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    ANTIAGING AGENT
    21.
    发明申请
    ANTIAGING AGENT 审中-公开
    抗菌剂

    公开(公告)号：WO1998029093A1

    公开(公告)日：1998-07-09

    申请号：PCT/JP1997004859

    申请日：1997-12-25

    Applicant: SHISEIDO COMPANY, LTD. ,  INOMATA, Shinji

    Inventor： SHISEIDO COMPANY, LTD.

    IPC: A61K07/48

    CPC classification number: A61Q1/02 ,  A61K8/97 ,  A61K2800/782 ,  A61Q19/08

    Abstract: An antiaging agent containing a solvent extract of catechu as the active ingredient. It has an elastase inhibitory activity, can keep the liveliness and elasticity of the skin, and can maintain the youthfulness of the skin.

    Abstract translation: 含有儿茶素溶剂提取物作为活性成分的抗衰老剂。 它具有弹性蛋白酶抑制活性，可以保持皮肤的活力和弹性，并能保持皮肤的青春。

    POWDER COATED WITH SPARINGLY SOLUBLE ULTRAVIOLET ABSORBER
    22.
    发明申请
    POWDER COATED WITH SPARINGLY SOLUBLE ULTRAVIOLET ABSORBER 审中-公开
    粉末涂料，具有可分散的超紫外线吸收剂

    公开(公告)号：WO1998009610A1

    公开(公告)日：1998-03-12

    申请号：PCT/JP1997003149

    申请日：1997-09-08

    Applicant: SHISEIDO COMPANY, LTD. ,  OGAWA, Katsuki ,  TAKATA, Sadaki ,  NANBA, Tomiyuki ,  YOSHINO, Koji

    Inventor： SHISEIDO COMPANY, LTD.

    IPC: A61K07/42

    CPC classification number: A61K8/19 ,  A61K8/11 ,  A61K8/27 ,  A61K8/29 ,  A61K8/35 ,  A61K8/4946 ,  A61K8/4973 ,  A61K2800/412 ,  A61Q17/04

    Abstract: A powder coated with a sparingly soluble ultraviolet absorber, prepared either by mixing a molten sparingly soluble ultraviolet absorber with an inorganic or organic powder under heating and gradually cooling the mixture to coat the surface of the powder with the absorber, or by mechanochemically applying a sparingly soluble ultraviolet absorber onto the surface of an inorganic or organic powder by adsorption or coating. The ultraviolet absorber can thus be evenly incorporated in a high concentration into the base material. The coated powder has an excellent stability even after the lapse of time and a high ultraviolet screening effect.

    Abstract translation: 通过在加热下将熔融的微溶紫外线吸收剂与无机或有机粉末混合并逐渐冷却混合物以用吸收剂涂覆粉末的表面，或通过机械化学地施加少量的方法制备的微溶于紫外线吸收剂的粉末 可溶性紫外线吸收剂通过吸附或涂覆在无机或有机粉末的表面上。 因此，紫外线吸收剂可以以高浓度均匀地并入基材。 涂布粉末即使经过时间也具有优异的稳定性和高的紫外线屏蔽效果。

    METHOD OF AND KIT FOR TESTING IN VITRO STIMULATION
    24.
    发明申请
    METHOD OF AND KIT FOR TESTING IN VITRO STIMULATION 审中-公开
    用于体外刺激测试的方法和试剂盒

    公开(公告)号：WO1993004369A1

    公开(公告)日：1993-03-04

    申请号：PCT/JP1992001045

    申请日：1992-08-19

    Applicant: SHISEIDO COMPANY, LTD. ,  HAYASHI, Toshikatsu ,  ITAGAKI, Hiroshi ,  TAMURA, Uhei ,  KATO, Shinobu

    Inventor： SHISEIDO COMPANY, LTD.

    IPC: G01N33/15

    CPC classification number: G01N33/5014

    Abstract: This invention provides a method of in vitro testing for evaluating a degree of stimulation imposed on an organism by an alien substance. The invention provides an in vitro stimulation testing method comprising such steps that, in aqueous solution, an alien substance (substance to be tested) is brought into contact with protein having absorption spectrum at its visible part, variation in absorption spectrum resulting from said contact is measured, and then an amount of said variation is evaluated as an index of stimulation on the organism caused by the substance to be tested. Further provided by this invention is a method of testing an organism stimulation by an alien substance which employs a combination of the abovesaid method with other in vitro stimulation testing methods. A kit for performing such testing methods is also provided. The methods of this invention show a satisfactory correlation with the Draze method as an in vivo testing method.

    Abstract translation: 本发明提供一种体外测试方法，用于评估外来物质对生物体施加的刺激程度。 本发明提供了一种体外刺激试验方法，其包括以下步骤：在水溶液中，外来物质（待测试物质）与其可见部分具有吸收光谱的蛋白质接触，所述接触引起的吸收光谱的变化为 测量，然后评估所述变化的量作为由待测物质引起的对生物体的刺激指数。 本发明进一步提供了一种通过使用上述方法与其它体外刺激测试方法组合的外来物质来测试生物体刺激的方法。 还提供了用于执行这种测试方法的套件。 本发明的方法表现出与Draze方法作为体内测试方法的令人满意的相关性。

    PROCESS FOR PURIFYING POLYPEPTIDE
    27.
    发明申请
    PROCESS FOR PURIFYING POLYPEPTIDE 审中-公开
    净化多肽的方法

    公开(公告)号：WO1991015502A1

    公开(公告)日：1991-10-17

    申请号：PCT/JP1991000421

    申请日：1991-03-29

    Applicant: SHISEIDO COMPANY, LTD. ,  KAMINUMA, Toshihiko ,  IIDA, Toshii ,  TAJIMA, Masahiro

    Inventor： SHISEIDO COMPANY, LTD.

    IPC: C07K01/14

    CPC classification number: C07K1/16 ,  C07K1/36

    Abstract: An improved process for purifying a polypeptide with a packing for high-performance liquid chromatography, which comprises preteating polypeptides produced by various cells into a given state, adjusting the pH of an aqueous solution of the polypeptides to fall within a specified range to thereby remove contaminants by precipitation, and treating the remaining solution with a packing for reversed-phase high-performance liquid chromatography.

    CHROMATOGRAPHIC PACKING AND PREPARATION THEREOF
    28.
    发明申请
    CHROMATOGRAPHIC PACKING AND PREPARATION THEREOF 审中-公开
    色谱包装及其制备

    公开(公告)号：WO1991011711A1

    公开(公告)日：1991-08-08

    申请号：PCT/JP1991000075

    申请日：1991-01-24

    Applicant: SHISEIDO COMPANY, LTD. ,  ITOH, Kenji ,  NAGASHIMA, Hideo ,  JINNO, Kiyokatsu ,  OHTSU, Yutaka

    Inventor： SHISEIDO COMPANY, LTD.

    IPC: G01N30/48

    CPC classification number: B01J20/286 ,  B01J20/103 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3257 ,  B01J20/3261 ,  B01J20/3263 ,  B01J2220/54 ,  B01J2220/58 ,  Y10T428/2993 ,  Y10T428/2995

    Abstract: A chromatographic column packing for liquid chromatography, particularly suitable for the separation of polycyclic aromatic compounds, wherein the surface of the base material is treated with a silane coupling agent of general formula (I), wherein Aro represents an aromatic moiety; R and R represent each independently alkyl, alkenyl, aryl, lower alkoxy or halogen; and R represents lower alkoxy or halogen. Since the functional groups of the coupling agent serve to immobilize the aromatic moiety of the same molecule on the surface of the base material by a number of linkages, a packing with stable and excellent separation characteristics can be obtained.

    Abstract translation: 一种用于液相色谱的色谱柱填料，特别适用于多环芳族化合物的分离，其中基材的表面用通式（I）的硅烷偶联剂处理，其中Aro表示芳族部分; R 1和R 2各自独立地表示烷基，烯基，芳基，低级烷氧基或卤素; R 3表示低级烷氧基或卤素。 由于偶联剂的官能团用于通过多个键将相同分子的芳族部分固定在基材的表面上，因此可以获得具有稳定和优异的分离特性的填料。

    PERCUTANEOUS ABSORPTION PROMOTER AND DERMATOLOGIC PREPARATION FOR EXTERNAL USE
    30.
    发明申请
    PERCUTANEOUS ABSORPTION PROMOTER AND DERMATOLOGIC PREPARATION FOR EXTERNAL USE 审中-公开
    PERCUTANEOUS吸收促进剂和外用制剂

    公开(公告)号：WO1988006041A1

    公开(公告)日：1988-08-25

    申请号：PCT/JP1988000187

    申请日：1988-02-22

    Applicant: SHISEIDO COMPANY LTD. ,  MIYAZAWA, Kiyoshi ,  CHIBA, Tadahiro ,  IWATA, Yuhei ,  TAMURA, Uhei ,  MUROTANI, Isao ,  TAMAKI, Shuya

    Inventor： SHISEIDO COMPANY LTD.

    IPC: A61K47/00

    CPC classification number: A61K9/0014 ,  A61K47/18 ,  Y10S514/947 ,  Y10S514/975

    Abstract: The promoter contains as effective ingredient: (A) one or more of anionic surfactants and one or more of surfactants other than anionic surfactants and containing a nitrogen atom in the molecule,(B) one or more of anionic surfactants and one or more of nonionic surfactants containing no nitrogen atoms in the molecule, (C) one or more of amphoteric surfactants and semi-polar surfactants and one or more of nonionic surfactants containing a nitrogen atom in the molecule, (D) one or more members selected from the group consisting of nonionic, amphoteric, semi-polar, and cationic surfactants containing a nitrogen atom in the molecule and one or more nonionic surfactants containing a nitrogen atom in the molecule, or (E) an amine oxide. The dermatologic preparation for external use contains the percutaneous absorption promoter and a medicinal component.

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