公开(公告)号：WO2017136689A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016453

申请日：2017-02-03

Applicant: ACADEMIA SINICA ,  NATIONAL TAIWAN UNIVERSITY ,  WONG, Chi-Huey

Inventor： WONG, Chi-Huey ,  YANG, Pan-Chyr ,  FANG, Jim-Min ,  PAN, Szu-Hua ,  CHENG, Ting-Jen, R. ,  LI, Ling-Wei

IPC: C07D473/00 ,  A61K31/52 ,  A61K31/506 ,  A61K31/337 ,  A61K45/06

CPC classification number: A61K31/337 ,  A61K31/506 ,  A61K31/52 ,  A61K45/06 ,  C07D473/00

Abstract: The present disclosure provides compounds of Formulas (I') and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.

Abstract translation: 本公开提供了式（I'）和（I）的化合物及其药学上可接受的盐。 本文所述的化合物可用于治疗和/或预防增殖性疾病（例如癌症）。 本发明还提供了用于治疗增殖性疾病的药物组合物，试剂盒及其用途。

公开(公告)号：WO2016137992A2

公开(公告)日：2016-09-01

申请号：PCT/US2016/019128

申请日：2016-02-23

Applicant: YANG, An-Suei ,  ACADEMIA SINICA

Inventor： YANG, An-Suei ,  CHEN, Hong-Sen ,  CHEN, Ing-Chien ,  TUNG, Chao-Ping ,  HOU, Shin-Chen ,  YU, Chung-Ming ,  YANG, Chi-Kai ,  CHIU, Yi-Kai

IPC: A61K48/00 ,  C40B30/04

CPC classification number: C07K16/005 ,  C07K16/1018 ,  C07K16/18 ,  C07K16/22 ,  C07K16/245 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N15/1037

Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1 ) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

Abstract translation: 本文公开了噬菌体展示的单链可变片段（scFv）文库，其包含多个噬菌体展示的scFv，其特征在于（1）特定的CS组合; （2）每个CDR中芳香族残基的特定分布; 和（3）每个CDR中的特定序列。 本发明的scFv文库可用于有效产生对不同抗原具有结合亲和力的不同抗体。 因此，本公开提供了根据实验研究和/或临床应用中的需要，迅速产生不同抗原特异性抗体的潜在手段。

公开(公告)号：WO2016123593A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015858

申请日：2016-01-30

Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey

Inventor： WONG, Chi-Huey ,  WU, Chung-Yi ,  MA, Che ,  WU, Han-Chung

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/24 ,  C07K16/10 ,  A61K39/42

CPC classification number: C07K16/32 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2887 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

Abstract translation: 本公开涉及包含抗体或其结合片段的组合物和使用方法，其还包含通用Fc糖形式。

公开(公告)号：WO2016118191A1

公开(公告)日：2016-07-28

申请号：PCT/US2015/046420

申请日：2015-08-21

Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey

Inventor： WU, Chung-Yi

IPC: G01N33/53

CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/627 ,  C07H15/04 ,  C07H15/26 ,  C07K16/3076 ,  C07K16/44

Abstract: The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract translation: 本公开涉及针对SSEA3 / SSEA4 / GloboH相关表位（天然和修饰）的疫苗，抗体和/或免疫原性缀合物组合物，其引发可用于调节globo系列鞘糖脂合成的抗体和/或结合片段生产。 本公开涉及可以调节globo系列鞘糖脂合成的方法和组合物。 特别地，本公开涉及可以调节生物合成途径中的globo系列鞘糖脂SSEA3 / SSEA4 / GloboH的合成的糖酵母抑制剂化合物及其组合物和使用方法; 特别是糖酵解抑制剂靶向α-4GalT; 的β-4GalNAcT-I; 或β-3GalT-V酶在globo系列合成途径中。 此外，本公开还涉及使用本文所述的组合物治疗或检测过度增殖性疾病和/或病症的方法。

公开(公告)号：WO2016094587A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/064841

申请日：2015-12-09

Applicant: ACADEMIA SINICA ,  YANG, Ning-Sun

Inventor： YANG, Ning-Sun ,  WEI, Wen-Chi ,  LIN, Sheng-Yen ,  HSIAO, Pei-Wen ,  CHEN, Yet-Ran

IPC: A61K36/28

CPC classification number: A61K36/28 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2236/00 ,  C07K16/2803 ,  C07K2317/92

Abstract: A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulocytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount of Bidens pilosa extract, or more than one polyacetylenic compounds purified or isolated from the B. pilosa extract, and a pharmaceutically acceptable carrier.

Abstract translation: 公开了用于抑制有需要的受试者的粒细胞骨髓来源的抑制细胞（gMDSC）的分化，功能活性和群体和/或抑制肿瘤转移的药理学组合物。 所述组合物包含治疗有效量的Bidens pilosa提取物或多于一种从B.pilosa提取物纯化或分离的聚乙炔化合物和药学上可接受的载体。

公开(公告)号：WO2016036727A1

公开(公告)日：2016-03-10

申请号：PCT/US2015/047917

申请日：2015-09-01

Applicant: ACADEMIA SINICA

Inventor： SHEN, Che-Kun James ,  SHYU, Yu-Chiau

IPC: A01N63/00 ,  C12N5/00 ,  C12N15/00

CPC classification number: C07K14/4702 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/1709 ,  A61K45/06 ,  C07K14/4703 ,  Y02A50/402

Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis

Abstract translation: 本发明包括一种遗传修饰的非人类动物模型，其寿命延长，健康范围增加，其与减少的肿瘤发生和肿瘤转移相关，以及相关的增加寿命和健康跨度，减少肿瘤发生和肿瘤转移的方法，以及鉴定 增加寿命或健康范围，或减少肿瘤发生或肿瘤转移的活性剂

公开(公告)号：WO2016029071A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/046197

申请日：2015-08-21

Applicant: ACADEMIA SINICA ,  WONG, Chi-Huey

Inventor： WONG, Chi-Huey ,  WU, Chung-Yi ,  LEE, Hsin-Yu

IPC: C07K14/33 ,  C07K14/34

CPC classification number: C08B37/0024 ,  A61K39/0011 ,  A61K39/0016 ,  A61K47/36 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/555 ,  A61K2039/6037 ,  C07H3/06 ,  C07K14/33 ,  C07K14/34 ,  G01N2333/4728

Abstract: This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.

Abstract translation: 本公开内容包括含有（a）包含载体和一个或多个聚糖的聚糖缀合物的免疫原性组合物，其中所述一种或多种聚糖中的每一个通过接头与载体缀合，和任选地（b）佐剂。 一个或多个聚糖各自为Globo H衍生物。

公开(公告)号：WO2016022648A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/043761

申请日：2015-08-05

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE ,  ACADEMIA SINICA ,  LIU, Fu-Tong

Inventor： LIU, Fu-Tong ,  LIN, Yen-Ju ,  HUANG, Jui-Wen ,  CHEN, Huan-Yuan ,  HSIEH, Wei-Chen

IPC: C12Q1/68

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

Abstract: The present disclosure provides a small interfering RNA, including: (a) a first small interfering RNA consisting of a first passenger strand and a first guide strand; (b) a second small interfering RNA consisting of a second passenger strand and a second guide strand; (c) a third small interfering RNA consisting of a third passenger strand and a third guide strand; or (d) a fourth small interfering RNA consisting of a fourth passenger strand and a fourth guide strand.

Abstract translation: 本公开提供了小干扰RNA，其包括：（a）由第一乘客链和第一引导链组成的第一小干扰RNA; （b）由第二乘客股和第二引导线组成的第二小干扰RNA; （c）由第三乘客链和第三导丝组成的第三小干扰RNA; 或（d）由第四乘客链和第四引导链组成的第四小干扰RNA。

公开(公告)号：WO2016019255A1

公开(公告)日：2016-02-04

申请号：PCT/US2015/043133

申请日：2015-07-31

Applicant: ACADEMIA SINICA ,  NATIONAL TAIWAN UNIVERSITY ,  TAIPEI MEDICAL UNIVERSITY ,  LIANG, Chi-Ming

Inventor： PECK, Konan ,  YANG, Pan-Chyr ,  CHANG, Yi-chung ,  HUANG, Bo-Tsang ,  YEH, Shauh-Der

IPC: C12N15/115 ,  A61K31/711 ,  A61P35/00 ,  A61P37/00

CPC classification number: C12N15/115 ,  A61K9/0019 ,  A61K31/711 ,  A61K31/713 ,  A61K47/60 ,  C12N15/1138 ,  C12N2310/16 ,  C12N2310/351

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

Abstract translation: 提供了结合并抑制CTLA-4的适配体及其在增强免疫活性中的用途以及治疗癌症和HIV感染。

公开(公告)号：WO2016014761A1

公开(公告)日：2016-01-28

申请号：PCT/US2015/041687

申请日：2015-07-23

Applicant: CHEN, Yuan-Tsong ,  ACADEMIA SINICA

Inventor： CHEN, Yuan-Tsong ,  WU, Jer-Yuarn ,  KO, Tai-Ming ,  KUO, Ho-Chang ,  CHANG, Jeng-Sheng

IPC: G01N33/53 ,  A61K39/395 ,  A61P9/00 ,  A61P29/00

CPC classification number: G01N33/6893 ,  A61K31/56 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/00 ,  G01N33/6863 ,  G01N33/6869 ,  G01N2333/522 ,  G01N2333/54 ,  G01N2333/5418 ,  G01N2333/7056 ,  G01N2333/70578 ,  G01N2800/328

Abstract: Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off level. Also described is a kit for carrying out the method.

Abstract translation: 描述了在受试者中诊断，治疗或监测川崎病治疗的方法。 该方法包括检测从受试者获得的样品中的生物标志物的水平，生物标志物是IL-7F，sCD40L，MPIF-1，E-选择蛋白，IP-10或IL-33。 该水平与截止水平进行比较。 还描述了用于实施该方法的套件。