公开(公告)号：EP3017292A1

公开(公告)日：2016-05-11

申请号：EP14734498.0

申请日：2014-07-02

Applicant: Laser- und Medizin-Technologie GmbH Berlin

Inventor： HELFMANN, Jürgen ,  GERSONDE, Ingo ,  CAPPIUS, Hans-Joachim ,  LIEBOLD, Karsten ,  NETZ, Uwe

IPC: G01N21/31 ,  G01N21/59 ,  G01N21/03

CPC classification number: G01N21/31 ,  C12M23/26 ,  C12M23/28 ,  C12M41/46 ,  G01N21/03 ,  G01N21/59 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2201/062

Abstract: The invention relates to a non-destructive and non-invasive method for determining the concentration or other parameters of constituent substances in fluids, which method is capable of minimizing the optical interfering influences, which are unknown but constant during the individual measurement, of the vessel wall on the measurement result or the evaluation, in that measurements are carried out with different through-radiation path lengths and quotient calculations eliminate the influences of the vessel wall. Wide-area illumination and detection ensure that non-linearities occurring during said measurements do not interfere with the accuracies of the determination.

公开(公告)号：EP3114443A2

公开(公告)日：2017-01-11

申请号：EP15717427.7

申请日：2015-03-06

Applicant: Laser- und Medizin-Technologie GmbH Berlin

Inventor： HELFMANN, Jürgen ,  CAPPIUS, Hans-Joachim

IPC: G01J3/02

CPC classification number: G01N21/4785 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  G01J3/0218 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/0297 ,  G01J3/42 ,  G01J2003/104 ,  G01N21/33 ,  G01N21/3554 ,  G01N21/49 ,  G01N2021/3144 ,  G01N2021/4709 ,  G01N2021/4733 ,  G01N2201/1211

Abstract: The invention relates to an optical sensor device which measures in a spatially resolving manner. In order to devise such a sensor device with which a contacting measurement of the article to be measured can be carried out and which can be mass-produced, the sensor device is designed such that a transfer of the calibration onto individual sensor devices is possible with high accuracy. According to certain embodiments of the design of the sensor device and of the evaluation methods, interferences with the measurement of the amount of the target substance are minimized.

Abstract translation: 公开了一种以空间分辨方式测量的光学传感器装置。 为了设计这样的传感器装置，通过该传感器装置可以进行待测量物品的接触测量并且可以进行大量生产，传感器装置被设计成使得校准转移到各个传感器装置上是可能的， 高准确率。 根据传感器装置的设计和评估方法的某些实施例，与靶物质量的测量的干扰被最小化

公开(公告)号：EP1252542A1

公开(公告)日：2002-10-30

申请号：EP00901122.2

申请日：2000-01-20

Applicant: Laser- und Medizin-Technologie GmbH Berlin

Inventor： BEUTHAN, Jürgen ,  EBERLE, Hans-Georg ,  HELFMANN, Jürgen ,  MÜLLER, Gerhard

IPC: G02B21/00

CPC classification number: G01N21/251 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/253

Abstract: The invention relates to a device and a method for the assessment of a great number of cells, in a measurement and evaluation process, under near-field optical conditions, with regard to the reaction state of molecular reactants. A sample stage is characterised, in that light sources with various aperture diameters, in the nano- or micro-range, are mounted therein. The 2D nano light source array is formed from a number of near-field light sources, arranged in a contiguous raster and consecutively, or simultaneously stimulated. A semiconductor material is used as support material.

公开(公告)号：EP2596900A1

公开(公告)日：2013-05-29

申请号：EP12194648.7

申请日：2012-11-28

Applicant: Laser- und Medizin-Technologie GmbH Berlin

Inventor： Ashkenasi, David, Dr. ,  Müller, Norbert, Dipl.-Ing.

IPC: B23K26/06

CPC classification number: B23K26/0604 ,  B23K26/0608 ,  B23K26/0613 ,  B23K26/0624

Abstract: Die Erfindung betrifft eine Vorrichtung zur Materialbearbeitung und ein zugehöriges Verfahren. Dabei werden ein Anregungslaserstrahl (310) und ein Bearbeitungslaserstrahl (210) auf ein transparentes Werkstück (120) gerichtet, wobei erst bei Überlappung der beiden Laserstrahlen eine bleibende Materialbearbeitung erfolgt. Die Vorrichtung (100) zur Materialbearbeitung, insbesondere zum Materialabtrag, Verschweißen oder zum Ändern von Materialeigenschaften transparenter Werkstücke (120) weist einen Bearbeitungslaser (200) auf, welcher im Betrieb einen Bearbeitungslaserstrahl (210) emittiert, wobei der Bearbeitungslaser mit einer ersten Positioniervorrichtung (140 150) verbunden ist, welche den Bearbeitungslaserstrahl im Betrieb mittels geeigneter Optiken (220, 230) relativ zu einem Werkstück (120) positioniert. Die Vorrichtung (100) zur Materialbearbeitung weist ferner einen Anregungslaser (300) auf, welcher im Betrieb einen Anregungslaserstrahl (310) emittiert, der alleine keine bleibende Materialveränderung bewirkt, wobei der Anregungslaser (300) mit einer zweiten Positioniervorrichtung (141, 151) verbunden ist, welche den Anregungslaserstrahl im Betrieb mittels geeigneter Optiken (320, 330) relativ zu einem Werkstück und dem Bearbeitungslaserstrahl in diesem Werkstück positioniert. Die erste Positioniervorrichtung (140, 150) und die zweite Positioniervorrichtung (141, 151) sind so ausgebildet, dass der Anregungslaserstrahl (310) im Betrieb ein definiertes Anregungsvolumen (340) induziert, in dem eine Materialbearbeitung des Werkstücks (120) mit dem Bearbeitungslaserstrahl (210) erfolgt.

Abstract translation: 该装置包括：处理激光器（200），其在操作期间发射处理激光束（210），其中处理激光器连接到位于处理激光束的第一定位装置（140,150） 通过合适的光学器件（220,230）相对于工件的操作; 并且在操作期间发射激发光束的激发激光器（300）不会引起永久性材料变化，并且与激发激光束相对于工件定位的第二定位装置连接。 该装置包括：处理激光器（200），其在操作期间发射处理激光束（210），其中处理激光器连接到位于处理激光束的第一定位装置（140,150） 通过合适的光学器件（220,230）相对于工件的操作; 并且在操作期间发射激发光束的激发激光器（300）不会引起永久性材料变化，并且连接到与激发激光束相对于工件定位的第二定位装置以及与处理激光器 在光学器件运行期间在工件中产生光束。 第一和第二定位装置形成为使得激光激光束在其中用处理激光束进行工件的材料处理的操作期间引起限定的激发体积。 处理激光器是脉冲的，并且具有300nm和10μm的波长和100ns至1μs的脉冲持续时间。 激发激光器是脉冲的，脉冲持续时间为0.1-10ps，最大脉冲能量为1mJ，峰值功率为100kW，重复频率为0.1-1MHz。 该装置还包括控制器，其中定位装置被控制，使得激光束相对于激发体积的重叠设置在工件上或工件中。 控制器：配置为与工件同步执行重叠和励磁量; 并且还被配置为沿着相对于工件的预定路径来控制重叠和激励体积。 包括用于焊接或改变透明工件的材料性质的方法的独立权利要求。

公开(公告)号：EP1180055A2

公开(公告)日：2002-02-20

申请号：EP00958278.4

申请日：2000-05-12

Applicant: Laser- und Medizin-Technologie GmbH Berlin

Inventor： MÜLLER, Gerhard ,  REGULLA, Dieter

IPC: A61N5/10

CPC classification number: A61N5/1027 ,  A61N5/1002 ,  A61N2005/1098

Abstract: The invention relates to a device (100) for carrying out radiotherapy on a limited target area of tissue (T), comprising a source of radiation (122), which is configured to emit ionizing radiation, and a deposit (112), which is located inside the target area of tissue (T) or adjacent thereto and which is configured for backscattering radiation. According to the invention, said deposit (112) contains a metal complex compound in a liquid solution or in an emulsion.

公开(公告)号：EP1087709A1

公开(公告)日：2001-04-04

申请号：EP99929232.9

申请日：1999-06-16

Applicant: Laser-und Medizin-Technologie GmbH, Berlin

Inventor： MÜLLER, Gerhard ,  HARTMANN, Christian ,  DESINGER, Kai ,  SCHRÜNDER, Stephan

IPC: A61B17/32 ,  A61F9/007

CPC classification number: A61B17/320068 ,  A61F9/00745

Abstract: The invention relates to a surgical instrument (10) for concurrently or intermittently emitting laser light and ultrasound which comprises a housing (12) and an acousto-optic waveguide (38). Said waveguide is arranged in the housing and exits through a distally configured opening of the housing (12). Laser light can be injected at the proximal end thereof. The instrument also comprises an ultrasonic transducer (18) which is situated inside the housing (12) and which is provided for generating an ultrasonic wave that propagates along the waveguide (38). The instrument is provided with an oscillating body (28 to 36) which is connected to the ultrasonic transducer (18) in a proximal manner, which is connected to the waveguide (38) in a distal manner, and which is provided for injecting the ultrasonic wave into the waveguide while matching the lateral expansion of the ultrasonic wave to the cross-section of the waveguide (38) and while amplifying the amplitude thereof. According to the invention, the oscillating body (28 to 36) has a boring which is at least configured on the distal end thereof and which is coaxial in relation to the acousto-optic waveguide (38). The acousto-optic waveguide (38) is fixed on the wall of said boring.

公开(公告)号：EP1018956A1

公开(公告)日：2000-07-19

申请号：EP98948775.6

申请日：1998-08-07

Applicant: Laser-und Medizin-Technologie GmbH, Berlin

Inventor： MÜLLER, Gerhard ,  DESINGER, Kai ,  SCHALDACH, Brita

IPC: A61B17/36 ,  A61B17/22 ,  A61B17/32

CPC classification number: A61B17/320068 ,  A61B18/20 ,  A61B18/22 ,  A61B2017/00247 ,  A61B2018/00392

Abstract: The invention relates to a laser therapy assembly (1) for the revascularization of muscular tissues (t), especially cardiac muscular tissues. Said assembly comprises a laser source (2) and an optical coupling unit (9, 11) for transmitting the laser beam (L) into the muscular muscle. It further comprises an ultrasound generator (6) connected to the optical coupling unit for a transfer of heat to the muscular tissue, which can be regulated independently from the laser beam with the purpose of producing a thermal effect that can be separately adjusted, especially a marginal thermal necrosis, in a channel generated in the muscular tissue.