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公开(公告)号：CA2474316A1
公开(公告)日：2003-08-07
申请号：CA2474316
申请日：2003-01-28
Applicant: COGNETIX INC , UNIV UTAH RES FOUND
Inventor： JONES ROBERT M , PEMBERTON-GOODMAN KAREN E , TEMPLE DAVIS L JR , OLIVERA BALDOMERO M , MCINTOSH J MICHAEL
IPC: G01N33/50 , A01N1/02 , A61K31/135 , A61K31/138 , A61K31/616 , A61K31/727 , A61K38/00 , A61K38/17 , A61K38/48 , A61K38/49 , A61K45/00 , A61P9/00 , A61P43/00 , C07K14/435 , G01N33/15 , G01N33/566
Abstract: The invention relates to k-PVIIA-related conotoxins and their use as organ protecting agents, i.e., organ protectants. These conotoxins can be used for arresting, protecting or preserving an organ, such as a circulatory organ, a respiratory organ, a urinary organ, a digestive organ, a reproductive organ, an endocrine organ or a neurological organ. These conotoxins can also be used for arresting, protecting or preserving somatic cells.
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公开(公告)号：AU2002248553A1
公开(公告)日：2002-09-24
申请号：AU2002248553
申请日：2002-03-07
Applicant: UNIV UTAH RES FOUND , COGNETIX INC
Inventor： GARRETT JAMES E , OLIVERA BALDOMERO M , WALKER CRAIG S , JONES ROBERT M , WATKINS MAREN , MCINTOSH J MICHAEL
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公开(公告)号：AU7897501A
公开(公告)日：2002-02-05
申请号：AU7897501
申请日：2001-07-20
Applicant: COGNETIX INC , UNIV UTAH RES FOUND
Inventor： OLIVERA BALDOMERO M , LAYER RICHARD T , WATKINS MAREN , HILLYARD DAVID R , MCINTOSH J MICHAEL , SCHOENFELD ROBERT , JONES ROBERT M , NIELSEN JAKE
IPC: A61K38/00 , A61K38/17 , C07K14/435 , A61K38/04 , C07K7/08
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公开(公告)号：CA2396529A1
公开(公告)日：2001-07-12
申请号：CA2396529
申请日：2000-12-28
Applicant: UNIV UTAH RES FOUND , COGNETIX INC
Inventor： HILLYARD DAVID R , MCINTOSH J MICHAEL , LAYER RICHARD T , JONES ROBERT M , WATKINS MAREN , CARTIER G EDWARD , OLIVERA BALDOMERO M
IPC: G01N33/50 , A61K38/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/20 , A61P25/28 , A61P25/36 , A61P29/00 , A61P35/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07K14/435 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/17 , C12N15/12
Abstract: Published without an
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公开(公告)号：AU7596800A
公开(公告)日：2001-04-24
申请号：AU7596800
申请日：2000-09-21
Applicant: COGNETIX INC
Inventor： CORNELL-BELL ANN H , PEMBERTON KAREN E , TEMPLE DAVIS L JR , LAYER RICHARD T , MCCABE R TYLER , JONES ROBERT R
Abstract: The invention relates to uses of kappa-conotoxin PVIIA (kappa-PVIIA), analogs and derivatives for activating ATP-sensitive K + channels. The activation of ATP-sensitive K + channels is useful for opening K ATP channels which can be used to treat a wide range of disease and injury states, including cerebral and cardiac ischemia and asthma.
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Patent Agency Ranking
公开(公告)号：AU2732700A
公开(公告)日：2000-08-07
申请号：AU2732700
申请日：2000-01-21
Applicant: COGNETIX INC , UNIV UTAH RES FOUND
Inventor： OLIVERA BALDOMERO M , LAYER RICHARD T , WATKINS MAREN , HILLYARD DAVID R , MCINTOSH J MICHAEL , JONES ROBERT M
Abstract: The invention relates to relatively short peptides (termed alpha-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The alpha-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
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公开(公告)号：WO2006098764A2
公开(公告)日：2006-09-21
申请号：PCT/US2005/032129
申请日：2005-09-09
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION , COGNETIX, INC. , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , OLIVERA, Baldomero, M. , TERLAU, Heinrich , IMPERIAL, Julita, S. , GARRETT, James, E.
Inventor： OLIVERA, Baldomero, M. , TERLAU, Heinrich , IMPERIAL, Julita, S. , GARRETT, James, E.
IPC: A61K38/16 , C07K14/435
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The present invention is directed to conopeptides termed conkunitzins and their use for blocking the flow of potassium ions through voltage-gated potassium channels. In view of the Kunitz domain in the conkunitzins, they are also useful for inhibiting platelet aggregation and as protease inhibitors.
Abstract translation: 本发明涉及称为康尼他嗪的肽，以及它们用于阻断钾离子通过电压门控钾通道流动的用途。 鉴于康un嗪中的Kunitz结构域，它们也可用于抑制血小板聚集和蛋白酶抑制剂。
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公开(公告)号：WO2004108901A3
公开(公告)日：2006-03-09
申请号：PCT/US2004017903
申请日：2004-06-04
Applicant: COGNETIX INC , BULAJ GRZEGORZ , OLIVERA BALDOMERO M
Inventor： BULAJ GRZEGORZ , OLIVERA BALDOMERO M
CPC classification number: G06F19/22 , C40B50/02 , G01N33/6803 , G06F19/14
Abstract: The present invention relates to biotechnology and a method of preparing a library of nucleic acid or amino acid sequences that are phylogenetically related. The method includes the identification of conserved and non-conserved substitutions within a set of sequences and assaying related sequences including the conservative substitutions.
Abstract translation: 本发明涉及生物技术和制备与系统发育相关的核酸或氨基酸序列文库的方法。 该方法包括鉴定一组序列内的保守和非保守取代并测定包括保守取代的相关序列。
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公开(公告)号：WO2003063782A2
公开(公告)日：2003-08-07
申请号：PCT/US2003/002384
申请日：2003-01-28
Applicant: COGNETIX, INC. , UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： PEMBERTON-GOODMAN, Karen, E. , JONES, Robert, M. , TEMPLE, JR., Davis, L. , MCINTOSH, J., Michael , OLIVERA, Baldomero, M.
IPC: A61K
CPC classification number: A01N1/0226 , A01N1/02 , A61K38/17 , A61K38/49 , C07K14/435 , G01N2500/00 , A61K2300/00
Abstract: The invention relates to k-PVIIA-related conotoxins and their use as organ protecting agents, i.e., organ protectants. These conotoxins can be used for arresting, protecting or preserving an organ, such as a circulatory organ, a respiratory organ, a urinary organ, a digestive organ, a reproductive organ, an endocrine organ or a neurological organ. These conotoxins can also be used for arresting, protecting or preserving somatic cells.
Abstract translation: 本发明涉及k-PVIIA相关的芋螺毒素及其作为器官保护剂即器官保护剂的用途。 这些芋螺毒素可用于阻滞，保护或保存器官，如循环器官，呼吸器官，尿器官，消化器官，生殖器官，内分泌器官或神经器官。 这些芋螺毒素也可用于阻滞，保护或保存体细胞。
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公开(公告)号：WO0023092A9
公开(公告)日：2002-08-22
申请号：PCT/US9924380
申请日：1999-10-20
Applicant: COGNETIX INC , UNIV UTAH RES FOUND , SALK INST
Inventor： CRAIG A GREY , GRIFFIN DAVID , OLIVERA BALDOMERO M , WATKINS MAREN , HILLYARD DAVID R , IMPERIAL JULITA , CRUZ LOURDES J , WAGSTAFF JOHN D , LAYER RICHARD T , JONES ROBERT M , MCINTOSH J MICHAEL , MCCABE R TYLER
IPC: C12N15/09 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/08 , C07K9/00 , C07K14/435 , C07K14/575 , C12N15/12 , A61K38/10
CPC classification number: C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
Abstract translation: 本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及 到前体肽。 本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍 焦虑症，迟发性运动障碍，药物依赖性，惊恐发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和 神经精神药理学障碍。
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