清，血浆或全血GH浓度的变化来确定， 与GHRP-6相同的细胞机制。 天然存在的GH释放化合物（GHRC）或其类似物也被施用于患有与GH缺乏和GH分泌相关的疾病的儿童和成人。 在评估GH分泌剂独立施用对血液GH浓度变化的影响后，测定共同施用的GH促分泌素对儿童或成人受试者血液GH浓度的影响。

公开(公告)号：WO1996029000A1

公开(公告)日：1996-09-26

申请号：PCT/IB1996000201

申请日：1996-03-11

Applicant: PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB

Inventor： PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB ,  PAPAIOANNOU, Dimitrios

IPC: A61B05/00

CPC classification number: A61B5/0091 ,  A61B5/4312

Abstract: A device for localizing an object (118) in a turbid medium (111), comprising a laser (100) which is used for generating amplitude-modulated light which is conducted into a turbid media (111), and a detection unit (107) for measuring the amplitude-modulated light emanating from the turbid media. A signal processing unit (109) measures a phase and amplitude from the detector signal (115). It appears that the accuracy of the measured phase is influenced by higher harmonics present in the detector signal (115). The accuracy of the phase detection is improved by reducing the higher harmonics in the detector signal (115). This is achieved by reducing the higher harmonics in the amplitude-modulated light from the laser (100) by utilizing a two-mode laser.

Abstract translation: 一种用于将物体（118）定位在混浊介质（111）中的装置，包括用于产生传导到浑浊介质（111）中的调幅光的激光（100）和检测单元（107） 用于测量从混浊介质发出的幅度调制光。 信号处理单元（109）从检测器信号（115）测量相位和幅度。 看来，测量相位的精度受检测器信号（115）中存在的高次谐波的影响。 通过降低检测器信号（115）中的高次谐波来提高相位检测的精度。 这是通过利用双模激光器来降低来自激光器（100）的调幅光的高次谐波来实现的。

公开(公告)号：WO1996028085A1

公开(公告)日：1996-09-19

申请号：PCT/US1996003536

申请日：1996-03-14

Applicant: NELLCOR PURITAN BENNETT INCORPORATED

Inventor： NELLCOR PURITAN BENNETT INCORPORATED ,  MANNHEIMER, Paul, D.

IPC: A61B05/00

CPC classification number: A61B5/14551 ,  A61B5/14552 ,  A61B2562/0242 ,  G01N21/314 ,  G01N21/49

Abstract: An apparatus of and method for measuring arterial blood oxygen saturation at a particular tissue level of interest. Visible and near infrared radiation is emitted into a patient at the measurement site using two different wavelengths. Detection at two different detection sites permits rejection of oxygen saturation at undesired tissue levels.

Abstract translation: 用于测量感兴趣的特定组织水平的动脉血氧饱和度的装置和方法。 使用两种不同的波长将可见和近红外辐射发射到测量位置的患者。 在两个不同检测位点的检测允许排除不希望的组织水平的氧饱和度。

公开(公告)号：WO1996026669A1

公开(公告)日：1996-09-06

申请号：PCT/US1995017004

申请日：1995-12-27

Applicant: SCIMED LIFE SYSTEMS, INC.

Inventor： SCIMED LIFE SYSTEMS, INC. ,  SCOVIL, Brian, J. ,  BERG, Todd, A. ,  BACHINSKI, Thomas, J. ,  THOME, Scott ,  KLITZ, Kevin ,  HUMPHREY, John, W. ,  HASTINGS, Roger

IPC: A61B05/00

CPC classification number: A61M25/0169 ,  A61M25/0127 ,  A61M25/09041 ,  A61M2025/09116

Abstract: A guide catheter exchange device and method of exchanging a guide catheter are disclosed. The guide catheter exchange device includes a magnetically responsive segment (34) located on a proximal end for maintaining a previously placed guide wire (36) in position across a stenosis (30) while performing a guide catheter exchange procedure.

Abstract translation: 公开了一种引导导管交换装置和更换导向导管的方法。 引导导管交换装置包括位于近端的磁响应段（34），用于在执行引导导管交换过程时将先前放置的导丝（36）保持在狭窄（30）的适当位置。

公开(公告)号：WO1996026668A1

公开(公告)日：1996-09-06

申请号：PCT/DE1996000356

申请日：1996-02-27

Applicant: KNOLL, Meinhard

IPC: A61B05/00

CPC classification number: A61B5/6865 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/686

Abstract: The invention concerns an implantable sensor system for determining concentrations of substances in living organisms, and a method for producing the same. Said system is characterized in that the substance-recognizing surface (1, 1') of at least one sensor (2, 2') is connected to at least one microtube-like permeable and flexible capillary membrane (3, 3') which, after implantation, contacts the living organism well. The capillary membrane is filled with a substance (4) enabling the substance to be analyzed, which has passed from the exterior into the interior of the capillary membrane (3, 3'), to be transported to the substance-recognizing sensor surface (1, 1'). The capillary membrane is connected by means of a duct (11, 11') in a holder (5, 5') to at least one septum (6, 6') such that substances can be introduced into and removed from the interior of the capillary membrane through the septum by means of an injection needle. Sensors of this type can be used for continuously measuring concentrations of glucose, lactate and other substances to be analyzed in the tissue or blood vessels of humans, animals and other organisms.

Abstract translation: 一种可植入的传感器系统，用于确定在活的有机体和方法及其制备的材料浓度。 本发明涉及一种可植入的传感器系统，用于确定在活的有机体的物质的浓度，其特征在于具有至少一个微孔管状可渗透的和灵活的毛细管膜的材料，识别面（1，1“）的至少一个传感器（2，2”）（3，3“） 被连接，其进入与注入后的活生物体的良好接触，在另外的毛细管填充有物质（4）中，材料识别外部的输送到毛细管膜的内部（3，3“）输入的分析物 传感器表面（1,1“）还允许毛细管通过的通道（11，11的装置”）在保持器（5,5“）的至少一个隔片（6,6”）连接，与的帮助下 可以通过添加到毛细管膜和除去的内部隔膜材料是注射针。 这样的传感器可以用于连续测量在人，动物和其他生物的组织或血管葡萄糖，乳酸和其它分析物的浓度。

公开(公告)号：WO1996021393A1

公开(公告)日：1996-07-18

申请号：PCT/US1996000321

申请日：1996-01-11

Applicant: MIGADA, INC. ,  SHEMESH, Eli ,  LEVINHAR, Zvi ,  ROGEL, Eitan

Inventor： MIGADA, INC.

IPC: A61B05/00

CPC classification number: G01N35/1079 ,  A61B5/15003 ,  A61B5/150389 ,  A61B5/150488 ,  A61B5/150496 ,  A61B5/150572 ,  A61B5/150717 ,  A61B5/150732 ,  A61B5/150992 ,  A61B5/155 ,  B01L3/0296

Abstract: This invention is a blood sampling apparatus operative to selectively and removably interconnect a blood sample container (12) with an extracorporeal blood conduit (14), and including a blood interface assembly adapted to securely and removably puncture both said blood conduit and said blood sample container (12); the blood interface assembly comprising an elongate housing, a needle mount (40) removably mounted in said elongated housing (30), a double pointed needle (48) fixedly adhesively mounted in said needle mount (40) in opposite directions, and a puncturable resilient sheath (58) formed over at least one portion of said needle and onto at least a portion of said needle mount.

Abstract translation: 本发明是一种血液取样装置，其可操作以选择性地和可拆卸地将血液样本容器（12）与体外血液导管（14）相互连接，并且包括血液界面组件，其适于牢固地和可移除地刺穿所述血液导管和所述血液样本容器 （12）; 所述血液界面组件包括细长壳体，可移除地安装在所述细长壳体（30）中的针座（40），以相反方向固定地粘合地安装在所述针座（40）中的双尖针（48） 护套（58）形成在所述针的至少一部分上并且到达所述针座的至少一部分上。