公开(公告)号：WO2015031685A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/053279

申请日：2014-08-28

Applicant: STC.UNM

Inventor： PLUSQUELLIC, James

IPC: G06F11/10

CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

Abstract translation: 本公开描述了用于分析由物理不可克隆功能（PUF）产生的位串的统计质量的技术。 PUF利用集成电路的电网线的电阻变化。 分析了串串的温度和电压稳定性。 本公开还描述了将电压降转换成数字代码，其中转换对于简单和差异的侧向信道攻击具有弹性。

公开(公告)号：WO2014200705A1

公开(公告)日：2014-12-18

申请号：PCT/US2014/039979

申请日：2014-05-29

Applicant: STC.UNM ,  DERETIC, Vojo, P. ,  MANDELL, Michale

Inventor： DERETIC, Vojo, P. ,  MANDELL, Michale

IPC: C12N9/00

CPC classification number: A61K31/201 ,  A61K38/53 ,  A61K45/06 ,  C12N9/93 ,  C12Q1/44 ,  C12Q1/61 ,  C12Y603/02 ,  G01N2333/92 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2500/20 ,  G01N2800/7028

Abstract: The present invention relates to the use of neutral lipids, including triglycerides, diglycerides and monoglycerides which may be used to increase neutral lipids (lipid stores and/or lipid droplets) and neutral lipid stores in order to regulate (in particular, induce) autophagy and treat and/or prevent autophagy related disease states and/or conditions. In one embodiment, the invention relates to the use of neutral lipids and/or TRIM proteins which may be used to regulate (in particular, induce) autophagy, target autophagic substrates and treat and/or prevent autophagic disease states and/or conditions.

Abstract translation: 本发明涉及使用中性脂质，包括甘油三酸酯，甘油二酯和甘油单酯，其可用于增加中性脂质（脂质储存和/或脂滴）和中性脂质储存物，以调节（特别是诱导）自噬和 治疗和/或预防自噬相关疾病状态和/或病症。 在一个实施方案中，本发明涉及可用于调节（特别是诱导）自噬，靶自噬底物并治疗和/或预防自噬性疾病状态和/或病症的中性脂质和/或TRIM蛋白的用途。

公开(公告)号：WO2014165617A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/032711

申请日：2014-04-02

Applicant: STC.UNM ,  SANDIA CORPORATION ,  CARNES, Eric C. ,  BRINKER, C. Jeffrey ,  ASHLEY, Carlee Erin

Inventor： CARNES, Eric C. ,  BRINKER, C. Jeffrey ,  ASHLEY, Carlee Erin

IPC: A61K9/16 ,  A61K47/48 ,  A61K38/20 ,  A61K49/04

CPC classification number: A61K39/39 ,  A61K9/127 ,  A61K9/146 ,  A61K9/5115 ,  A61K9/5184 ,  A61K31/365 ,  A61K38/19 ,  A61K39/0208 ,  A61K39/07 ,  A61K39/08 ,  A61K45/06 ,  A61K47/6923 ,  A61K47/6929 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2300/00

Abstract: The present invention relates to mesoporous alum nanoparticles which can be used as a universal platform for antigen adsorption, presentation and delivery to provide immune compositions, including vaccines and to generate an immune response (preferably, both humoral and cell mediated immune response), preferably a heightened immune response to the presentation of one or more antigens to a patient or subject.

Abstract translation: 本发明涉及介孔矾纳米颗粒，其可以用作抗原吸附，呈递和递送的通用平台，以提供免疫组合物，包括疫苗并产生免疫应答（优选体液和细胞介导的免疫应答），优选为 增加对一种或多种抗原呈递给患者或受试者的免疫应答。

公开(公告)号：WO2014113525A1

公开(公告)日：2014-07-24

申请号：PCT/US2014/011774

申请日：2014-01-16

Applicant: STC.UNM ,  SEROV, Alexey ,  ATANASSOV, Plamen, B.

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B.

IPC: B01J23/745 ,  B01J37/08 ,  H01M4/90

CPC classification number: H01M4/9041 ,  B01J27/24 ,  B01J35/0033 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/06 ,  B01J37/086 ,  H01M4/9091

Abstract: A sacrificial support-based method, a mechanosynthesis-based method, and a combined sacrificial support/mechanosynthesis support based method that enables the production of supported or unsupported catalytic materials and/or the synthesis of catalytic materials from both soluble and insoluble transition metal and charge transfer salt materials.

Abstract translation: 基于牺牲支持的方法，基于机械合成的方法和基于组合的牺牲支持/机械合成支持的方法，其能够从可溶性和不溶性过渡金属和电荷中产生负载或未负载的催化材料和/或催化材料的合成 转移盐料。

公开(公告)号：WO2013191772A1

公开(公告)日：2013-12-27

申请号：PCT/US2013/032025

申请日：2013-03-15

Applicant: STC.UNM ,  GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

Inventor： GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

IPC: G01N15/14 ,  G01N21/27 ,  C12Q1/02

CPC classification number: G01N15/1404 ,  G01N15/1459 ,  G01N2015/142

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

Abstract translation: 一种负担得起的流式细胞仪系统，具有显着增加的分析速率，体积样品输送和可用的粒度，包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光 流并将光成像到阵列检测器上。

公开(公告)号：WO2013049504A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057821

申请日：2012-09-28

Applicant: STC.UNM ,  EDWARDS, Jeremy ,  ZARKESH-HA, Payman ,  BRUECK, Steven, R.J.

Inventor： EDWARDS, Jeremy ,  ZARKESH-HA, Payman ,  BRUECK, Steven, R.J.

IPC: C12Q1/68 ,  C12N15/10 ,  C12N15/11

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N27/414 ,  G01N27/4145 ,  Y10T436/143333 ,  C12Q2531/125 ,  C12Q2535/122

Abstract: This disclosure describes, in one aspect, a method for preparing DNA molecule for sequencing. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; annealing a first sequencing primer to the first loop oriented to sequence at least a portion of one strand of the fragment; and annealing a second sequencing primer to the second loop oriented to sequence at least a portion of the other strand of the fragment. In another aspect, this disclosure describes a method for sequencing a DNA molecule. Generally, the method includes fragmenting the DNA molecule into double-stranded fragments; amplifying at least a portion of the double-stranded fragments; circularizing the fragments so that the first end of the fragment comprises a first loop connecting the strands and the second end of the fragment comprises a second loop connecting the strands; and sequencing at least one of the DNA strands.

Abstract translation: 本公开一方面描述了用于测序的DNA分子的制备方法。 通常，该方法包括将DNA分子分成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 将第一测序引物退火至所述第一环以定向以序列所述片段的一条链的至少一部分; 以及将第二测序引物退火至所述第二环，其定向为序列所述片段的另一条链的至少一部分。 在另一方面，本公开描述了用于测序DNA分子的方法。 通常，该方法包括将DNA分子分成双链片段; 扩增至少一部分双链片段; 使片段环化，使得片段的第一端包含连接线束的第一环和片段的第二端包括连接线的第二环; 并测序至少一个DNA链。

公开(公告)号：WO2013020096A2

公开(公告)日：2013-02-07

申请号：PCT/US2012/049613

申请日：2012-08-03

Applicant: STC.UNM ,  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED ,  WHITTEN, David G. ,  SCHANZE, Kirk S. ,  JI, Eunkyung ,  DASCIER, Dimitri ,  PARTHASARATHY, Anand ,  CORBITT, Thomas S. ,  CICOTTE, Kirsten ,  DIRK, Elizabeth LeBleu ,  ZHU, Xuzhi

Inventor： WHITTEN, David G. ,  SCHANZE, Kirk S. ,  JI, Eunkyung ,  DASCIER, Dimitri ,  PARTHASARATHY, Anand ,  CORBITT, Thomas S. ,  CICOTTE, Kirsten ,  DIRK, Elizabeth LeBleu ,  ZHU, Xuzhi

IPC: A01N25/34 ,  A61L15/00 ,  A61L15/10 ,  A61L15/42 ,  A01N33/12 ,  A01N27/00

CPC classification number: A01N43/90 ,  A01N25/34 ,  A01N33/12 ,  A01N37/10 ,  A01N43/10 ,  A61L15/20 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/404 ,  D01H7/00 ,  A01N59/00 ,  A01N2300/00

Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

Abstract translation: 本发明提供了用于污染诸如细菌的微生物感染的表面和织物（例如无纺织物）的去污方法和材料。 具有共轭的低聚（芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物可用于在存在氧气和任选地照射的情况下净化受感染的表面。 掺入具有共轭的低聚（芳基/杂芳基乙炔基）结构并包含至少一个阳离子基团的生物灭杀低聚物的纤维，其中所述低聚物与形成纤维的聚合物物理缔合或共价键合，或两者都可以用于形成非 - 编织席子。 通过掺入杀生物低聚物的本发明方法制备的杀生物无纺垫可用于抑制伤口和外科敷料和个人卫生产品中的细菌生长。

公开(公告)号：WO2012154975A2

公开(公告)日：2012-11-15

申请号：PCT/US2012/037352

申请日：2012-05-10

Applicant: STC.UNM ,  CHIGAEV, Alexandre ,  SKLAR, Larry, A.

Inventor： CHIGAEV, Alexandre ,  SKLAR, Larry, A.

IPC: A61K31/4162 ,  A61K31/519 ,  A61K31/52 ,  A61K31/506 ,  A61K31/34 ,  A61P35/00

CPC classification number: A61K31/708 ,  A61K31/132 ,  A61K31/506 ,  A61K31/655 ,  A61K31/665 ,  A61K45/06 ,  G01N33/5008 ,  G01N33/57488 ,  G01N2500/10 ,  G01N2800/50

Abstract: The invention provides methods of treating nitric oxide/cGMP pathway-cell adhesion disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention relates to a method for down-regulating α 4 β 1 -integrin affinity and inhibiting and reversing adhesion formation in patients or subjects in need using a nitric oxide donor.

Abstract translation: 本发明提供了治疗一氧化氮/ cGMP途径 - 细胞粘附病症和相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明涉及一种用于下调a4β1整合素亲和力并抑制和逆转患者或需要使用一氧化氮供者的受试者的粘连形成的方法。

公开(公告)号：WO2011112756A3

公开(公告)日：2011-09-15

申请号：PCT/US2011/027797

申请日：2011-03-09

Applicant: STC.UNM ,  SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

Inventor： SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: B05B7/14 ,  B05B7/24 ,  B05B7/02 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：WO2011082381A2

公开(公告)日：2011-07-07

申请号：PCT/US2010/062638

申请日：2010-12-31

Applicant: STC.UNM ,  PEABODY, David, S. ,  CHACKERIAN, Bryce

Inventor： PEABODY, David, S. ,  CHACKERIAN, Bryce

IPC: C12N7/01 ,  C12N15/33 ,  C07K14/005 ,  A61K39/12

CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one- on average- to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

Abstract translation: 本发明涉及用于控制病毒样颗粒（VLP）上肽显示效价的系统和方法，特别是包括MS2 VLP。 在这种方法中，大量的野生型和低量的单链二聚体外壳蛋白可以由单一RNA产生。 通过提供允许从单个RNA产生大量野生型和少量单链二聚体包被蛋白的系统，允许在VLP上显示效价水平的轻松调整，从而控制了Valence的免疫原（疫苗）生产，特别是 MS2 VLPS在很宽的范围内，从平均不到一个 - 到每个粒子多达九十个。 这有助于免疫原和疫苗的生产，包括低价价的VLP。 公开了用于表达病毒样颗粒的核酸构建体，其包含通过插入异源肽而修饰的MS2的外壳多肽，其中异源肽显示在病毒样颗粒上并包裹MS2 mRNA。 还公开了核酸构建体，其可用于表达由插入异源肽修饰的PP7外壳多肽组成的病毒样颗粒，其中异源肽显示在病毒样颗粒上并包裹PP7 mRNA。 / p>