公开(公告)号：US20130248695A1

公开(公告)日：2013-09-26

申请号：US13882466

申请日：2011-10-28

Applicant: Duncan Macintyre ,  Ash Kaushal

Inventor： Duncan Macintyre ,  Ash Kaushal

IPC: G01N21/17

CPC classification number: G01N21/17 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  G01N21/253 ,  G01N21/255

Abstract: Methods and apparatus for identifying an analyte in a sample are provided. The apparatus comprises an electromagnetic radiation (EMR) source in optical communication with a receptor. The receptor for receiving a sample and detecting if the sample has been presented to the receptor in a predefined manner. The receptor further directing the EMR received from the EMR source to the sample. The apparatus also comprises a detector in optical communication with the receptor, the detector for capturing transmitted, reflected, scattered EMR, or a combination thereof from the sample received from the receptor. The apparatus further comprises a user interface for presenting information obtained from the sample and the receptor, and the characteristics of one or more analytes in the sample, and a communications unit in operative association with the detector for transmitting the characteristics of one or more analytes in the sample to a processor or spectrograph.

Abstract translation: 提供了用于鉴定样品中分析物的方法和装置。 该装置包括与受体光学通信的电磁辐射源（EMR）源。 用于接收样品并检测样品是否以预定方式呈递给受体的受体。 受体进一步将从EMR源接收的EMR引导到样品。 该装置还包括与受体光学通信的检测器，用于从接收器接收的样本捕获发射的，反射的，散射的EMR或其组合的检测器。 该装置还包括用于呈现从样本和受体获得的信息的用户界面以及样本中的一种或多种分析物的特征，以及与检测器可操作地相关联的通信单元，用于将一个或多个分析物的特征传输到 样品到处理器或光谱仪。

公开(公告)号：US20130215426A1

公开(公告)日：2013-08-22

申请号：US13814188

申请日：2011-08-04

Applicant: Ash Kaushal ,  Duncan MacIntyre

Inventor： Ash Kaushal ,  Duncan MacIntyre

IPC: G01N21/59 ,  G01N21/55

CPC classification number: G01N21/59 ,  G01N21/31 ,  G01N21/55 ,  G01N2201/0221

Abstract: A photo-spectroscopic analytic device is given for detecting analytes in a sample. The analyte may be microbial pathogen, a food sample, a sample of a body fluid, water, or a combination thereof. The device comprises an electromagnetic radiation (EMR) source in operative communication with one or more optic inputs, one or more receptors for receiving one or more sample holders, each receptor comprising one or more of the optic inputs which are operatively coupled to one or more optic outputs thereby forming an optic input-optic output pair. Each of the receptors may comprise different cross-sectional profiles corresponding to cross-sectional profiles of the sample holders.

Abstract translation: 给出了光谱分析装置，用于检测样品中的分析物。 分析物可以是微生物病原体，食物样品，体液样品，水或其组合。 该装置包括与一个或多个光学输入端可操作地通信的电磁辐射（EMR）源，用于接收一个或多个样本保持器的一个或多个受体，每个受体包括一个或多个光学输入，其可操作地耦合到一个或多个 从而形成光输入 - 光输出对。 每个受体可以包括对应于样品保持器的横截面轮廓的不同横截面轮廓。

公开(公告)号：US07933005B2

公开(公告)日：2011-04-26

申请号：US11562306

申请日：2006-11-21

Applicant: Duncan MacIntyre ,  Ash Kaushal ,  Paul Endersby

Inventor： Duncan MacIntyre ,  Ash Kaushal ,  Paul Endersby

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/151 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359

Abstract: A device for measuring a compound with in a sample both non-invasively and invasively is provided. The devise comprised a source of electromagnetic radiation (EMR) operatively coupled to a power source, one or more receptors and a detector. The one or more receptors shaped to receive a body part and a sample holder and optically coupled to the source of EMR by one or more radiation guiding elements. The radiation guiding element comprising an input in operable association with the source of EMR, and an output in operable association with a detector and coupled to a processing system.

Abstract translation: 提供了一种用于在非侵入式和非侵入式中测量样品中的化合物的装置。 该设备包括可操作地耦合到电源，一个或多个受体和检测器的电磁辐射源（EMR）。 所述一个或多个受体被成形为接收身体部位和样本保持器，并通过一个或多个辐射引导元件光耦合到EMR源。 所述辐射引导元件包括与所述EMR源可操作地相关联的输入，以及与检测器可操作地相关联并耦合到处理系统的输出。

公开(公告)号：US07328052B2

公开(公告)日：2008-02-05

申请号：US10943737

申请日：2004-09-17

Applicant: James Samsoondar ,  Duncan MacIntyre ,  Ashwani Kaushal

Inventor： James Samsoondar ,  Duncan MacIntyre ,  Ashwani Kaushal

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  A61B2562/0238

Abstract: The present invention provides an apparatus and a method for identifying the risk of a clinical condition in a human or animal by correlating Near Infrared (NIR) absorbance spectral data with one or several parameters including a concentration of one or more substances in the skin, a concentration of one or more substances in skin plus subdermal tissue, a score derived from one or more clinical tests like a stress test on a treadmill, coronary angiography, or intravascular coronary ultrasound. The method determines the concentration of a compound in the skin of a human or animal and comprises the steps of placing a part of the skin against a receptor, directing electromagnetic radiation (EMR) from the near-infrared spectrum onto the skin, measuring a quantity of EMR reflected by, or transmitted through, the skin with a detector; and performing a quantitative mathematical analysis of the quantity of EMR to determine the concentration of the compound, for example free and esterfied cholesterol. An example of a clinical condition is cardiovascular disease.

Abstract translation: 本发明提供了一种用于通过将近红外（NIR）吸收光谱数据与包括皮肤中的一种或多种物质的浓度的一个或几个参数相关联来鉴定人或动物的临床状况的风险的装置和方法， 皮肤中的一种或多种物质和皮下组织的浓度，来自一项或多项临床试验的得分，如跑步机上的压力试验，冠状动脉造影或血管内冠状动脉超声。 该方法确定化合物在人或动物皮肤中的浓度，包括以下步骤：将一部分皮肤放置在受体上，将电磁辐射（EMR）从近红外光谱引导到皮肤上，测量数量 由检测器反射或透过皮肤的EMR; 并对EMR的量进行定量数学分析以确定化合物的浓度，例如游离和酯化的胆固醇。 临床病症的一个例子是心血管疾病。

公开(公告)号：US07198955B1

公开(公告)日：2007-04-03

申请号：US09367859

申请日：1997-10-16

Applicant: James Samsoondar ,  Duncan MacIntyre

Inventor： James Samsoondar ,  Duncan MacIntyre

IPC: G01N33/72 ,  G01N33/20 ,  G01N33/62 ,  G01N33/68 ,  G01N33/48 ,  C12Q1/00

CPC classification number: G01N33/721 ,  G01N33/84 ,  G01N33/96 ,  G01N2496/15 ,  Y10T436/14 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/145555 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/148888 ,  Y10T436/15 ,  Y10T436/193333 ,  Y10T436/25125

Abstract: A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and uses it to correct for its effect, if any, on a measured analyte concentration, e.g., serum/plasma total protein. Further, the method allows for the determination of the concentration of true hemoglobin in the presence of blood substitutes. The method is carried out in respect of samples contained in a primary or secondary labelled tube, or a pipette tip used to dispense serum or plasma in a blood analyzer.

Abstract translation: 公开了一种方法，其中血清或血浆样品中的血液代用品如交联血红蛋白的浓度被快速且准确地识别和定量。 该方法还采用血液替代品的测量浓度，并且使用它来校正其在测量的分析物浓度（例如血清/血浆总蛋白）上的效果（如果有的话）。 此外，该方法允许在存在血液代用品时确定真实血红蛋白的浓度。 该方法对于包含在主要或次要标记管中的样品或用于在血液分析仪中分配血清或血浆的移液管末端进行。

公开(公告)号：USD533095S1

公开(公告)日：2006-12-05

申请号：US29223506

申请日：2005-02-15

Applicant: Ashwani Kaushal ,  Duncan MacIntyre

Designer： Ashwani Kaushal ,  Duncan MacIntyre

公开(公告)号：US20050019936A1

公开(公告)日：2005-01-27

申请号：US10845227

申请日：2004-05-14

Applicant: James Samsoondar ,  Duncan MacIntyre

Inventor： James Samsoondar ,  Duncan MacIntyre

IPC: B01L3/00 ,  G01N21/03 ,  G01N21/27 ,  G01N21/31 ,  G01N21/47 ,  G01N33/72 ,  G01N31/00

CPC classification number: G01N21/274 ,  B01L3/508 ,  B01L2300/043 ,  B01L2300/0809 ,  G01N21/03 ,  G01N21/31 ,  G01N21/4785 ,  G01N33/72

Abstract: A method and apparatus for measuring Tot-Hb in a sample are provided. The method comprises collecting absorbance measurements of a sample using a spectroscopic apparatus that comprises a first primary calibration algorithm for one of Oxy-Hb, “Oxy-Hb plus Deoxy-Hb”, or “Total-Hb minus Met-Hb” and a second primary calibration algorithm for one or more than one of Met-Hb, Carboxy-Hb, or Sulf-Hb, or comprising a third primary calibration algorithm obtained by adding terms of the first primary calibration algorithm and the second primary calibration algorithm together. Followed by predicting either a first value for one of Oxy-Hb, “Oxy-Hb plus Deoxy-Hb,” or “Total-Hb minus Met-Hb” and predicting second value for one or more than one of Met-Hb, Carboxy-Hb, or Sulf-Hb in the sample and add the first and second value together, or predicting a value for Total-Hb.

Abstract translation: 提供了用于测量样品中的Tot-Hb的方法和装置。 该方法包括使用分光装置收集样品的吸光度测量值，该分光装置包括用于Oxy-Hb，“Oxy-Hb加脱氧-Hb”或“总-Hb减去Met-Hb”之一的第一主校准算法， 一个或多于一个Met-Hb，Carboxy-Hb或Sulf-Hb的一次校准算法，或包括通过将第一个主校准算法和第二个主校准算法的项相加在一起而获得的第三个主校准算法。 随后预测Oxy-Hb，“Oxy-Hb加脱氧-Hb”或“总-Hb减去Met-Hb”中的一个的第一值，并且预测Met-Hb，羧基中的一个或多于一个的第二值 -Hb或Sulf-Hb，并将第一个和第二个值添加到一起，或者预测Total-Hb的值。