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公开(公告)号：WO2006081000A3
公开(公告)日：2006-09-28
申请号：PCT/US2005045321
申请日：2005-12-15
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
Inventor： KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
IPC: C08G65/326 , C08G65/334 , C08L71/02
CPC classification number: C08G65/334 , A61K8/90 , A61K9/146 , A61K47/34 , A61Q19/00 , C08G65/326 , C08L71/02
Abstract: The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat amyriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, pulmonary, and nasal.
Abstract translation: 本发明涉及新化合物，制备方法和使用方法。 本发明还涉及具有一种或多种与其表面相关的本发明化合物的固体药物/活性剂颗粒。 本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。 该化合物具有两性质量，优选表面活性。 这些化合物优选用作表面活性剂以涂覆和稳定颗粒在连续液体介质中的分散体。 这些表面活性剂可以用于稳定用于制药，医疗，化妆品或农业用途的悬浮液，乳剂或脂质体制剂。 可以通过多种方法制备并且优选包含药剂的颗粒。 本发明的药物组合物可用于治疗异常的病症，并且可以通过许多途径施用，包括静脉内，肌肉内，皮下，鞘内，硬膜下，阴道内，脑内，肠内，局部，口服，口腔，直肠，肺和 鼻。
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公开(公告)号：WO2005077337A3
公开(公告)日：2006-03-23
申请号：PCT/US2005002471
申请日：2005-01-26
Applicant: BAXTER INT , KIPP JAMES E , DOTY MARK , REBBECK CHRISTINE L
Inventor： KIPP JAMES E , DOTY MARK , REBBECK CHRISTINE L
CPC classification number: A61K9/1075 , A61K9/113 , A61K31/557
Abstract: The present invention relates to a dispersion of an active agent, which includes a multiphase system of an organic phase and an aqueous phase. The agent, preferably poorly water soluble, possesses surface active properties and itself serves as a dispersantor a stabilizer for the dispersion. The dispersion is suitable for pharmaceutical, veterinary, cosmetic, and agricultural applications, and is suitable for in vivo delivery, particularly by parenteral routes.
Abstract translation: 本发明涉及活性剂的分散体，其包括有机相和水相的多相体系。 优选水溶性差的试剂具有表面活性，并且其本身用作分散剂或分散体的稳定剂。 该分散体适用于药物，兽医，化妆品和农业应用，并且适合于体内递送，特别是通过肠胃外途径。
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公开(公告)号：WO2005077337A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/002471
申请日：2005-01-26
Applicant: BAXTER INTERNATIONAL INC. , KIPP, James, E. , DOTY, Mark , REBBECK, Christine, L.
Inventor： KIPP, James, E. , DOTY, Mark , REBBECK, Christine, L.
IPC: A61K9/107
CPC classification number: A61K9/1075 , A61K9/113 , A61K31/557
Abstract: The present invention relates to a dispersion of an active agent, which includes a multiphase system of an organic phase and an aqueous phase. The agent, preferably poorly water soluble, possesses surface active properties and itself serves as a dispersantor a stabilizer for the dispersion. The dispersion is suitable for pharmaceutical, veterinary, cosmetic, and agricultural applications, and is suitable for in vivo delivery, particularly by parenteral routes.
Abstract translation: 本发明涉及活性剂的分散体，其包括有机相和水相的多相体系。 优选水溶性差的试剂具有表面活性，并且其本身用作分散剂或分散体的稳定剂。 该分散体适用于药物，兽医，化妆品和农业应用，并且适合于体内递送，特别是通过肠胃外途径。
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