CONCOMITANT MEDICINE CONTAINING α-2-δ-LIGAND
    21.
    发明专利
    CONCOMITANT MEDICINE CONTAINING α-2-δ-LIGAND 审中-公开
    含有α-2-δ-LIGAND的可持续药物

    公开(公告)号:JP2006241158A

    公开(公告)日:2006-09-14

    申请号:JP2006052759

    申请日:2006-02-28

    Abstract: PROBLEM TO BE SOLVED: To provide a medicinal composition for treatment of pains, particularly inflammatory pain, neuropathic pain, visceral pain and nociceptive pain and to provide a method for treating these pains. SOLUTION: The concomitant medicine comprises PDE7 (phosphodiesterase 7) inhibitor and an α-2-δ-ligand. In the concomitant medicine, the PDE7 inhibitor is selected from e.g. 5'-carboxypropoxy-8'-chloro-spiro[cyclohexane-1'-4'-(3',4'-dihydro)quinazolin]-2'(1'H)-one or selected from pharmaceutically acceptable salts thereof or solvates thereof. The medicinal composition comprises the concomitant medicine and a pharmaceutically acceptable vehicle. The α-2-δ-ligand is e.g. gabapentin. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 待解决的问题:提供治疗疼痛,特别是炎性疼痛,神经性疼痛,内脏痛和伤害性疼痛的药物组合物,并提供治疗这些疼痛的方法。 解决方案:伴随药物包含PDE7(磷酸二酯酶7)抑制剂和α-2-δ-配体。 在伴随药物中,PDE7抑制剂选自例如。 5'-羧基丙氧基-8'-氯 - 螺[环己烷-1'-4' - (3',4'-二氢)喹唑啉] -2'(1'H) - 酮或选自其药学上可接受的盐或溶剂合物 它们。 药物组合物包含并用药物和药学上可接受的载体。 α-2-δ-配体是例如。 加巴喷丁。 版权所有(C)2006,JPO&NCIPI

    Dispensing device
    24.
    发明专利
    Dispensing device 有权
    分配设备

    公开(公告)号:JP2014168699A

    公开(公告)日:2014-09-18

    申请号:JP2014087001

    申请日:2014-04-21

    Abstract: PROBLEM TO BE SOLVED: To provide a dispensing device, particularly a dispensing device for dispensing individual doses of powder from respective pockets of a carrier.SOLUTION: A device is provided to dispense individual doses of powder from respective pockets of a pair of carriers 12, the device comprising: a support 30 for two disc-shaped carriers, each disc-shaped carrier having at least one substantially planar first side surface having an annular array of cavities in which respective pockets are formed and a respective first lidding sheet sealed to the first side surface for enclosing the cavities, in which the support 30 is for rotatably supporting the carriers about a substantially common axis; a mouthpiece through which to inhale an airstream carrying powder from the carriers 12; a dispensing mechanism for releasing into the airstream the powder of a respective pocket of a supported carrier; and an indexing mechanism for rotating the carrier relative to the dispensing mechanism so as to enable powder to be released from different pockets.

    Abstract translation: 要解决的问题:提供一种分配装置,特别是用于从载体的相应凹穴分配单独剂量的粉末的分配装置。解决方案:提供一种装置,用于从一对载体12的相应凹穴分配单个剂量的粉末, 该装置包括:用于两个盘状载体的支撑件30,每个盘状载体具有至少一个基本上平面的第一侧表面,其具有环形阵列的空腔,其中形成有相应的凹穴;以及相应的第一封盖片, 侧表面用于封闭空腔,其中支撑件30用于围绕基本共同的轴线可旋转地支撑托架; 吸嘴,其通过其从载体12吸入携带粉末的气流; 分配机构,用于将支撑载体的相应袋的粉末释放到气流中; 以及用于使托架相对于分配机构旋转的分度机构,以使得粉末能够从不同的口袋释放。

    Device for dispensing a plurality of unitary doses of dry powder, and inhaler comprising such device
    26.
    发明专利
    Device for dispensing a plurality of unitary doses of dry powder, and inhaler comprising such device 有权
    用于分配大量的干粉剂量的装置,以及包含这些装置的吸入装置

    公开(公告)号:JP2011147774A

    公开(公告)日:2011-08-04

    申请号:JP2011004626

    申请日:2011-01-13

    Abstract: PROBLEM TO BE SOLVED: To provide a device for dispensing a plurality of unitary doses of dry powder.
    SOLUTION: The device comprises: a first support 25a and a second support 25b; an indexing mechanism adapted to move the first support 25a and second support 25b, the indexing mechanism and the supports being configured so that in a first dispensing state of the device, the first support 25a is in engagement with and the second support 25b is disengaged from the indexing mechanism, in a second dispensing state of the device, the second support 25b is in engagement with and the first support 25a is disengaged from the indexing mechanism; and a changeover mechanism adapted to cause the device to pass from the first dispensing state to the second dispensing state, to lock the second support 25b while the device is in the first dispensing state, and to lock the first support 25a while the device is in the second dispensing state.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题:提供一种用于分配多个单位剂量的干粉的装置。 解决方案:该装置包括:第一支撑件25a和第二支撑件25b; 适于移动第一支撑件25a和第二支撑件25b的分度机构,分度机构和支撑件构造成使得在装置的第一分配状态下,第一支撑件25a与第二支撑件25b脱离接合 所述分度机构在所述装置的第二分配状态下,所述第二支撑件25b与所述分度机构脱离接合,并且所述第一支撑件25a与所述分度机构脱离接合; 以及适于使装置从第一分配状态转移到第二分配状态的转换机构,以在装置处于第一分配状态时锁定第二支撑件25b,并且在装置处于该状态时锁定第一支撑件25a 第二分配状态。 版权所有(C)2011,JPO&INPIT

    Device for dispensing a plurality of unitary doses of dry powder, and inhaler comprising such device
    27.
    发明专利
    Device for dispensing a plurality of unitary doses of dry powder, and inhaler comprising such device 有权
    用于分配大量的干粉剂量的装置,以及包含这些装置的吸入装置

    公开(公告)号:JP2011147773A

    公开(公告)日:2011-08-04

    申请号:JP2011004621

    申请日:2011-01-13

    Abstract: PROBLEM TO BE SOLVED: To provide a device for dispensing a plurality of unitary doses (2) of dry powder. SOLUTION: The device comprises at least one support comprising conduits each defining a flow path for an airstream carrying one of the unitary dose (2), the support has a first member (26) and a second member (27) secured to one another so that a first conduit portion (29) of the first member faces a second conduit portion (43) of the second member to define one of the conduits, and a first separation portion (30) of the first member faces a second separation portion (45) of the second member, and the support comprises a plurality of barrier-forming elements (31, 46) each arranged between corresponding first separation portion (30) and a second separation portion (45) to prevent dry powder from passing from one of the conduits to one of the adjacent conduits. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题:提供一种用于分配多个单一剂量(2)干粉的装置。 解决方案:该装置包括至少一个支撑件,其包括导管,每个管道限定用于承载整体剂量(2)中的一个的气流的流动路径,所述支撑件具有第一构件(26)和第二构件(27) 使得第一构件的第一导管部分(29)面对第二构件的第二导管部分(43)以限定一个导管,并且第一构件的第一分隔部分(30)面向第二分离 第二构件的部分(45),并且支撑件包括多个阻挡形成元件(31,46),每个阻挡形成元件(31,46)均布置在相应的第一分隔部分(30)和第二分离部分(45)之间,以防止干粉从 一条相邻导管之一的导管。 版权所有(C)2011,JPO&INPIT

    Dispensing device
    28.
    发明专利
    Dispensing device 有权
    分配设备

    公开(公告)号:JP2010207616A

    公开(公告)日:2010-09-24

    申请号:JP2010121484

    申请日:2010-05-27

    Abstract: PROBLEM TO BE SOLVED: To provide a device for dispensing individual doses of powder from respective pockets of a carrier. SOLUTION: The device for dispensing individual doses of powder from respective pockets of a pair of carriers 12 includes: a support for two disk-shaped carriers 12, which the support rotatably supports the carriers 12 about a common axis, including at least one approximately plane first side surface having a ring-shaped array of the cavity in which respective disk-shaped carriers 12 are formed in respective pockets, and respective first lid sheet seals the first side surface to enclose the cavity; a mouthpiece through for inhaling an airstream for carrying powder from the carriers; and a dispensing mechanism for releasing the powder in the respective pockets of the supported carriers 12 into the airstream; and an indexing mechanism for rotating the carriers relative to the dispensing mechanism to enable powder to be released from different pockets. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题:提供一种用于从载体的相应凹穴分配单独剂量的粉末的装置。 解决方案:用于从一对载体12的相应凹穴分配单独剂量的粉末的装置包括:用于两个盘形载体12的支撑件,支撑件可旋转地支撑载体12围绕公共轴线,该载体12至少包括 一个大致平面的第一侧表面具有腔体的环形阵列,其中相应的圆盘形托架12形成在相应的凹穴中,并且各自的第一盖片密封第一侧表面以封闭空腔; 用于吸入用于从载体携带粉末的气流的吹口; 以及用于将支撑的载体12的各个袋中的粉末释放到气流中的分配机构; 以及用于使托架相对于分配机构旋转的分度机构,以使得粉末能够从不同的口袋释放。 版权所有(C)2010,JPO&INPIT

    New combination for treating hepatic fibrosis
    30.
    发明专利
    New combination for treating hepatic fibrosis 审中-公开
    治疗肝纤维化的新组合

    公开(公告)号:JP2007023030A

    公开(公告)日:2007-02-01

    申请号:JP2006188775

    申请日:2006-07-10

    CPC classification number: A61K45/06 A61K39/39541 A61K2300/00

    Abstract: PROBLEM TO BE SOLVED: To provide a combination of medicaments for treating hepatic fibrosis which is a signal of hepatic damage and also a potential contribution to hepatic failure mediated by liver's progressive cirrhosis, to provide uses of the combination, and to provide a pharmaceutical composition comprising the combination. SOLUTION: The new combination is provided, consisting of an anti-mucosal addressin cell adhesion molecule(MAdCAM) antibody and a protease inhibitor, preferably an anti-fibrosis agent such as a caspase inhibitor. The pharmaceutical composition comprising the above combination and the uses of the combination for treating hepatic fibrosis are also provided, respectively. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 待解决的问题:提供用于治疗肝纤维化的药物的组合,其是肝脏损伤的信号,以及由肝脏进行性肝硬化介导的肝功能衰竭的潜在贡献,以提供组合的用途,并提供一种 包含该组合的药物组合物。 解决方案:提供了由抗粘膜地址细胞粘附分子(MAdCAM)抗体和蛋白酶抑制剂,优选抗纤维化剂如半胱天冬酶抑制剂组成的新组合。 还分别提供了包含上述组合的药物组合物和用于治疗肝纤维化的组合的用途。 版权所有(C)2007,JPO&INPIT

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