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    NASAL FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID
    22.
    发明申请
    NASAL FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID 审中-公开
    含有硫代叶酸环孢菌素和角质疏螺旋藻的NASAL配方

    公开(公告)号：WO2008005802A2

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/072387

    申请日：2007-06-28

    Applicant: CYDEX, INC. ,  PIPKIN, James, D. ,  ZIMMERER, Rupert, O.

    Inventor： PIPKIN, James, D. ,  ZIMMERER, Rupert, O.

    IPC: A61K31/724 ,  A61K31/573

    CPC classification number: A61K47/6851 ,  A61K9/0078 ,  A61K31/573 ,  A61K31/58 ,  A61K31/724 ,  A61K45/06 ,  A61K47/40 ,  A61K47/61 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0015 ,  C08L5/16 ,  A61K2300/00

    Abstract: A formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for nasal administration to a subject with any known nasal administration device. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to- use solution, or concentrated composition. The formulation is employed in an improved system for administering corticosteroid intranasally. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation is provided.

    Abstract translation: 提供了含有SAE-CD和皮质类固醇的制剂。 该制剂适于用任何已知的鼻给药装置向受试者进行鼻腔给药。 制剂可以包含在试剂盒中。 制剂作为水溶液施用，然而，其可以作为干粉，即用溶液或浓缩组合物储存。 该制剂用于鼻内给予皮质类固醇的改进体系。 配方中的SAE-CD显着提高了布地奈德的化学稳定性。 提供了一种施用该制剂的方法。

    INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION
    23.
    发明申请
    INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION 审中-公开
    含有来自单体剂量悬浮液的硫酸环己酮和角质醇的吸入制剂

    公开(公告)号：WO2008005691A1

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/071748

    申请日：2007-06-21

    Applicant: CYDEX, INC. ,  ZIMMERER, Rupert, O. ,  PIPKIN, James, D. ,  THOMPSON, Diane, O. ,  MOSHER, Gerold, L.

    Inventor： ZIMMERER, Rupert, O. ,  PIPKIN, James, D. ,  THOMPSON, Diane, O. ,  MOSHER, Gerold, L.

    IPC: A61K9/12 ,  A61K9/14 ,  A61K31/57 ,  A61K31/16

    CPC classification number: A61K47/40 ,  A61K9/0078 ,  A61K31/137 ,  A61K31/47

    Abstract: An inhalable unit dose liquid formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of corticosteroid, such as budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation is prepared by mixing SAE-CD, in solid or liquid (dissolved) form, with an inhalable suspension-based unit dose formulation.

    Abstract translation: 提供含有SAE-CD和皮质类固醇的可吸入单位剂量液体制剂。 该制剂适于用任何已知的喷雾器通过雾化给予受试者。 制剂可以包含在试剂盒中。 制剂以水溶液或浓缩组合物的形式给药。 该制剂用于通过吸入施用皮质类固醇的改进的雾化系统。 配方中的SAE-CD显着提高了皮质类固醇（如布地奈德）的化学稳定性。 提供了通过吸入给药该制剂的方法。 制剂也可以通过常规的鼻输送装置来施用。 通过将固体或液体（溶解）形式的SAE-CD与可吸入悬浮液的单位剂量制剂混合来制备制剂。

    DPI FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN
    25.
    发明申请
    DPI FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN 审中-公开
    含有硫代环戊二烯的DPI配方

    公开(公告)号：WO2005104712A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2005014010

    申请日：2005-04-22

    Applicant: CYDEX INC ,  PIPKIN JAMES D ,  ZIMMERER RUPERT O ,  HICKEY ANTHONY J ,  THOMPSON DIANE O ,  SMYTH HUGH D C

    Inventor： PIPKIN JAMES D ,  ZIMMERER RUPERT O ,  HICKEY ANTHONY J ,  THOMPSON DIANE O ,  SMYTH HUGH D C

    IPC: A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K47/40 ,  C08B37/16

    CPC classification number: A61K47/40 ,  A61K9/0075 ,  Y10T428/2982

    Abstract: An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.

    Abstract translation: 提供含有SAE-CD和活性剂的可吸入干粉配方。 该制剂适用于DPI的给药。 SAE-CD作为载体而不是吸收增强剂。 SAE-CD的平均粒径足够大以排除（大部分）肺沉积。 从DPI装置释放后，含有SAE-CD的颗粒从颊腔或咽喉中的含活性剂颗粒分离，之后含活性剂的颗粒继续深入呼吸道。 SAE-CD的物理化学和形态学特性易于修饰，可以优化活性剂和载体的相互作用。 当使用SAE-CD作为载体时，具有正，中性或负静电电荷的药物可由DPI递送。

    A CONTROLLED RELEASE DRUG SUSPENSION DELIVERY DEVICE
    27.
    发明申请
    A CONTROLLED RELEASE DRUG SUSPENSION DELIVERY DEVICE 审中-公开
    控制释放药物悬挂递送装置

    公开(公告)号：WO1996019201A1

    公开(公告)日：1996-06-27

    申请号：PCT/US1995016530

    申请日：1995-12-18

    Applicant: MERCK & CO., INC. ,  RORK, Gerald, S. ,  PIPKIN, James, D.

    Inventor： MERCK & CO., INC.

    IPC: A61K09/24

    CPC classification number: A61K9/2072 ,  A61K9/2086

    Abstract: A device is disclosed for the controlled delivery of a beneficial agent, the device consisting of (i) a core comprising at least two layers, wherein at least one layer comprises a beneficial agent and a polymer which forms microscopic gel beads upon hydration and at least one layer which comprises a polymer which forms microscopic gel beads upon hydration; and (ii) an impermeable, insoluble coating which adheres to and surrounds the core and contains apertures which provide an area for the hydration and release of the microscopic gel beads.

    Abstract translation: 公开了用于受控输送有益试剂的装置，该装置由（i）包含至少两层的芯组成，其中至少一层包含有益试剂和在水合时形成微细凝胶珠的聚合物，并且至少 一层，其包含在水合时形成微观凝胶珠的聚合物; 和（ii）不渗透的不溶性涂层，其粘附并围绕芯并且包含提供用于微细凝胶珠的水合和释放的区域的孔。

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