公开(公告)号：WO1997048329A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010204

申请日：1997-06-19

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  RICHARDS-KORTUM, Rebecca ,  MAHADEVAN-JANSEN, Anita ,  RAMANUJAM, Nirmala ,  MITCHELL, Michele, Follen

Inventor： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

IPC: A61B05/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/4331 ,  A61B5/7264 ,  G01N21/65 ,  G01N2021/656

Abstract: Early diagnosis of cervical precancer is an important clinical goal. Optical spectroscopy has been suggested as a new technique to overcome limitations of current clinical practice. Herein, NIR Raman spectroscopy is applied to the diagnosis of cervical precancers. Using algorithms based on empirically selected peak intensities, ratios of peak intensities and a combination of Principal Component Analysis (PCA) for data reduction and Fisher Discriminant Analysis (FDA), normal tissues, inflammation and metaplasia were distinguishable from low grade and high grade precancers. The primary contributors to the tissue spectra appear to be collagen, nucleic acids, phospholipids and glucose 1-phosphate. These resuls suggest that near infrared Raman spectroscopy can be used effectively for cervical precancer diagnosis.

Abstract translation: 子宫颈癌的早期诊断是临床的重要目标。 光谱学被认为是克服当前临床实践的局限性的新技术。 在这里，NIR拉曼光谱法被应用于子宫颈预处理的诊断。 使用基于经验选择的峰值强度的算法，峰值强度的比率和用于数据降低的主成分分析（PCA）和Fisher判别分析（FDA），正常组织，炎症和化生的组合与低等级和高级别的预处理可以区分开。 组织光谱的主要贡献者似乎是胶原，核酸，磷脂和葡萄糖1-磷酸。 这些研究表明，近红外拉曼光谱可以有效地用于子宫颈癌前期诊断。