公开(公告)号：WO1998001744A1

公开(公告)日：1998-01-15

申请号：PCT/GB1997001826

申请日：1997-07-04

Applicant: CAMBRIDGE IMAGING LIMITED ,  RUSHBROOKE, John, Gordon ,  HOOPER, Claire, Elizabeth ,  NEALE, William, Wray

Inventor： CAMBRIDGE IMAGING LIMITED

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An imaging system for fluorescence assays includes a fibre optic coupling plate (20, 24, 26) for transmitting radiation emitted by a sample (18) towards a camera. This is combined with an interference filter (22) so as to enable highly sensitive transmission of radiation to the camera, according to wavelength. The interference filter may be combined with a fibre optic coupling plate in which sample sites or wells of an array are viewed by separate fibre optic bundles, each bundle transmitting emitted light from a one sample or well to a discrete region of the field of view of the camera.

Abstract translation: 用于荧光测定的成像系统包括用于将样品（18）发射的辐射传送到相机的光纤耦合板（20,24,26）。 这与干涉滤波器（22）组合，以便能够根据波长实现对照相机的高度敏感的辐射传输。 干涉滤波器可以与光纤耦合板组合，其中阵列的采样点或阱由分开的光纤束观察，每个束将发射的光从一个样本或阱传输到视场的离散区域 相机。

公开(公告)号：WO1991001488A1

公开(公告)日：1991-02-07

申请号：PCT/US1990004130

申请日：1990-07-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  KENNEDY, Max, J. ,  WANG, Daniel, I, C. ,  STEPHANOPOULOS, Gregory, N.

IPC: G01N21/49

CPC classification number: G01N21/51 ,  G01N21/8507 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: This invention pertains to a method and an apparatus for determining concentration of solid particles of interest in a sample in the presence of at least one other type of solid particle by measuring light scatter at a wavelength which is independent of solid particle concentration which is not of interest and related to solid particle concentration of interest. Preferably, solid particles of interest are cells grown in cell culture medium comprising a solid substrate.

公开(公告)号：WO2018002923A2

公开(公告)日：2018-01-04

申请号：PCT/IL2017/050715

申请日：2017-06-27

Applicant: WARSHAVSKI, Omri

Inventor： WARSHAVSKI, Omri

IPC: G01N21/27

CPC classification number: G01N21/31 ,  A61B5/0059 ,  G01J3/0218 ,  G01J3/46 ,  G01J3/501 ,  G01N21/251 ,  G01N21/474 ,  G01N21/6408 ,  G01N2021/4742 ,  G01N2021/479 ,  G01N2201/0627 ,  G01N2201/0826

Abstract: A color imaging system and method, the method comprising., for a plurality of predetermined wavelength bands of illumination, calculating weight coefficients representing the contribution of each of the wavelength bands to a specific color space, individually controlling illumination intervals of each of a plurality of illumination sources, wherein each of the illumination sources is configured to provide illumination via a waveguide in a different predetermined narrow band of wavelengths, controlling an image sensor to capture a set of monochromatic image frames synchronously with the illumination intervals, receiving a set of the captured monochromatic Image frames, and generating color image data by calculating a combination of the set of image frames, each weighted by the corresponding coefficient.

Abstract translation: 彩色成像系统和方法，所述方法包括：针对多个预定波长的照明，计算表示每个波长带对特定色彩空间的贡献的加权系数，单独地控制 其中每个照明源被配置为经由波导以不同的预定窄波段提供照明，控制图像传感器以捕获与照明同步的一组单色图像帧 接收一组捕获的单色图像帧，并且通过计算一组图像帧的组合来生成彩色图像数据，每个图像帧的组合由对应的系数加权。

公开(公告)号：WO2016053613A3

公开(公告)日：2016-05-26

申请号：PCT/US2015050143

申请日：2015-09-15

Applicant: PERKINELMER HEALTH SCI INC

Inventor： DICESARE JOSEPH L ,  JIN FENG ,  NEAL TIMOTHY P ,  AIKENS DAVID

IPC: G01N21/03 ,  G01J3/44 ,  G01N21/05 ,  G01N21/64

CPC classification number: G01J3/0202 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0389 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0642 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/262

Abstract: A flow cell (250) for a fluorescence spectrometer includes a flow channel (254) to receive a flow of a liquid sample, an excitation light entrance window to receive excitation light from a light source, and an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow cell. The excitation light entrance window and/or emission light exit window includes a waveguide including: a waveguide core (261, 262) formed of a core material; and a cladding medium (274) surrounding a portion of the waveguide core (261, 262), wherein the cladding medium (274) has a refractive index less than the refractive index of the core material. The waveguide defines a portion of the flow channel (254). At least one mirror (270, 272) integral with the flow cell body is positioned to reflect excitation light that has passed through the liquid sample in the flow channel (254) back into the liquid sample and/or to reflect emission light emitted from the liquid sample toward the emission light exit window. The excitation light entrance window is spaced a first distance from the flow channel and the emission light exit window is spaced a second distance from the flow channel, whereby the second distance is less than the first distance.

Abstract translation: 用于荧光光谱仪的流动池（250）包括用于接收液体样品流的流动通道（254），用于接收来自光源的激发光的激发光入口窗口和用于透射荧光发射的发射光出射窗口 来自流动池的流动通道中的液体样品的光。 激发光入射窗口和/或发射光出射窗口包括波导，包括：由芯材形成的波导芯（261,262）; 以及围绕所述波导芯（261,262）的一部分的包层介质（274），其中所述包层介质（274）的折射率小于所述芯材料的折射率。 波导限定了流动通道（254）的一部分。 与流动池主体成一体的至少一个反射镜（270,272）被定位成将已经通过流动通道（254）中的液体样品的激发光反射回液体样品和/或反射从 液体样品朝向发射光出射窗口。 激发光入口窗口与流动通道间隔开第一距离，并且发射光出射窗口与流动通道间隔开第二距离，由此第二距离小于第一距离。

公开(公告)号：WO2016022746A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/043914

申请日：2015-08-06

Applicant: SCHLUMBERGER CANADA LIMITED ,  SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER HOLDINGS LIMITED ,  SCHLUMBERGER TECHNOLOGY B.V. ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： EARLEY, Drummond

IPC: G01N21/31 ,  G01N21/03 ,  G01N21/05

CPC classification number: G01N21/85 ,  G01N21/253 ,  G01N21/31 ,  G01N21/534 ,  G01N2021/8416 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A technique facilitates analysis of constituents in leaching operations by utilizing light energy and fiber optic transmission of light during the leaching operations. The light is used in situ in combination with a flow cell to measure desired constituents, e.g. copper, in a fluid flow stream. Additionally, the data obtained via the flow cell may be provided to a data processing system which may be used to automatically provide information, e.g. constituent concentration, within the flow stream. In many applications, the in situ fiber-optic transmission system and flow cell may be used in combination with the data processing system to provide real time information on the flow stream.

Abstract translation: 一种技术通过在浸出操作期间利用光能和光纤传输光来促进浸出操作中成分的分析。 光与流动池组合使用以测量所需的组分，例如， 铜，在流体流中。 另外，经由流池获得的数据可以被提供给数据处理系统，该数据处理系统可用于自动提供信息，例如， 成分浓度在流动流内。 在许多应用中，原位光纤传输系统和流通池可以与数据处理系统结合使用，以提供关于流量的实时信息。

公开(公告)号：WO2016010494A1

公开(公告)日：2016-01-21

申请号：PCT/TR2014/000301

申请日：2014-07-17

Applicant: KUANTAG NANOTEKNOLOJILER GELIŞTIRME VE ÜRETIM A.Ş. ,  KOÇ ÜNIVERSITESI

Inventor： UREY, Hakan ,  AKGUN, Osman Vedat ,  HEVES, Emre ,  CIVITCI, Fehmi ,  CAN, Basarbatu

IPC: G01J3/44 ,  G01N21/64

CPC classification number: G01N21/643 ,  G01N21/645 ,  G01N21/8507 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0624 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: In the present invention, a fluorescent substance detection system (S) for detecting fluorescent substances in any environment is provided. Said detection system (S) comprises at least one illumination unit (1) which emits light to said environment in order to excite said substances; detection units (2), at least at a number equal to the number of types of fluorescent substances, for detecting emissions coming from said excited fluorescent substances and bandpass filters (3), each connected to detection units (2) one by one, wherein bandpass filters (3) have a center wavelength matched to the center emission wavelength of corresponding fluorescent substance.

Abstract translation: 在本发明中，提供了用于检测任何环境中的荧光物质的荧光物质检测系统（S）。 所述检测系统（S）包括至少一个照射单元（1），其向所述环境发射光以激发所述物质; 检测单元（2），至少等于荧光物质的数量的数量，用于检测来自所述激发的荧光物质的发射和带通滤光器（3），每个检测单元（2）逐个连接到检测单元（2），其中 带通滤波器（3）具有与相应荧光物质的中心发射波长匹配的中心波长。

公开(公告)号：WO2015075629A1

公开(公告)日：2015-05-28

申请号：PCT/IB2014/066129

申请日：2014-11-18

Applicant: VERSALIS S.P.A.

Inventor： BONACINI, Francesco ,  MANTOVANI, Erik ,  FERRANDO, Angelo

IPC: G01N21/85

CPC classification number: G01N21/272 ,  C08F112/08 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N2201/061 ,  G01N2201/0826 ,  G01N2201/13

Abstract: The present invention relates to a method for monitoring a control parameter of a polymerization reaction mixture in heterogeneous phase comprising the following steps: (a) acquiring at least one NIR reflectance spectrum of said mixture; (b) calculating a value of said control parameter by means of a calibration curve which correlates the NIR reflectance spectrum with the values of said control parameter measured with a reference measurement method. The present invention also relates to an apparatus for implementing said method.

Abstract translation: 本发明涉及用于监测异相聚合反应混合物的控制参数的方法，包括以下步骤：（a）获得所述混合物的至少一个NIR反射光谱; （b）通过校正曲线计算所述控制参数的值，所述校准曲线将NIR反射光谱与用参考测量方法测量的所述控制参数的值相关联。 本发明还涉及一种用于实现所述方法的装置。

公开(公告)号：WO2011124918A1

公开(公告)日：2011-10-13

申请号：PCT/GB2011/050686

申请日：2011-04-06

Applicant: IT-IS INTERNATIONAL LIMITED ,  WEBSTER, Benjamin, Masterman ,  HOWELL, James, Richard

Inventor： WEBSTER, Benjamin, Masterman ,  HOWELL, James, Richard

IPC: B01L7/00 ,  G01N21/64

CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A chemical and/or biochemical system (1) having at least one reaction vessel (3) in which chemical and/or biochemical reactions may take place, the temperature of the reaction vessels being cycled between at least a highest predetermined temperature and a lowest predetermined temperature, the system comprising a thermal mount (4) for receiving the reaction vessel (s), the thermal mount being thermally coupled to a first, thermally conductive side of a thermoelectric module (5), a second thermally conductive side of the thermoelectric module being thermally coupled to a heat sink (6) and being provided with a pair of electrical contacts (33) to which a pair of electrically conductive wires (34) is connected for coupling to a power source, characterized in that a flexible adhesive (31, 32) is provided between the first thermally conductive side of the thermoelectric module and the thermal mount and between the second thermally conductive side of the thermoelectric module and the heat sink, whereby the adhesive is relatively thermally insulating compared to the first and second thermally conductive sides of the thermoelectric module and forms the sole coupling, thermal or mechanical, between the thermoelectric module and the thermal mount and between the thermoelectric module and the heat sink.

Abstract translation: 化学和/或生化系统（1）具有至少一个其中可能发生化学和/或生物化学反应的反应容器（3），反应容器的温度在至少最高预定温度和最低预定温度之间循环 所述系统包括用于接收所述反应容器的热安装座（4），所述热安装件热耦合到热电模块（5）的第一导热侧，所述热电模块的第二导热侧 被热耦合到散热器（6）并且设置有一对电触点（33），一对导电线（34）连接到所述一对电触头（34）以耦合到电源，其特征在于，柔性粘合剂（31） ，32）设置在热电模块的第一导热侧和热座之间以及热电模块的第二导热侧之间，并且热sin k，由此与热电模块的第一和第二导热侧相比，粘合剂相对热绝缘，并且在热电模块和热安装座之间以及热电模块和散热器之间形成热耦合或机械的单独耦合。

公开(公告)号：WO2010079338A2

公开(公告)日：2010-07-15

申请号：PCT/GB2010/000028

申请日：2010-01-08

Applicant: IT-IS INTERNATIONAL LTD ,  HOWELL, James, Richard ,  WEBSTER, Benjamin, Masterman ,  CLARK, Mark, Quentin ,  HOWELL, Richard, Alfred

Inventor： HOWELL, James, Richard ,  WEBSTER, Benjamin, Masterman ,  CLARK, Mark, Quentin ,  HOWELL, Richard, Alfred

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.

Abstract translation: 公开了一种用于检测在多个反应容器（3）中发生的化学或生物化学反应产生的光中的光谱的装置。 每个反应容器（3）具有容纳部分，该容器部分具有能够发出光的发射区域。 该装置可以包括具有孔（6）阵列的掩模元件（5），来自每个反应容器（3）的光可以通过该孔排出。 多个光波导（7）布置成将来自掩模元件（5）中的孔（6）的光引导到用于将来自每个波导（7）的光分散到分散光谱中的光分散装置（8）。 光检测装置（10）基本上同时检测光的分散光谱中的特定光谱。 在一个实施例中，孔（6）的尺寸基本上小于反应容器的发射面积，但是在另一个实施例中，孔（6）的大小与反应容器的发射面积基本相似，并且光波导 （7）的直径从直径基本上相似于反应容器顶部的面积的第一端逐渐变细到直径基本上较小的第二端。 在替代实施例中，当来自小孔的光直接指向光分散装置时，不使用光波导。 在另一替代实施例中，为每个反应容器提供几个光波导，每个波导将光引导到不同的检测器以检测不同的特定光谱。

公开(公告)号：WO2010016795A1

公开(公告)日：2010-02-11

申请号：PCT/SE2009/050918

申请日：2009-08-04

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB ,  BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

Inventor： BARASH, Eugene ,  FINEHOUT, Erin ,  PIETRZYKOWSKI, Matthew, Damian ,  XIA, Hua ,  ZHU, Li

IPC: G01N27/447 ,  G01N21/64 ,  G01N33/487

CPC classification number: G01N21/645 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/08 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.

Abstract translation: 荧光检测系统包括被配置为产生激发光，光学透镜和光纤束的光源。 光学透镜被配置为将激发光聚焦到样品以发射荧光并收集荧光。 纤维束探针包括被配置为将激发光透射到光学透镜的发射光纤和被配置为传送所收集的荧光的第一接收光纤。 荧光检测系统还包括第一检测器，其被配置为检测由接收光纤传送的荧光以产生响应信号;以及处理单元，被配置为通过分析响应信号来确定关于样本的信息。 另外，还提出了荧光检测方法。