公开(公告)号：EP3224754A1

公开(公告)日：2017-10-04

申请号：EP15863918.7

申请日：2015-11-23

Applicant: Howard University

Inventor： KIM, Charles J.

IPC: G06F21/50 ,  G06F11/20

CPC classification number: G06F21/567 ,  G05B9/02 ,  G06F11/1487 ,  G06F11/1641 ,  G06F11/165 ,  G06F21/552

Abstract: A redundant and diverse secondary control system mirrors a primary control system but has some fundamental structural difference as compared to the primary control system to prevent a spread of a security breach from the primary control system to the secondary control system. The secondary control system may operate on different hardware built on different software written with different programming language as compared to the primary control system while performing the same function as that of the primary system. By hardware coding the algorithm to produce actuation signals, software based viruses and worms cannot interfere with the secondary control system's operation. A monitor device receives actuation signals from both the primary and secondary controls signals to determine whether an error occurred and to provide correct actuation signals to the controlled system.

Abstract translation: 冗余和多样化的辅助控制系统反映了主要控制系统，但与主要控制系统相比具有一些基本的结构差异，以防止安全漏洞从主要控制系统扩散到辅助控制系统。 与主控制系统相比，次控制系统可以在建立在用不同编程语言编写的不同软件上的不同硬件上运行，同时执行与主系统相同的功能。 通过对算法进行硬件编码以生成驱动信号，基于软件的病毒和蠕虫不会干扰辅助控制系统的操作。 监视器装置接收来自主控制信号和辅助控制信号的致动信号，以确定是否发生错误并向受控系统提供正确的致动信号。

公开(公告)号：EP2691017B1

公开(公告)日：2016-03-23

申请号：EP12764542.2

申请日：2012-03-29

Applicant: Howard University

Inventor： ANDERSON, John M. M.

IPC: A61B5/026

CPC classification number: A61B6/5217 ,  A61B5/02755 ,  A61B6/037 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  G06F19/00 ,  G06T7/0016 ,  G06T2207/10104 ,  G06T2207/30104 ,  G16H50/50

Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.

公开(公告)号：EP2847601A1

公开(公告)日：2015-03-18

申请号：EP13787570.4

申请日：2013-05-06

Applicant: Howard University

Inventor： KIM, Charles J.

IPC: G01R31/08 ,  G01R31/12 ,  G01R31/02

CPC classification number: G01R31/083

Abstract: A distance from a measurement point to a fault in a three-phase circuit is determined. The measurement point is located at an output of a power sub-station and the three phase circuit has a loop circuit having an associated net fault line current and a ground current. A derivative of the net fault line current of the loop circuit as measured from the measurement point is calculated. An uncompensated distance to the sub-cycle fault using at least the derivative of the net fault current is determined, and configured, to compensate for the ground current of the loop circuit. The compensation is applied to the uncompensated distance to produce a compensated distance to the sub-cycle fault.

公开(公告)号：EP2712361A1

公开(公告)日：2014-04-02

申请号：EP12789195.0

申请日：2012-05-18

Applicant: Howard University

Inventor： BAKARE, Oladapo ,  DENMEADE, Samuel, Ray ,  AKINBOYE, Emmanuel

IPC: C07D455/08

CPC classification number: C07D455/08 ,  C07D401/06 ,  C07K7/06

Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2′-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

Abstract translation: 本文提供了可作为前药的依米丁衍生物的化合物，其在特定的细胞条件下选择性地经历活化以释放吐根碱。 一方面，通过用可在癌症/肿瘤微环境中通过水解选择性去除的部分衍生N2'-位置，将阻断基团结合到依米丁分子上。 这种化合物比依米丁细胞毒性小，并且在非癌细胞中基本无活性。 在一个方面，本文所述的化合物可用于治疗转移性和非转移性癌症，包括例如乳腺癌，前列腺癌，肺癌和白血病。

公开(公告)号：EP2700199A2

公开(公告)日：2014-02-26

申请号：EP12774777.2

申请日：2012-04-13

Applicant: Howard University

Inventor： KIM, Charles J.

IPC: H04L12/26 ,  H04L27/00

CPC classification number: G01R31/02 ,  H04B10/0771 ,  H04L1/243 ,  H04L25/0266 ,  H04L25/0268 ,  H04L27/02 ,  H04L27/10 ,  H04L27/18 ,  H04L41/0677 ,  H04L2001/0094 ,  Y04S40/166

Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.

公开(公告)号：EP2529417A2

公开(公告)日：2012-12-05

申请号：EP11737739.0

申请日：2011-01-28

Applicant: Howard University

Inventor： BATES, Clayton W., Jr.

IPC: H01L31/109 ,  H01L31/09

CPC classification number: H01L31/035209 ,  H01J1/34 ,  H01J31/49 ,  H01L31/108

Abstract: An infrared external photoemissive detector can have an n-p heterojunction comprising an n-type semiconductor layer and a p-layer; the n-layer semiconductor comprising doped silicon embedded with nanoparticles forming Schottky barriers; and the p-layer is a p-type diamond film. The nanoparticles can be about 20 - 30 atomic percentage metal particles (such as silver) having an average particle size of about 5 - 10 nm. The p-layer can have a surface layer that has a negative electron affinity. The n-layer can be in the range of about 3 µm to 10 µm thick, and preferably about 3 µm thick. The doped silicon can be doped with elements selected from the list consisting of phosphorus and antimony.

Abstract translation: 红外外部发光检测器可以具有包括n型半导体层和p层的n-p异质结; 所述n层半导体包括掺杂有形成肖特基势垒的纳米颗粒的掺杂硅; p层是p型金刚石膜。 纳米颗粒可以是平均粒径约5-10nm的约20-30原子百分比的金属颗粒（如银）。 p层可以具有具有负电子亲和力的表面层。 n层可以在约3μm至10μm厚的范围内，优选约3μm厚。 掺杂的硅可掺杂有选自磷和锑的元素。

公开(公告)号：EP2504767A2

公开(公告)日：2012-10-03

申请号：EP10833979.7

申请日：2010-11-24

Applicant: Howard University

Inventor： GLOSTER, JR., Clay S. ,  GAY, Wanda D. ,  AMOO, Michaela E.

IPC: G06F13/14 ,  G06F13/38

CPC classification number: G06F15/7871 ,  G06F15/7885

Abstract: An integrated circuit device (200) is provided comprising a circuit board (210) and one or more digital signal processors (100) implemented thereon. The digital signal processor (100) comprises a data unit (120) comprising a function core (124) configured to perform a specific mathematical expression in order to perform at least a portion of a specific application and an instruction memory (122) storing one or more instructions configured to send commands to the control unit (110) and the data unit to perform the specific application, and a control unit configured to control the flow of data between a plurality of memory banks (130, 140) and the function core for performing the specific application, and the plurality of memory banks coupled to each of the one or more digital signal processors and comprising at least two or more local memory banks (130) integrated onto the circuit board.

公开(公告)号：EP2419130A1

公开(公告)日：2012-02-22

申请号：EP10765117.6

申请日：2010-04-14

Applicant: Howard University ,  The United States Of America, Department Of Health And Human Services

Inventor： TAI, Stanley Shih-Peng ,  LEE, Che-Hung Robert

IPC: A61K39/09 ,  A61K39/095

CPC classification number: A61K39/095 ,  A61K39/092 ,  A61K2039/6068 ,  A61K2039/70 ,  Y10S424/831

Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S.
pneumoniae and
N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA ("rPsaA") from
S. pneumoniae and capsular polysaccharide from
N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.

公开(公告)号：EP2356475A1

公开(公告)日：2011-08-17

申请号：EP09824037.7

申请日：2009-10-23

Applicant: Howard University

Inventor： KIM, Charles, J.

IPC: G01R31/02

CPC classification number: G01R31/024 ,  G01R31/008 ,  G01R31/086 ,  H04B3/46 ,  H04B3/546

Abstract: Signals are transmitted from at least one transmitter that is positioned in an electrical network. The signals that have been transmitted are received by the at least one single receiver at a single receiver positioned within the electrical network. At the single receiver, the received signals are analyzed and a determination from the analyzing the received signals is made as to whether a fault has occurred in the electrical network.

公开(公告)号：EP2265117A1

公开(公告)日：2010-12-29

申请号：EP09732857.9

申请日：2009-04-14

Applicant: Howard University

Inventor： NEKHAI, Sergei ,  KOVALSKYY, Dmytro, B.

IPC: A01N43/46

CPC classification number: C07D219/04 ,  C07D221/16 ,  C07D409/06

Abstract: Inhibitors of Protein Phosphatase-l have been shown to slow replication of HIV -1. Inhibitors of PP 1 and their use for treatment or prevention of HIV -1 infections are disclosed.