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    Macromolecular conjugate and method of producing it
    24.
    发明专利
    Macromolecular conjugate and method of producing it 审中-公开
    大分子结合体及其生产方法

    公开(公告)号：JP2009294216A

    公开(公告)日：2009-12-17

    申请号：JP2009172859

    申请日：2009-07-24

    Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

    Inventor： RUSSELL JOHN C

    IPC: A61K47/48 ,  G01N33/531 ,  A61K38/00 ,  A61K39/395 ,  A61P43/00 ,  C07K1/107 ,  C07K16/00 ,  C07K19/00 ,  G01N33/543 ,  G01N33/547

    CPC classification number: C07K1/1077 ,  C07K16/00 ,  G01N33/54353

    Abstract: PROBLEM TO BE SOLVED: To provide a new macromolecular conjugate useful for diagnostic assays and therapeutic agents. SOLUTION: The conjugate which is a composition comprising a population of conjugates, wherein each conjugate of the population includes a predetermined number of antibodies and the number of antibodies is between 2 and 30, includes three layers of macromolecules, wherein at least two of the three layers includes two or more macromolecules, and wherein the layers form a surface in three dimensions. The conjugate including a specific binding member, two or more end-point molecules, and two or more spacer molecules which substantially separate the end-point molecules. The method of producing a suspended or soluble macromolecular conjugate including binding of a first macromolecule to a solid via a stable, disruptable bond, stably linking of an additional macromolecule, and releasing of a macromolecular conjugate, and the macromolecular conjugate produced by the method. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供可用于诊断测定和治疗剂的新的大分子缀合物。 解决方案：缀合物，其是包含一组缀合物的组合物，其中群体的每个缀合物包含预定数量的抗体，抗体数目在2和30之间，包括三层大分子，其中至少两个 三层包括两个或更多个大分子，并且其中这些层在三维中形成表面。 包含特异性结合成员，两个或多个端点分子的缀合物和基本上分离端点分子的两个或更多个间隔分子。 制备悬浮或可溶性大分子缀合物的方法，其包括通过稳定的可断裂键与第一大分子与固体的结合，稳定连接另外的大分子和释放大分子缀合物，以及通过该方法产生的大分子缀合物。 版权所有（C）2010，JPO＆INPIT

    Semisynthetic analog immunomodulator of rapamycin (macrolide)
    27.
    发明专利
    Semisynthetic analog immunomodulator of rapamycin (macrolide) 有权
    RAPAMYCIN（MACROLIDE）的SEMISYNTHETIC ANALOG免疫调节剂

    公开(公告)号：JP2008156369A

    公开(公告)日：2008-07-10

    申请号：JP2008025068

    申请日：2008-02-05

    Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

    Inventor： OR YAT SUN ,  LULY JAY R ,  WAGNER ROLF

    IPC: C07D498/18 ,  A61K31/436 ,  A61P37/02 ,  A61P37/06

    CPC classification number: C07D498/18

    Abstract: PROBLEM TO BE SOLVED: To provide semisynthetic analogs of rapamycin as a therapeutic agent of immunomodulatory disorders.
    SOLUTION: Compounds such as semisynthetic analogs of rapamycin and pharmaceutically permissible salts, esters, amides, prodrugs and the like thereof are produced as a starting compound, which rapamycin is one of macrolide compounds obtained by fermentation and is a macrocyclic trien compound produced by Streptomyces hygroscopicus. Production of the intermediate useful for the methods, and use of the pharmaceutical compositions of the active ingredients and for treating immunomodulatory disorders, are provided.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供雷帕霉素的半合成类似物作为免疫调节障碍的治疗剂。 产生雷帕霉素的半合成类似物和药学上允许的盐，酯，酰胺，前药等化合物作为起始化合物，雷帕霉素是通过发酵获得的大环内酯化合物之一，并且是生产的大环三烯化合物 由吸水链霉菌（Streptomyces hygroscopicus） 提供了可用于该方法的中间体的制备以及活性成分的药物组合物的用途和用于治疗免疫调节性疾病。 版权所有（C）2008，JPO＆INPIT

    Photoacoustic analysis and photoacoustic analyzer for concentration measurement of analysis object in specimen tissue
    28.
    发明专利
    Photoacoustic analysis and photoacoustic analyzer for concentration measurement of analysis object in specimen tissue 有权
    光谱分析和光谱分析仪，用于样本组织中分析对象的浓度测量

    公开(公告)号：JP2008045938A

    公开(公告)日：2008-02-28

    申请号：JP2006220289

    申请日：2006-08-11

    Applicant: Abbott Lab ,  Toshiba Corp ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社 ,  株式会社東芝

    Inventor： KANAYAMA SHOICHI ,  HENMI KAZUHIRO ,  KHALIL OMAR S ,  BRENDA CALFIN ,  NAIL LOOMIS ,  YEH SHU-JEN ,  RONALD HOHS

    IPC: G01N21/00

    Abstract: PROBLEM TO BE SOLVED: To compensate an influence of a bulk tissue characteristic to noninvasive measurement of an analysis object concentration in an object tissue, relative to an ultrasonic pulse generated in the object tissue in a specimen and propagated. SOLUTION: This analysis method has a step a for irradiating a specimen portion with a near infrared laser pulse from laser sources 15-18, and generating the ultrasonic pulse in the object tissue; a step b for detecting the ultrasonic pulse by a detector 32, and generating the first signal; a step c for generating the ultrasonic pulse in the object tissue by using a laser pulse having the same wavelength and energy as in the step b during an arrangement period of a light absorbing material between the laser sources and the specimen portion so that the ultrasonic pulse is generated in the light absorbing material, propagated through the tissue, and detected by the detector; a step d for detecting the ultrasonic pulse generated in the light absorbing material, and generating the second signal; a step e for calculating the intensity ratio between the first and second signals relative to each wavelength; a step f for calculating an absorption coefficient of the analysis object from the intensity ratio and an optical characteristic of the light absorbing material; and a step g for calculating the concentration of the analysis object from the calculated absorption coefficient, and calculating a molar absorption coefficient of the analysis object. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：相对于在样本中的对象组织中产生的超声波脉冲，补偿体组织特征对对象组织中的分析对象浓度的无创测量的影响。 解决方案：该分析方法具有步骤a，用于用来自激光源15-18的近红外激光脉冲照射样本部分，并在对象组织中产生超声波脉冲; 用于通过检测器32检测超声波脉冲并产生第一信号的步骤b; 步骤c，用于在激光源和样本部分之间的光吸收材料的布置周期期间通过使用具有与步骤b相同的波长和能量的激光脉冲在对象组织中产生超声波脉冲，使得超声波脉冲 在光吸收材料中产生，传播通过组织，并由检测器检测; 步骤d，用于检测在吸光材料中产生的超声波脉冲，并产生第二信号; 用于计算相对于每个波长的第一和第二信号之间的强度比的步骤e; 用于根据光吸收材料的强度比和光学特性计算分析对象的吸收系数的步骤f; 以及从计算出的吸收系数计算分析对象的浓度并计算分析对象的摩尔吸光系数的步骤g。 版权所有（C）2008，JPO＆INPIT

    Non-invasive measuring device
    29.
    发明专利
    Non-invasive measuring device 有权
    非入侵测量设备

    公开(公告)号：JP2008005920A

    公开(公告)日：2008-01-17

    申请号：JP2006177127

    申请日：2006-06-27

    Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

    Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  YEH SHU-JEN

    IPC: A61B5/1495 ,  A61B5/1455

    Abstract: PROBLEM TO BE SOLVED: To improve the accuracy in calibration for the seasonal and physiological variation of tissue characteristics.
    SOLUTION: The non-invasive measuring device comprises a measuring probe 1, a light source 6, a photodetector, and a computer part 5 which controls the light source and photodetector to measure the information on the glucose in a subject and which estimates the glucose value based on a calibration model output from the photodetector. The computer part 5 determines the calibrated regression parameter of the calibration model, determines the estimated regression parameter of the calibration model by executing the regression operation for a reference measurement value based on the calibration model from an estimated data set, checks the accuracy in the non-invasive measurement from the difference between the glucose concentration estimated using the calibration model based on the result of the non-invasive measurement and the reference glucose concentration, and updates the calibration model.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提高组织特征的季节性和生理变化的校准精度。 解决方案：非侵入性测量装置包括测量探针1，光源6，光电检测器和计算机部分5，其控制光源和光电检测器以测量受试者中葡萄糖的信息，并且估计 基于从光电检测器输出的校准模型的葡萄糖值。 计算机部件5确定校准模型的校准回归参数，通过基于来自估计数据集的校准模型执行参考测量值的回归操作来确定校准模型的估计回归参数，检查非校准模型的准确性 使用基于非侵入性测量的结果的校准模型估计的葡萄糖浓度与参考葡萄糖浓度之间的差异进行侵入性测量，并更新校准模型。 版权所有（C）2008，JPO＆INPIT

    Noninvasive measurement method of glucose and noninvasive measurement instrument of glucose
    30.
    发明专利
    Noninvasive measurement method of glucose and noninvasive measurement instrument of glucose 有权
    葡萄糖和无血压测量仪器的非线性测量方法

    公开(公告)号：JP2007151618A

    公开(公告)日：2007-06-21

    申请号：JP2005347194

    申请日：2005-11-30

    Applicant: Abbott Lab ,  Toshiba Medical Systems Corp ,  アボット・ラボラトリーズAbbott Laboratories ,  東芝メディカルシステムズ株式会社

    Inventor： KANAYAMA SHOICHI ,  KHALIL OMAR S ,  JENG TZYY-WEN ,  YEH SHU-JEN

    IPC: A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/14532

    Abstract: PROBLEM TO BE SOLVED: To pursue temperature-induced glycolysis in the noninvasive measurement of glucose. SOLUTION: The change of glucose metabolism inside a skin nutrition capillary tube is induced, the change of localized reflectance optical signals in a plurality of distances between a light source and a detector and a plurality of wavelengths is measured as the function of the time of bringing a probe into contact with the skin, a time window capable of minimizing the influence of tissue and probe adaptation on signals is selected, and also the signals measured within the time window are used for the following calculation. One set of functions is calculated from a plurality of localized reflectance values in the plurality of distances between the light source and the detector and the plurality of wavelengths at a plurality of time intervals in at least two wavelengths within the time window, calibration relation between the combination of calculation functions and the glucose concentration of a living body is derived, and the calibration relation is used in order to predict the glucose concentration in body liquid in the following measurement. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：在葡萄糖的无创测量中追求温度诱导的糖酵解。 解决方案：诱导皮肤营养毛细管内的葡萄糖代谢的变化，测量光源和检测器之间的多个距离和多个波长的局部反射光信号的变化，作为 选择使探针与皮肤接触的时间，能够使组织的影响最小化的时间窗口和探针适应对信号的选择，并且在时间窗口内测量的信号也用于以下计算。 从时间窗内的至少两个波长的多个时间间隔，在光源和检测器之间的多个距离中的多个局部反射率值和多个波长之间计算一组功能，校准关系 导出计算功能与生物体的葡萄糖浓度的组合，并采用校准关系，以便在以下测定中预测体液中的葡萄糖浓度。 版权所有（C）2007，JPO＆INPIT

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