Abstract:
Verfahren zur Herstellung von Alkylketendimeren durch Umsetzung von Carbonsäurechloriden mit tertiären Aminen im Molverhältnis 1 : 1 bis 1 : 1,6 bei Temperaturen von 65 bis 150 °C und einer Verweilzeit von 1 bis 30 min in Abwesenheit von Lösemitteln unter intensivem Mischen und Abtrennung der Alkylketendimeren.
Abstract:
Die vorliegende Erfindung betrifft ein dreidimensional verformtes Folienelement herstellbar durch isostatische Hochdruckverformung, wobei die dreidimensionale Verformung des Folienelements derart ausgestaltet ist, dass in das ebene Folienelement eine oder mehrere Vertiefungen und/oder Erhebungen eingeformt sind, ein Verfahren zur Herstellung des erfindungsgemäßen dreidimensional verformten Folienelements und die Verwendung des erf indungsgemäßen dreidimensional verformten Folien- elements zur Ausbildung von mobilen oder stationären Kennzeichnungsschildern.
Abstract:
An in-space servicing vehicle system (10) includes a servicing spacecraft (22) and a propellant module (24). The servicing spacecraft (22) includes a client servicing system (136) for servicing a client spacecraft (16) in space. The servicing spacecraft (22) also includes navigation avionics (108) for independent flight operation and a servicing propellant tank (170). The propellant module (24) moves the servicing module (22) from an upper stage drop off location to a proximate location (21) of the client spacecraft (16). The propellant module (24) includes a propellant module tank (172) that has propellant for multiple spacecraft-servicing missions. The servicing spacecraft (22) separates from the propellant module (24) and operatively approaches and docks with the client spacecraft (16). The navigation avionics (108) may serve as avionics for both the servicing spacecraft (22) and the propellant module (24). The servicing spacecraft (22) may also have a universal docking adaptor (70) that couples to and converts the client spacecraft (16) from non-cooperative to cooperative.
Abstract:
The invention relates to the use of polymers comprising thermoplastic polymers as filtration aids and/or stabilising agent for the filtration or stabilisation of aqueous liquids.
Abstract:
The present invention relates to a process for producing monolithic tablets. The method employs a melt-processed composition containing at least on active agent and at least one thermoplastic binder. The invention further relates to a method for cutting and deflashing a belt of pre-shaped bodies of a melt-processed composition, wherein the pre-shaped bodies are interconnected by flash.
Abstract:
Die Erfindung bezieht sich auf ein Verfahren und eine Vorrichtung zur thermischen Behandlung von in Pulver- oder Granulatform vorliegenden Feststoffen mit Gasströmen (7, 16, 22, 23, 24) mittels eines um seine Rotationsachse (1) bewegten Körpers (2). Bei diesem Verfahren werden sukzessive die nachfolgenden Verfahrensschritte durchlaufen: Zunächst wird das in Segmenten (3) des bewegten Körpers (2) aufgenommene Schüttgut durch Beaufschlagung mit Wasserdampf (22) erwärmt. Danach wird das erwärmte Schüttgut in einem oder mehreren Folgeschritten einer Luftzufuhr (23) und/oder einer Inertgaszufuhr (24) ausgesetzt. Schliesslich erfolgt die Entnahme (17) des getrockneten und/oder inertisierten Schüttgutes aus den Segmenten (3) des um seine Rotationsachse (1) bewegten Körpers (2).
Abstract:
A curcuminoid formulation, comprising a melt-processed solid dispersion product comprising one or more curcuminoids, a nutritionally acceptable thermoplastic polymer, and a phosphatide; providing an improved oral bioavailability compared to non-formulated crystalline curcuminoid. A method for producing said formulation. A nutritional product fortified with said formulation. Said formulation for use in the treatment or prophylaxis of cancer, conditions involving an inflammatory reaction, neurological disorders, cardiovascular disease, pulmonary disease, the formation of cholesterol gallstones, and parasitic infestation.
Abstract:
A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95 % by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight- average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.
Abstract:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
Abstract:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.