公开(公告)号：WO2010043847A1

公开(公告)日：2010-04-22

申请号：PCT/GB2009/002350

申请日：2009-10-02

Applicant: HABIB, Nagy, A. ,  GORDON, Myrtle

Inventor： HABIB, Nagy, A. ,  GORDON, Myrtle

IPC: A61K35/12 ,  A61P35/00 ,  A61P17/06 ,  A61P17/12 ,  A61P37/00

CPC classification number: A61K35/12

Abstract: The invention provides an apoptosis-modulating cell-free composition comprising conditioned extracellular medium of a stem cell and uses thereof, particularly therapeutic uses. Also provided is a method of obtaining such a composition and an in vitro method of modulating apoptosis.

Abstract translation: 本发明提供了一种细胞凋亡调节无细胞组合物，其包含干细胞的调节细胞外培养基及其用途，特别是治疗用途。 还提供了获得这样的组合物和调节凋亡的体外方法的方法。

公开(公告)号：WO2008084239A2

公开(公告)日：2008-07-17

申请号：PCT/GB2008/000084

申请日：2008-01-11

Applicant: HABIB MEDICAL LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61B18/14

CPC classification number: A61B18/082 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1495 ,  C08L2201/12

Abstract: Devices suitable for insertion into a hollow anatomical structure within a patient for the purpose of ablating tissue within or surrounding the hollow structure so as to induce occlusion of the hollow structure are provided. The devices are in the form of guidewires with functional tips, that comprise at least one heating module, at their distal ends. The devices of the invention are suitable for occluding hollow anatomical structures selected from vasculature or from non-vascular ducts and tubes, via percutaneous, laparoscopic or endoscopic routes of access. Methods of using the devices in the treatment of patients are also described.

Abstract translation: 提供了适于插入到患者体内的中空解剖结构中的装置，用于在中空结构内或周围消融组织以便引起中空结构的闭塞。 这些装置是具有功能尖端的导线的形式，其在其远端包括至少一个加热模块。 本发明的装置适合于通过经皮，腹腔镜或内窥镜进入途径闭塞从脉管系统或非血管导管和管中选择的中空解剖结构。 还描述了在患者治疗中使用该装置的方法。

公开(公告)号：WO2008009972A2

公开(公告)日：2008-01-24

申请号：PCT/GB2007/002793

申请日：2007-07-23

Applicant: EMCISION LIMITED ,  HABIB, Nagy ,  PACEY, Andrew, Robert

Inventor： HABIB, Nagy ,  PACEY, Andrew, Robert

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/1425 ,  A61B2018/144 ,  A61B2018/1475

Abstract: A flexible RF device (1) can be deployed through a flexible endoscope. An electrode structure has a central electrode (12) and outer electrode (11). Flexible electrodes (30), circular electrodes (51, 53) and circular loop assemblies (55, 56) with different diameters are also disclosed, as well a tweezer electrodes (41) with pads (43) for increasing contact area. Retractable electrodes (100) are also disclosed.

Abstract translation: 柔性射频装置（1）可以通过柔性内窥镜部署。 电极结构具有中心电极（12）和外电极（11）。 还公开了具有不同直径的柔性电极（30），圆形电极（51,53）和圆环组件（55,56），以及具有用于增加接触面积的衬垫（43）的镊子电极（41）。 还公开了伸缩电极（100）。

公开(公告)号：WO2006127482A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/019506

申请日：2006-05-19

Applicant: BIOENVISION, INC. ,  WOOD, Christopher ,  HABIB, Nagy

Inventor： WOOD, Christopher ,  HABIB, Nagy

IPC: A61K31/538 ,  A61K31/5415 ,  A61P31/12 ,  A61P31/22

CPC classification number: A61K31/538 ,  A61K31/5415 ,  Y02A50/467

Abstract: A method for using thiazine dyes, especially methylene blue or methylene blue derivatives, in an immediate or controlled release formulation, alone or in combination with low levels of light or other drugs, to selectively inactivate or inhibit hepatitis infection, has been developed. Clinical trial results demonstrate efficacy in a human clinical trial for treatment of hepatitis C by oral administration of methylene blue immediate release formulation, in a dosage of 65 mg twice daily, over a period of at least 100 days. A method for using thiazine dyes, especially methylene blue or methylene blude derivatives, in an immediate or controlled release formulation, alone or in combination with low levels of light or other drugs, to prevent or decrease reactivation of viruses, is also described. The preferred class of patient is infected with, or has been exposed to, viruses such as Herpes simplex virus type 1 & 2, Varicella zoster virus, Epstein-Barr virus, Cytomegalovirus, and Herpes virus type 6 & 7, Adenovirus, and Human polyoma viruses, e.g. JC virus and BK virus. In one embodiment the thiazine dye is administered to a patient experiencing symptoms or disease caused by reactivation of a virus. In a preferred embodiment the thiazine dye is administered to a patient at risk for or experiencing symptoms or disease caused by reactivation of a virus, prior to or during immunosuppression or chemotherapy.

Abstract translation: 已经开发了将立体或控制释放制剂中的噻嗪染料，特别是亚甲基蓝或亚甲基蓝衍生物单独或与低水平的光或其它药物组合使用以选择性失活或抑制肝炎感染的方法。 临床试验结果表明，通过在至少100天的时间内口服给予亚甲基蓝立即释放制剂的人临床试验用于治疗丙型肝炎的疗效，剂量为65mg，每日两次。 还描述了在即时或控制释放制剂中单独或与低水平的光或其它药物组合使用噻嗪染料，特别是亚甲基蓝或亚甲基引发衍生物以预防或减少病毒再活化的方法。 患者的优选类别被感染或已经暴露于病毒如1型和2型单纯疱疹病毒，水痘带状疱疹病毒，爱泼斯坦 - 巴尔病毒，巨细胞病毒和6型和7型疱疹病毒，腺病毒和人多瘤病毒 病毒，例如 JC病毒和BK病毒。 在一个实施方案中，将噻嗪染料施用于经历病毒再活化引起的症状或疾病的患者。 在优选的实施方案中，在免疫抑制或化学疗法之前或期间，向处于或经历由病毒再活化引起的症状或疾病的风险的患者施用噻嗪染料。

公开(公告)号：WO1990015630A1

公开(公告)日：1990-12-27

申请号：PCT/GB1990000942

申请日：1990-06-19

Applicant: HABIB, Nagy, Adly

IPC: A61M01/12

CPC classification number: F04B43/082 ,  A61B2017/00685 ,  A61M1/101 ,  A61M1/1037 ,  A61M1/1041 ,  A61M1/1062 ,  A61M1/122

Abstract: A provision of improving the flow of blood through a region of increased impedance is disclosed. The provision comprises assisting blood flow is said region by means of a pump placed in or around a blood vessel supplying blood to said area, and acting to pump blood in the required direction. The pump (1) comprises, in one embodiment, a housing (2) annularly surrounding a compressible conduit (3), said housing (2) containing a plurality of flexible inflatable containers (4) mounted for contact with said conduit (3) (e.g. a blood vessel) and means for effecting sequential inflation and deflation of said containers (4) so as to create a peristaltic pumping effect.

Abstract translation: 公开了通过增加阻抗的区域改善血液流动的设置。 该设置包括通过放置在向该区域供血的血管中或周围的泵来帮助所述区域的血液流动，并且用于沿所需方向抽血。 在一个实施例中，泵（1）包括围绕可压缩导管（3）的壳体（2），所述壳体（2）包含多个柔性的可充气容器（4），所述柔性充气容器安装成与所述导管（3） 例如血管）和用于实现所述容器（4）的顺序充气和放气的装置，以便产生蠕动泵送效果。

公开(公告)号：WO2008084252A3

公开(公告)日：2008-07-17

申请号：PCT/GB2008/000102

申请日：2008-01-11

Applicant: EMCISION LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61F2/84

Abstract: A removable stent (10) has guide member pairs (16) and loops (20), the guide member pairs being used to align arms of a framework (28) which may expand or collapse the stent. The stent can be retained inside an outer sheath (30) of a catheter (32) with a collapsible filter net (34). Magnetic stents and stents with springs (170) and hinges (156) are also provided.

公开(公告)号：WO2008084244A2

公开(公告)日：2008-07-17

申请号：PCT/GB2008/000093

申请日：2008-01-11

Applicant: EMCISION LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61B18/04 ,  A61B18/14 ,  A61F2/06

CPC classification number: A61B18/1477 ,  A61B18/1492 ,  A61B2018/143 ,  A61F2002/9522 ,  A61F2002/9528 ,  A61F2002/9534

Abstract: A device for treating diseased tissue includes a plurality of needles (21) connected to a central shaft (22) via a hub (23), the connection of each needle to the hub including a hinge mechanism so that the needles can open out once the hub is pushed out of a catheter. RF power can be applied so that tissue can be treated via electrodes defined by the needles.

Abstract translation: 用于治疗患病组织的装置包括经由毂（23）连接到中心轴（22）的多个针（21），每个针与轮毂的连接包括铰链机构，使得针可以一旦打开 轮毂被推出导管。 可以施加RF功率，使得可以通过由针定义的电极来处理组织。

公开(公告)号：WO2007135437A1

公开(公告)日：2007-11-29

申请号：PCT/GB2007/001921

申请日：2007-05-23

Applicant: EMCISION LIMITED ,  PACEY, Andrew ,  HABIB, Nagy

Inventor： PACEY, Andrew ,  HABIB, Nagy

IPC: A61B18/04 ,  A61F2/06

CPC classification number: A61F2/91 ,  A61B18/1492 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61F2/90 ,  A61F2/95 ,  A61F2230/0067

Abstract: A catheter (4) may be introduced into the body of a patient to provide electromagnetic power, such as RF power, directly to a stent (2) to cause heating of surrounding tissue for ablation. The stent may have a conducting portion (14) and insulated portions (13). Struts (15) on the catheter may be deployed by a balloon (103) to contact the stent. The stent may have radial or sector segments (16) which may be individually powered for treating asymmetric tumours.

Abstract translation: 可以将导管（4）引入患者体内以将电力（例如RF功率）直接提供给支架（2）以引起周围组织的加热以进行消融。 支架可以具有导电部分（14）和绝缘部分（13）。 导管上的支柱（15）可以由球囊（103）展开以接触支架。 支架可以具有径向或扇形段（16），其可单独供电用于治疗不对称肿瘤。

公开(公告)号：WO2007135431A3

公开(公告)日：2007-11-29

申请号：PCT/GB2007/001914

申请日：2007-05-23

Applicant: EMCISION LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61B17/08 ,  A61B18/18

Abstract: A device is provided that is suitable for percutaneous insertion into a hollow vessel, such as a blood vessel, within the body of a patient for purpose of causing endoluminal closure of the vessel at a specified therapeutic site in the body of a patient. The device suitably is in the form of a catheter that is slidably mounted on a guidewire. The catheter may comprise one or more heating modules, as well as one or more extendable structures located on the device and optionally on the associated guidewire, that lead thermal ablation of the vessel walls and subsequent collapse of the vessel. The catheter can function alone or in cooperation with an associated guidewire to induce sealing of the vessel. Methods of using the catheter to treat lesions such as tumours or haemorrhages are also described.

公开(公告)号：WO2005113781A3

公开(公告)日：2006-11-23

申请号：PCT/GB2005002016

申请日：2005-05-23

Applicant: GOT A GENE AB ,  HABIB NAGY ,  CENTRE NAT RECH SCIENT ,  BOULANGER PIERRE ,  LINDHOLM LEIF ,  MAGNUSSON MARIA ,  HONG SAW SEE ,  ROSA-CALATRAVA MANUEL

Inventor： BOULANGER PIERRE ,  LINDHOLM LEIF ,  MAGNUSSON MARIA ,  HONG SAW SEE ,  ROSA-CALATRAVA MANUEL

IPC: C12N15/861 ,  A61K47/48 ,  C07K14/075 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K47/64 ,  A61K2039/5256 ,  C07K2319/33 ,  C07K2319/50 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10345 ,  C12N2810/50

Abstract: The present invention relates to a vector comprising a nucleic acid molecule and a peptide or peptide derivative, said peptide or peptide derivative comprising a peptide of general Formula (I) R 1 - R

Abstract translation: 本发明涉及包含核酸分子和肽或肽衍生物的载体，所述肽或肽衍生物包含通式（I）的肽R 1 - [R