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    COMPOSITION, PREPARATION, AND USE OF CHITOSAN POWER FOR BIOMEDICAL APPLICATIONS
    26.
    发明申请
    COMPOSITION, PREPARATION, AND USE OF CHITOSAN POWER FOR BIOMEDICAL APPLICATIONS 审中-公开
    组合物，制备和使用生物医学应用的CHITOSAN功率

    公开(公告)号：WO2016049203A1

    公开(公告)日：2016-03-31

    申请号：PCT/US2015/051748

    申请日：2015-09-23

    Applicant: LOMA LINDA UNIVERSITY ,  LOMA LINDA UNIVERSITY MEDICAL CENTER ,  NORTH CAROLINA STATE UNIVERSITY

    Inventor： KIRSCH, Wolff, M. ,  HUDSON, Samuel, M. ,  CROFTON, Andrew

    IPC: A61K9/70 ,  A61B17/06 ,  A61B17/00

    CPC classification number: A61K31/722 ,  A61K9/70 ,  A61L2/081 ,  A61L2/14

    Abstract: A powder chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A powder chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ- irradiation, treating under a nitrogen plasma, or both.

    Abstract translation: 基于壳聚糖的粉末材料可用于生物医学应用。 壳聚糖已经在氮气田中通过施加能量来电离壳聚糖材料中和周围的氮而被处理。 可以使用单次或多次这样的治疗。 例如，可以使用γ-照射在氮气下照射壳聚糖材料，在氮等离子体下进行处理，或者两者。 粉末壳聚糖材料可以通过表面改性处理容易地进行处理，例如使用γ-照射在氮气下照射，在氮等离子体下处理或两者。

    COMPOSITION, PREPARATION, AND USE OF CHITOSAN HEMOSTAT FOR LAPAROSCOPIC PARTIAL NEPHRECTOMY
    27.
    发明申请
    COMPOSITION, PREPARATION, AND USE OF CHITOSAN HEMOSTAT FOR LAPAROSCOPIC PARTIAL NEPHRECTOMY 审中-公开
    壳聚糖血栓形成剂在腹腔镜部分肾切除术中的组成，制备及应用

    公开(公告)号：WO2015195580A9

    公开(公告)日：2015-12-23

    申请号：PCT/US2015/035885

    申请日：2015-06-15

    Applicant: LOMA LINDA UNIVERSITY ,  LOMA LINDA UNIVERSITY MEDICAL CENTER ,  NORTH CAROLINA STATE UNIVERSITY

    Inventor： KIRSCH, Wolff, M. ,  HUDSON, Samuel, M. ,  CROFTON, Andrew

    IPC: A61K31/722

    Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both. A treated thin chitosan material can be utilized to control bleeding and assist in treatment and healing during a surgical procedure, including laparoscopic partial nephrectomy.

    Abstract translation: 基于壳聚糖的薄材料可用于生物医学应用。 壳聚糖已经通过在壳聚糖材料中和周围施加能量以电离氮气而在氮场中进行处理。 可以采用单个或多个这样的处理。 例如，壳聚糖材料可以在使用γ-照射的氮气下，在氮气等离子体下处理或两者照射。 薄壳聚糖材料可容易地通过表面改性处理来处理，例如使用γ-照射在氮下照射，在氮等离子体下处理或两者处理。 经处理的薄壳聚糖材料可用于控制出血并在包括腹腔镜部分肾切除术在内的手术过程中协助治疗和愈合。

    SNAKE VENOM FOR USE IN THE TREATMENT PRIOR TO A SURGICAL PROCEDURE IN THE BRAN
    29.
    发明申请
    SNAKE VENOM FOR USE IN THE TREATMENT PRIOR TO A SURGICAL PROCEDURE IN THE BRAN 审中-公开
    SNAKE VENOM在BRAN手术过程中的治疗中使用

    公开(公告)号：WO2015184380A1

    公开(公告)日：2015-12-03

    申请号：PCT/US2015/033365

    申请日：2015-05-29

    Applicant: LOMA LINDA UNIVERSITY ,  LOMA LINDA UNIVERSITY MEDICAL CENTER

    Inventor： ZHANG, John, H. ,  KIM, Cherine ,  SHERCHAN, Prativa ,  KRAFFT, Paul ,  MCBRIDE, Devin ,  LEKIC, Tim

    IPC: A61K35/583 ,  A61P41/00

    CPC classification number: A61K35/583 ,  A61K38/17

    Abstract: A treatment for reducing brain or other injury that can be used before, during, or after a surgical treatment or other injury to the brain to decrease or prevent subsequent damage. Injury to the brain during surgery or from other trauma can create elevations in brain edema and blood-brain barrier disruption thereby decreasing neurological recovery and patient outcomes. Treatment of the brain with venom, including snake venom, prior to or after injury can reduce the bleeding, swelling, and/or inflammation that results from the trauma. These pre-conditioning and/or rapid-conditioning treatments of the brain with venom can reduce brain edema and blood-brain barrier disruption and improve patient outcomes.

    Abstract translation: 用于减少在脑外科手术治疗或其他损伤之前，期间或之后可能使用的脑部或其他损伤的治疗方法，以减少或防止随后的损伤。 在手术或其他创伤期间对大脑的损伤可能会导致脑水肿和血脑屏障破裂升高，从而减少神经恢复和患者结局。 在损伤之前或之后用毒液（包括蛇毒）治疗脑可以减少由创伤引起的出血，肿胀和/或炎症。 这些用毒液预处理和/或快速处理大脑可以减少脑水肿和血脑屏障破坏，并改善患者的预后。

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