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21.发明公开METHOD AND SYSTEM FOR VALIDATING INSPIRATORY MUSCLE ACTIVITY OF A PATIENT, AND MECHANICAL VENTILATION SYSTEM USING THE SAME 审中-公开VERFAHREN UND SYSTEM ZUR VALIDIERUNG DERATEMMUSKELAKTIVITÄTEINES PATIENTEN UND MECHANISCHES BEATMUNGSSYSTEM DAMIT
公开(公告)号：EP3082587A4
公开(公告)日：2017-09-06
申请号：EP14873101
申请日：2014-12-18
Applicant: ST MICHAEL'S HOSPITAL
Inventor： SINDERBY CHRISTER , BECK JENNIFER , COMTOIS NORMAN
IPC: A61B5/04 , A61B5/00 , A61B5/0488 , A61B5/08 , A61M16/00
CPC classification number: A61B5/4836 , A61B5/0022 , A61B5/0452 , A61B5/0488 , A61B5/08 , A61B5/113 , A61B5/6819 , A61B5/6822 , A61B5/7207 , A61B5/7214 , A61B5/7246 , A61B5/7278 , A61B5/742 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M2230/005 , A61M2230/60
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22.发明授权DETECTION OF DYNAMIC HYPERINFLATION IN SPONTANEOUSLY BREATHING MECHANICALLY VENTILATED PATIENTS 有权在有自主呼吸的机械通气患者动态恶性通货膨胀检测
公开(公告)号：EP2375977B1
公开(公告)日：2014-12-24
申请号：EP10730988.2
申请日：2010-01-07
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer , BECK, Jennifer , COMTOIS, Norman , GRASSELLI, Giacomo
CPC classification number: A61M16/0051 , A61B5/091 , A61M16/0003 , A61M16/024 , A61M2016/003 , A61M2016/0036
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公开(公告)号：EP3852854A1
公开(公告)日：2021-07-28
申请号：EP19862651.7
申请日：2019-09-19
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer , BECK, Jennifer , COMTOIS, Norman
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24.发明公开DEVICE, METHOD AND SYSTEM FOR PROVIDING VENTILATORY ASSIST TO A PATIENT 审中-公开VORRICHTUNG，VERFAHREN UND系统ZURBEATMUNGSUNTERSTÜTZUNGEINES PATIENTEN
公开(公告)号：EP3086831A4
公开(公告)日：2017-09-27
申请号：EP14875136
申请日：2014-12-23
Applicant: ST MICHAEL'S HOSPITAL
Inventor： SINDERBY CHRISTER , BECK JENNIFER , COMTOIS NORMAN
CPC classification number: A61M16/0486 , A61M16/024 , A61M16/04 , A61M16/08 , A61M16/16 , A61M16/161 , A61M16/20 , A61M16/204 , A61M16/205 , A61M2016/0015 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2230/005 , A61M2230/08 , A61M2230/202 , A61M2230/432
Abstract: A device for providing ventilatory assist to a patient is disclosed. The device comprises a manifold having an inspiratory port to receive an inspiratory flow from an inspiratory supply line, an interface port connectable to an external end of an endotracheal tube inserted in a patient's trachea and an expiratory port configured to receive an expiratory flow from the endotracheal tube via the interface port. An inspiratory lumen has a distal end insertable in the endotracheal tube. A cross-section of the inspiratory lumen is smaller than that of the endotracheal tube to allow gas flowing in the endotracheal tube. The inspiratory flow is directed to the inspiratory lumen, or to the endotracheal tube, or at once to the inspiratory lumen and to the endotracheal tube. A ventilatory assist system and method using the device are also disclosed.
Abstract translation: 公开了一种用于为患者提供通气辅助的装置。 该装置包括歧管，该歧管具有吸气端口以接收来自吸气供应管线的吸气流，接口端口可连接到插入患者气管中的气管内插管的外端，呼气端口配置为接收来自气管内的呼气流 通过接口端口。 吸气腔具有可插入气管内管的远端。 吸气管腔的横截面小于气管内管的横截面以允许气体在气管内管中流动。 吸气流被引导至吸气管腔，或引导至气管内管，或者立即引至吸气管腔和气管内管。 还公开了使用该装置的通气辅助系统和方法。
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公开(公告)号：EP2381843B1
公开(公告)日：2016-06-01
申请号：EP10731004.7
申请日：2010-01-15
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer , BECK, Jennifer
IPC: A61B5/08 , A61B5/0488 , A61B5/091
CPC classification number: A61B5/091 , A61B5/037 , A61B5/0488 , A61B5/087
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Patent Agency Ranking26.发明公开METHOD AND SYSTEM FOR QUANTIFYING TIMING DISCREPANCIES BETWEEN INSPIRATORY EFFORT AND VENTILATORY ASSIST 审中-公开方法和系统进行定量定时分歧呼吸努力和呼吸支持之间
公开(公告)号：EP2779896A1
公开(公告)日：2014-09-24
申请号：EP12848806.1
申请日：2012-11-16
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer , COMTOIS, Norman , BECK, Jennifer , EMTELL, Pär , KOCK, Michael
IPC: A61B5/08 , A61B5/0488 , A61M16/00
CPC classification number: A61M16/0051 , A61B5/04001 , A61B5/04884 , A61B5/08 , A61B5/0809 , A61B5/742 , A61M16/00 , A61M16/0069 , A61M16/021 , A61M2016/0021 , A61M2205/502 , A61M2210/1014 , A61M2230/40 , A61M2230/60
Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.
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27.发明公开DETERMINING PATIENT- VENTILATOR BREATH CONTRIBUTION INDEX IN SPONTANEOUSLY BREATHING, MECHANICALLY VENTILATED PATIENTS 审中-公开在有自主呼吸的机械通气患者病人呼吸贡献指数的测定
公开(公告)号：EP2320793A1
公开(公告)日：2011-05-18
申请号：EP09809154.9
申请日：2009-08-26
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer
CPC classification number: A61B5/08 , A61B5/0488 , A61B5/087 , A61B5/687 , A61M16/021 , A61M2016/0039 , A61M2230/60 , A61M2230/005
Abstract: The present invention relates to a system and method for determining a patient-ventilator breath contribution index in a spontaneously breathing, mechanically ventilated patient. A patient's efficiency to generate an inspiratory volume without mechanical ventilatory assist and a patient's efficiency to generate an inspiratory volume with mechanical ventilatory assist are calculated and used to determine the patient-ventilator breath contribution index.
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公开(公告)号：EP3469623A2
公开(公告)日：2019-04-17
申请号：EP17812350.1
申请日：2017-06-09
Applicant: University Health Network , St. Michael's Hospital
Inventor： ZARRINE-AFSAR, Arash , GINSBERG, Howard Joeseph , WOOLMAN, Michael
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公开(公告)号：EP2983695A1
公开(公告)日：2016-02-17
申请号：EP14783323.0
申请日：2014-03-19
Applicant: Sunnybrook Research Institute , St. Michael's Hospital
Inventor： DUMONT, Daniel , VAN SLYKE, Paul , LEE, Warren
IPC: A61K38/18 , A61K31/13 , A61K31/195 , A61K31/216 , A61K31/351 , A61K31/7056 , A61K39/395 , A61K47/48 , A61P31/16
CPC classification number: A61K38/08 , A61K31/13 , A61K31/195 , A61K31/215 , A61K31/7012 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/60 , C07K14/515 , A61K2300/00
Abstract: The present disclosure provides methods and uses of Tie2 agonists alone or in combination with antiviral agents. In particular, the present disclosure provides methods and uses for treating influenza, treating a bacterial superinfection associated with influenza and decreasing lung endothelial leakage. The disclosure also provides compositions comprising (a) a Tie2 agonist and (b) an antiviral agent and methods and uses thereof.
Abstract translation: 本公开提供了Tie2激动剂单独或与抗病毒剂组合的方法和用途。 具体而言，本公开提供了治疗流感，治疗与流感相关的细菌重复感染和减少肺内皮渗漏的方法和用途。 本公开还提供了包含（a）Tie2激动剂和（b）抗病毒剂的组合物及其方法和用途。
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30.发明公开METHOD AND SYSTEM FOR PATIENT-SYNCHRONIZED VENTILATORY ASSIST WITH ENDOTRACHEAL THROUGH-FLOW 审中-公开与之同步呼吸支持气管潮流计算病人的方法和系统
公开(公告)号：EP2588177A1
公开(公告)日：2013-05-08
申请号：EP11800020.7
申请日：2011-06-29
Applicant: St. Michael's Hospital
Inventor： SINDERBY, Christer , BECK, Jennifer
Abstract: A ventilatory assist system and method are disclosed. The system comprises a tube for connection to a patient's airway, inspiratory and expiratory tube lumens connected to the tube, an inspiratory air source connected to the inspiration tube lumen, and a controller of air pressure in the expiratory tube lumen. The pressure controller is responsive to a physiological breathing signal representative of patient's inspiratory effort to allow air flow through the expiratory tube lumen during a patient's expiration phase, partially restricting the air flow through the expiratory tube lumen to a so minimum air flow during a patient's inspiration phase. During both respiratory phases, a unidirectional air flow is produced through the inspiratory and expiratory tube lumens to prevent air expired by the patient from being breathed again. The physiological breathing signal allows synchronization of the ventilatory assist with breathing efforts of the patient.
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