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公开(公告)号：WO2011041301A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050528
申请日：2010-09-28
Applicant: GENTEX CORPORATION , LEE, Ethan, J. , LEE, Daniel, B. , HENDRICKS, Michael, G. , ROTH, Mark., R. , MYERS, Craig, R. , POE, G., Bruce , BLAKER, David, A. , SCHAUDEL, Carsten , VAN VUUREN, Mark, A. , VANDERPLOEG, John, A.
Inventor： LEE, Ethan, J. , LEE, Daniel, B. , HENDRICKS, Michael, G. , ROTH, Mark., R. , MYERS, Craig, R. , POE, G., Bruce , BLAKER, David, A. , SCHAUDEL, Carsten , VAN VUUREN, Mark, A. , VANDERPLOEG, John, A.
CPC classification number: B60R1/12 , B60R2001/1253 , G02F1/13336 , G02F2201/44
Abstract: A multi-display vehicular rearview mirror system (2600) includes an electrochromic (EC) glass element (2603) and a plurality of liquid crystal displays (LCDs) ( 2605a, 2605b, 2605c) positioned behind EC element (2603). A plurality of light emitting diodes (LEDs) (2610a, 2610b, 2610c) are used for providing backlighting for each respective LCD of the plurality of LCDs such that the LCDs utilize a plurality of imaging devices (2717, 2719, 2721) for forming substantially a single image across the plurality of LCDs (2605a, 2605b, 2605c).
Abstract translation: 多显示器车辆后视镜系统（2600）包括电致变色（EC）玻璃元件（2603）和位于EC之后的多个液晶显示器（LCD）（2605a，2605b，2605c） 元素（2603）。 多个发光二极管（LED）（2610a，2610b，2610c）用于为多个LCD的每个相应的LCD提供背光，使得LCD利用多个成像装置（2717,2719,2721）基本上形成 横跨多个LCD（2605a，2605b，2605c）的单个图像。
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公开(公告)号：WO2010151625A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/039760
申请日：2010-06-24
Inventor： FRAZIER, Harold, N. , ROTH, Mark, B.
IPC: C12Q1/02
CPC classification number: G01N33/5085 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5044 , G01N33/66 , G01N2333/4353 , G01N2800/042
Abstract: What are described are methods of screening for or detecting defects in glucose metabolism in subjects, including screening for therapeutic molecules for treating diseases in glucose metabolism.
Abstract translation: 描述的是筛选或检测受试者中葡萄糖代谢缺陷的方法，包括筛选用于治疗葡萄糖代谢疾病的治疗分子。
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23.发明申请METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ENHANCING SURVIVABILITY OF CELLS, TISSUES, ORGANS, AND ORGANISMS 审中-公开制备方法，组合物和制品提高细胞，组织，器官和有机体的存活率
公开(公告)号：WO2006113914A3
公开(公告)日：2007-04-19
申请号：PCT/US2006015158
申请日：2006-04-20
Applicant: HUTCHINSON FRED CANCER RES , ROTH MARK B , MORRISON MIKE , GOLDMARK JESSE , BLACKSTONE ERIC
Inventor： ROTH MARK B , MORRISON MIKE , GOLDMARK JESSE , BLACKSTONE ERIC
CPC classification number: A61K33/04 , A01N1/02 , A01N1/0226 , A61K31/095 , A61K31/165 , A61K31/185 , A61K31/21 , A61K31/26 , A61K31/275 , A61K31/555 , A61K31/66 , A61K45/06 , Y10S514/921 , A61K2300/00
Abstract: The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.
Abstract translation: 本发明涉及氧还原剂和其它活性化合物在体内或整个生物体中的细胞，组织和/或器官中的用途，除了提高其生存性之外。 它包括组合物，方法，制品和用于提高生存能力的装置，以及用于在这些生物材料中的任何一种中实现淤滞或止血，从而保护和/或保护它们。 在具体实施方案中，还使用所述活性化合物进行器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。
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24.发明申请METHODS, COMPOSITIONS AND DEVICES FOR INDUCING STASIS IN TISSUES AND ORGANS 审中-公开用于诱导组织和器官中的病症的方法，组合物和装置
公开(公告)号：WO2005041656A3
公开(公告)日：2005-08-25
申请号：PCT/US2004035034
申请日：2004-10-22
Applicant: HUTCHINSON FRED CANCER RES , ROTH MARK B
Inventor： ROTH MARK B
IPC: A01N1/02 , A61K33/00 , A61K33/04 , A61K51/00 , B65D81/20 , C12M1/04 , C12N5/00 , C12N5/06 , C12N15/06
CPC classification number: C12N5/00 , A01N1/02 , A01N1/0221 , C12N2500/02
Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.
Abstract translation: 本发明涉及使用氧拮抗剂诱导组织中的淤滞，包括全部或部分器官。 它包括用于在组织中实现淤滞的方法和装置，以保护和/或保护它们。 在具体实施方案中，提供了用于保持用于移植的组织的保存方法和装置。
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25.发明申请METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS 审中-公开HIF调节化合物的制备方法，组合物和制品
公开(公告)号：WO2008040002A9
公开(公告)日：2009-04-16
申请号：PCT/US2007079948
申请日：2007-09-28
Applicant: HUTCHINSON FRED CANCER RES , ROTH MARK B , BUDDE MARK
Inventor： ROTH MARK B , BUDDE MARK
CPC classification number: A61K33/04 , A01N1/0205 , A01N1/0226 , A61K31/095 , A61K33/00 , A61K45/06
Abstract: The present invention generally relates to the modulation of hypoxia- inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis.
Abstract translation: 本发明一般涉及使用本文公开的化合物和方法调节缺氧诱导因子（HIF）。 这些化合物和方法可以用于预防，预处理和/或治疗与HIF相关的病症或状态，例如缺氧和缺血相关的病症和诱导瘀血。
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Patent Agency Ranking
公开(公告)号：WO2009003061A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068232
申请日：2008-06-25
Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER , ROTH, Mark, B. , MORRISON, Mike
Inventor： ROTH, Mark, B. , MORRISON, Mike
CPC classification number: C07K17/14 , A61K33/04 , A61K38/063 , A61K38/38 , A61K38/385 , A61K2300/00
Abstract: The present invention concerns the use of polychalcogenide compositions on cells, tissue, organs, and organisms to enhance their survivability. It includes compositions, compounds, methods, articles of manufacture and apparatuses for enhancing survivability and for protecting them from or treating them for injury or damage. In specific embodiments, there are also therapeutic methods and apparatuses for hypoxic/ischemic injury, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the polychalcogenide compositions described.
Abstract translation: 本发明涉及将多硫族元素组合物用于细胞，组织，器官和生物体以提高其生存性的用途。 它包括组合物，化合物，方法，制品和用于增强生存能力并用于保护它们免受伤害或损伤的装置。 在具体实施方案中，还描述了使用所述多硫属元素组合物的缺氧/缺血性损伤，器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。
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27.发明申请METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS 审中-公开方法，组成和制备HIF调节化合物的制品
公开(公告)号：WO2008040002A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/079948
申请日：2007-09-28
Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER , ROTH, Mark, B. , BUDDE, Mark
Inventor： ROTH, Mark, B. , BUDDE, Mark
CPC classification number: A61K33/04 , A01N1/0205 , A01N1/0226 , A61K31/095 , A61K33/00 , A61K45/06
Abstract: The present invention generally relates to the modulation of hypoxia- inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis.
Abstract translation: 本发明一般涉及使用本文公开的化合物和方法调节缺氧诱导因子（HIF）。 这些化合物和方法可以用于预防，预处理和/或治疗与HIF相关的状况或状态，例如缺氧和缺血相关病症以及诱导停滞。
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28.发明申请METHODS, COMPOSITIONS AND DEVICES FOR INDUCING STASIS IN CELLS, TISSUES, ORGANS, AND ORGANISMS 审中-公开用于诱导细胞，组织，器官和器官中的沉积的方法，组合物和装置
公开(公告)号：WO2005041655A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034980
申请日：2004-10-22
Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER , ROTH, Mark, B.
Inventor： ROTH, Mark, B.
IPC: A01N1/02
CPC classification number: C12N5/00 , A01N1/02 , A01N1/0221 , C12N2500/02
Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for' bypass surgery, neurodegeneration, hypothermia, and cancer is provided.
Abstract translation: 本发明涉及氧气拮抗剂在体内或整个体内在细胞，组织和/或器官中诱导淤滞的用途。 它包括用于在任何这些生物材料中实现淤滞的方法和装置，以便保存和/或保护它们。 在具体实施方案中，提供了用于器官移植，热疗，伤口愈合，出血性休克，用于“旁路手术，神经变性，低体温”和癌症的心脏停搏的治疗方法和装置。
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公开(公告)号：WO02101018A3
公开(公告)日：2003-10-16
申请号：PCT/US0218518
申请日：2002-06-10
Applicant: HUTCHINSON FRED CANCER RES , ROTH MARK B , PADILLA PAMELA
Inventor： ROTH MARK B , PADILLA PAMELA
CPC classification number: G01N33/5011 , A01N1/02 , A01N1/0278 , C12N1/04 , G01N33/5082 , G01N33/5088
Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.
Abstract translation: 本发明涉及在缺氧或缺氧条件下培养生物材料以诱导淤滞或悬浮动画的组合物和方法。 包括筛选引起淤滞的化合物或增加瘀血能力的化合物的方法。 这种方法具有保护生物材料以及减少或预防生物材料创伤的后果。 还考虑了用于筛选在缺氧条件下比正常氧条件下活性或更有活性的化合物的方法。 这样的方法可用于鉴定将在其中肿瘤细胞存活的缺氧条件下操作的抗肿瘤化合物。
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30.发明申请METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR TREATING SHOCK AND OTHER ADVERSE CONDITIONS 审中-公开方法，组合物和制造物品处理震动和其他不利条件
公开(公告)号：WO2007124447A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/067128
申请日：2007-04-20
Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER , ROTH, Mark, B. , BLACKSTONE, Eric , MORRISON, Mike
Inventor： ROTH, Mark, B. , BLACKSTONE, Eric , MORRISON, Mike
Abstract: The present invention concerns the use of active compounds for inducing apnea and treating shock, in addition to enhancing the survivability of a subject. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving these effects.
Abstract translation: 本发明涉及活性化合物用于诱导呼吸暂停和治疗休克的用途，以及增强受试者的生存性。 它包括组合物，方法，制品和用于提高生存性和实现这些效果的装置。
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