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    Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
    21.
    发明授权
    Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells 有权
    用于定量外周血细胞上HLA-DR和CD11b表达的方法和试剂

    公开(公告)号：US06423505B1

    公开(公告)日：2002-07-23

    申请号：US09406013

    申请日：1999-09-24

    Applicant: Kenneth A. Davis

    Inventor： Kenneth A. Davis

    IPC: G01N3353

    CPC classification number: G01N33/56977 ,  C07K16/2896 ,  G01N33/56972 ,  G01N2333/70539 ,  G01N2333/70553 ,  Y10S435/961 ,  Y10S435/962 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/808 ,  Y10S436/826

    Abstract: Improved methods, reagents, and kits for quantitation of HLA-DR and/or CD11b expression on peripheral blood cells are presented. Inclusion of a lysosomotropic amine, such as chloroquine, during staining stabilizes HLA-DR and CD11b expression. Use of a novel anti-CD14 conjugate, anti-CD14-PerCP/CY5.5, permits the ready discrimination of monocytes. The improved methods, reagents, and kits may be used to assess immune competence, and to direct and monitor immunostimulatory therapies in septic patients exhibiting monocyte deactivation.

    Abstract translation: 提出了用于定量外周血细胞上HLA-DR和/或CD11b表达的改进的方法，试剂和试剂盒。 在染色期间包含溶酶体胺，如氯喹，稳定了HLA-DR和CD11b的表达。 使用抗CD14结合物，抗CD14-PerCP / CY5.5，可以准确鉴别单核细胞。 可以使用改进的方法，试剂和试剂盒来评估免疫能力，并且指导和监测显示单核细胞失活的脓毒症患者的免疫刺激疗法。

    Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
    22.
    发明授权
    Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells 有权
    用于定量外周血细胞上HLA-DR表达的方法和试剂

    公开(公告)号：US06376202B1

    公开(公告)日：2002-04-23

    申请号：US09645966

    申请日：2000-08-24

    Applicant: Kenneth A. Davis

    Inventor： Kenneth A. Davis

    IPC: G01N33533

    CPC classification number: C07K16/2896 ,  G01N33/56977 ,  Y10S435/975 ,  Y10S436/80

    Abstract: Improved methods, reagents, and kits for quantitation of HLA-DR expression on peripheral blood cells, particularly peripheral blood monocytes, are presented. Inclusion of a lysosomotropic amine, such as chloroquine, during staining stabilizes HLA-DR expression, and use of a novel anti-CD14 conjugate, anti-CD14-PerCP/CY5.5, permits the ready discrimination of monocytes. The improved methods, reagents, and kits may be used to assess immune competence, and to direct and monitor immunostimulatory therapies in septic patients exhibiting monocyte deactivation.

    Abstract translation: 提出了用于定量外周血细胞特别是外周血单核细胞上的HLA-DR表达的改进的方法，试剂和试剂盒。 在染色过程中包含溶酶体胺如氯喹可稳定HLA-DR表达，并且使用抗CD14结合物，抗-CD14-PerCP / CY5.5，可以快速鉴别单核细胞。 可以使用改进的方法，试剂和试剂盒来评估免疫能力，并且指导和监测显示单核细胞失活的脓毒症患者的免疫刺激疗法。

    Non-volatile storage module for a controller
    24.
    发明授权
    Non-volatile storage module for a controller 失效
    用于控制器的非易失性存储模块

    公开(公告)号：US4131942A

    公开(公告)日：1978-12-26

    申请号：US758111

    申请日：1977-01-10

    Applicant: Kenneth Gillett ,  Edward L. Steiner ,  Kenton W. Fiske ,  Kenneth A. Davis ,  William P. Kukucka ,  Thomas Criswell ,  Philip Richardson

    Inventor： Kenneth Gillett ,  Edward L. Steiner ,  Kenton W. Fiske ,  Kenneth A. Davis ,  William P. Kukucka ,  Thomas Criswell ,  Philip Richardson

    IPC: G06F12/16 ,  G03G21/00 ,  G03G21/14 ,  G06F1/28 ,  G06F11/16 ,  G06F13/28 ,  G06F13/00

    CPC classification number: G06F13/285 ,  G06F1/28

    Abstract: A non-volatile storage module as utilized in a controller for directing a plurality of control registers of a host machine. The controller includes a central processor that is communicatively coupled through a system bus having control data, and address lines to the module and host machine. The non-volatile storage module includes a data memory operative to interface with the system bus for storing data, and for input-output of the data therefrom through the system bus upon command of the central processor. In addition, the module further includes a power storage unit coupled to the data memory for distributing a plurality of power signals from the host machine through a plurality of critical and non-critical power lines to the data memory for providing a power source that may be utilized therein for a power down condition and for sensing a power down condition on the critical power line from the power storage unit for the switching thereof to the data memory. The module also includes an apparatus that is operative upon indication of a power down condition from the host machine for generating an enabling signal to the data memory while a current address signal on the system bus is being received by the data memory.

    Abstract translation: 一种在控制器中使用的用于引导主机的多个控制寄存器的非易失性存储模块。 控制器包括通过具有控制数据的系统总线通信耦合的中央处理器，以及到模块和主机的地址线。 非易失性存储模块包括操作用于与系统总线接口以存储数据的数据存储器，以及根据中央处理器的命令通过系统总线从其输入输出数据。 另外，模块还包括耦合到数据存储器的电力存储单元，用于通过多个关键和非关键电力线将多个功率信号从主机分配到数据存储器，以提供可以是 在其中用于断电状态并且用于感测来自蓄电单元的关键电力线上的断电状态以将其切换到数据存储器。 该模块还包括一种在主机上指示掉电状态的装置，用于在数据存储器正在接收系统总线上的当前地址信号时向数据存储器产生使能信号。

    METHOD AND APPARATUS FOR SANITIZING WATER DISPENSED FROM A WATER DISPENSER HAVING A RESERVOIR
    26.
    发明申请
    METHOD AND APPARATUS FOR SANITIZING WATER DISPENSED FROM A WATER DISPENSER HAVING A RESERVOIR 有权
    从具有储层的水分配器中分配水的方法和装置

    公开(公告)号：US20120055885A1

    公开(公告)日：2012-03-08

    申请号：US13221448

    申请日：2011-08-30

    Applicant: Kenneth A. Davis ,  James Jackson Shelton

    Inventor： Kenneth A. Davis ,  James Jackson Shelton

    IPC: C02F1/78

    CPC classification number: C02F1/50 ,  B67D3/0035 ,  B67D3/0038 ,  B67D2210/00002 ,  B67D2210/00013 ,  C02F1/78 ,  C02F2201/78 ,  Y10S261/42

    Abstract: A method and apparatus of sanitizing drinking water to be dispensed from a water dispenser having a reservoir includes the steps of providing the ozone gas generator that generates an ozone gas stream, transmitting the ozone gas stream from the generator to the water dispenser reservoir, mechanically breaking up the ozone gas stream inside the reservoir to produce ozone gas bubbles, and using the ozone gas bubbles to disinfect water in the reservoir. The ozone gas stream can be mechanically broken up using a pump such as, for example, an impeller type pump.

    Abstract translation: 从具有储存器的饮水机中分配饮用水的方法和装置包括以下步骤：提供产生臭氧气流的臭氧气体发生器，将来自发生器的臭氧气体流传递到水分配器储存器，机械破裂 使储存器内的臭氧气流产生臭氧气泡，并利用臭氧气泡对储层中的水进行消毒。 可以使用诸如叶轮式泵的泵机械地分解臭氧气体流。

    Intrinsically fluorescent, self-multimerizing MHC fusion proteins and complexes thereof
    28.
    发明授权
    Intrinsically fluorescent, self-multimerizing MHC fusion proteins and complexes thereof 有权
    本质荧光，自身多聚化MHC融合蛋白及其复合物

    公开(公告)号：US07202349B2

    公开(公告)日：2007-04-10

    申请号：US10045949

    申请日：2002-01-11

    Applicant: Kenneth A. Davis ,  Bing-Yuan Wei

    Inventor： Kenneth A. Davis ,  Bing-Yuan Wei

    IPC: C07K14/74 ,  G01N33/53 ,  G01N33/532 ,  C12N5/10

    CPC classification number: C07K14/70539 ,  C07K14/43595 ,  C07K19/00 ,  C07K2319/00 ,  Y10S435/975

    Abstract: Presented are intrinsically fluorescent, self-multimerizing MHC fusion proteins, and complexes assembled therefrom that are capable of detectably labeling antigen-specific T lymphocytes. Also presented are methods for labeling antigen-specific T lymphocytes with the intrinsically fluorescent complexes of the present invention, and methods, particularly flow cytometric methods, for detecting, enumerating, enriching, and depleting antigen specific T lymphocytes so labeled.

    Abstract translation: 本发明提供了本发明的荧光，自体多聚化MHC融合蛋白及其组装的复合体，其能够可检测地标记抗原特异性T淋巴细胞。 还提出了用本发明的本征荧光复合物标记抗原特异性T淋巴细胞的方法，以及用于检测，计数，富集和消耗如此标记的抗原特异性T淋巴细胞的方法，特别是流式细胞术方法。

    Method and apparatus for disinfecting a refrigerated water cooler reservoir
    29.
    发明授权
    Method and apparatus for disinfecting a refrigerated water cooler reservoir 有权
    用于消毒冷藏水冷却器贮存器的方法和装置

    公开(公告)号：US07175054B2

    公开(公告)日：2007-02-13

    申请号：US09996328

    申请日：2001-11-28

    Applicant: Kenneth A. Davis ,  James J. Shelton

    Inventor： Kenneth A. Davis ,  James J. Shelton

    IPC: B67D5/58

    CPC classification number: C02F9/005 ,  B67D2210/00013 ,  B67D2210/00023 ,  C02F1/685 ,  C02F1/78 ,  C02F2201/782 ,  C02F2209/005 ,  C02F2209/40

    Abstract: A method and apparatus for providing sanitized water in a cabinet and spigot type bottled water dispenser features an ozone generating system to generate ozone for sanitizing the water. Ozone is generated and collected within an ozone generator housing. A blower transmits air to the ozone generator housing. The air carries the ozone that is generated through a flow line to an air diffuser that is positioned upstream of the spigot (or spigots) used to dispense water. In one embodiment, a valve that is activated on the spigot to dispense water also activates the blower and ozone generator. In other embodiments, a flow sensor activates the ozone generator and blower. Various spigot and flow sensor arrangements are disclosed as a part of the overall apparatus and method.

    Abstract translation: 一种用于在橱柜和套管式瓶装饮水机中提供消毒水的方法和装置，其特征在于产生臭氧的臭氧发生系统以产生消毒水的臭氧。 臭氧产生并收集在臭氧发生器壳体内。 鼓风机将空气传送到臭氧发生器壳体。 空气将通过流动管线产生的臭氧携带到位于用于分配水的插口（或插口）上游的空气扩散器。 在一个实施例中，在套管上启动以分配水的阀也激活鼓风机和臭氧发生器。 在其他实施例中，流量传感器激活臭氧发生器和鼓风机。 公开了各种插口和流量传感器装置作为整体装置和方法的一部分。

    Method and apparatus for disinfecting a water cooler reservoir
    30.
    发明授权
    Method and apparatus for disinfecting a water cooler reservoir 有权

    公开(公告)号：US06532760B2

    公开(公告)日：2003-03-18

    申请号：US09954849

    申请日：2001-09-18

    Applicant: Kenneth A. Davis

    Inventor： Kenneth A. Davis

    IPC: B67D562

    CPC classification number: C02F9/005 ,  B67D3/0009 ,  B67D3/0035 ,  B67D2210/00013 ,  B67D2210/00023 ,  C02F1/008 ,  C02F1/78 ,  C02F2201/782

    Abstract: A method and apparatus for providing sanitized water in a bottled water dispenser uses a refrigeration system to cool the water and an ozone generating system to generate ozone for sanitizing the water. Ozone is generated and collected within an ozone generator housing. A blower transmits air to the housing, the air carrying the ozone through a flow line to an air diffuser that is positioned inside the reservoir of the water dispenser. A time deactivates the refrigeration system and at about the same time activates the ozone generator and the blower. The blower continues to pump air for a selected time period after the ozone generator is shut down, the water in the reservoir having been sanitized. This action dispenses any ozone odor. The pump then shuts off and the refrigeration system resumes operation of cooling the water in the reservoir.

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