公开(公告)号：US09669105B2

公开(公告)日：2017-06-06

申请号：US13881976

申请日：2011-10-26

Applicant: Dae Seong Im ,  Jae Min Lee ,  Jong Soo Lee ,  Sung Min Bae ,  Se Chang Kwon

Inventor： Dae Seong Im ,  Jae Min Lee ,  Jong Soo Lee ,  Sung Min Bae ,  Se Chang Kwon

IPC: A61K9/00 ,  A61K38/21 ,  A61K47/26 ,  A61K47/48 ,  C07K14/56 ,  C07K16/46

CPC classification number: A61K47/48415 ,  A61K9/0019 ,  A61K38/212 ,  A61K47/26 ,  A61K47/68 ,  A61K47/6813 ,  C07K14/56 ,  C07K16/46 ,  C07K2319/30

Abstract: Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.

公开(公告)号：US20140181118A1

公开(公告)日：2014-06-26

申请号：US14116079

申请日：2011-12-30

Applicant: Nak Kyu Lee ,  Hye Jin Lee ,  Jung Han Song ,  Jeanho Park ,  Sung Min Bae ,  Hyoung Wook Lee ,  Chul Young Kim

Inventor： Nak Kyu Lee ,  Hye Jin Lee ,  Jung Han Song ,  Jeanho Park ,  Sung Min Bae ,  Hyoung Wook Lee ,  Chul Young Kim

IPC: G06F17/30

CPC classification number: G06F17/30321 ,  G06Q10/10 ,  G06Q50/184

Abstract: The present invention relates to a method for outputting a convergence index, and more particularly, to a method for outputting a convergence index by utilizing patent information. According to the method for outputting the convergence index of the present invention, the convergence index can be outputted by using time information related to a patent which is included in a patent group, a patent classification, and an industrial classification that corresponds to the patent classification. The method for outputting the convergence index of the present invention systematically outputs the convergence index by using patent data, which is an objective data, thereby outputting the convergence index which is objective and appropriate.

Abstract translation: 本发明涉及一种用于输出收敛指数的方法，更具体地说，涉及一种通过利用专利信息来输出收敛指数的方法。 根据本发明的收敛指标的输出方法，可以通过使用与专利分类相关的专利的时间信息，专利分类，对应于专利分类的工业分类，输出收敛指数 。 用于输出本发明的收敛指标的方法通过使用作为客观数据的专利数据系统地输出收敛指数，从而输出客观和适当的收敛指数。

公开(公告)号：US20120294829A1

公开(公告)日：2012-11-22

申请号：US13574039

申请日：2011-01-18

Applicant: Mi Ji Lee ,  Jae Min Lee ,  Byung Sun Lee ,  Sung Min Bae ,  Se Chang Kwon

Inventor： Mi Ji Lee ,  Jae Min Lee ,  Byung Sun Lee ,  Sung Min Bae ,  Se Chang Kwon

IPC: A61K38/19

CPC classification number: A61K9/0019 ,  A61K38/193 ,  A61K47/12 ,  A61K47/26 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/535

Abstract: Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.

Abstract translation: 本发明公开了一种允许长效G-CSF缀合物的液体制剂，其具有改善的体内持续时间和稳定性，在长时间储存​​时是稳定的。 它包括以缓冲液和甘露醇为特征的稳定剂组合物。 没有人体血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效G-CSF缀合物的极好的储存稳定性。

公开(公告)号：US07737260B2

公开(公告)日：2010-06-15

申请号：US10535232

申请日：2004-11-13

Applicant: Young Min Kim ,  Dae Jin Kim ,  Sung Min Bae ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Young Min Kim ,  Dae Jin Kim ,  Sung Min Bae ,  Chang Ki Lim ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: C07K16/00

CPC classification number: A61K47/68 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/505 ,  C07K14/535 ,  C07K14/56 ,  C07K14/61 ,  C07K16/46 ,  C07K19/00 ,  C07K2317/52 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/30

Abstract: Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.

Abstract translation: 公开了具有改善的体内持续时间和稳定性的蛋白质缀合物及其用途。 蛋白质缀合物包括生理活性多肽，非肽聚合物和免疫球蛋白Fc片段。 由于三种成分共价连接，因此蛋白质缀合物延长了生理活性多肽的体内持续时间和增强的稳定性。 蛋白质缀合物以较高的水平保持体内活性，并显着增加生理活性多肽的血清半衰期，具有诱导不良免疫反应的风险较小。 因此，蛋白质缀合物可用于开发各种多肽药物的长效制剂。

公开(公告)号：US07704709B2

公开(公告)日：2010-04-27

申请号：US11975541

申请日：2007-10-19

Applicant: Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

Inventor： Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

IPC: C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12N15/19 ,  C12N15/27 ,  C12N15/63 ,  C12N15/70 ,  C12N15/72

CPC classification number: C07K14/535 ,  C07K2319/034 ,  C07K2319/75 ,  C12N15/625 ,  C12N15/70

Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid.

Abstract translation: 通过培养用包含编码修饰的hG-CSF的基因的表达载体转化的微生物来产生修饰的人粒细胞集落刺激因子（hG-CSF），以产生和分泌经修饰的hG-CSF至周质，所述修饰的hG-CSF 通过将野生型hG-CSF（SEQ ID NO：2）的第1，第2，第3和第17氨基酸中的至少一个替换为其他氨基酸而获得。

公开(公告)号：US07052867B2

公开(公告)日：2006-05-30

申请号：US10182040

申请日：2001-01-19

Applicant: Se-Chang Kwon ,  Sung-Youb Jung ,  Ki-Doo Choi ,  Cha-Soon Kim ,  Sung-Min Bae ,  Gwan-Sun Lee

Inventor： Se-Chang Kwon ,  Sung-Youb Jung ,  Ki-Doo Choi ,  Cha-Soon Kim ,  Sung-Min Bae ,  Gwan-Sun Lee

IPC: C12P21/06 ,  C12N15/00 ,  C12N15/21

CPC classification number: C07K14/245 ,  C07K14/56 ,  C07K2319/02 ,  C12N15/70

Abstract: Disclosed in this invention are an expression vector for the secretive production of human interferon alpha (hIFNα) comprising a polynucleotide encoding a modified E. coli thermostable enterotoxin II signal sequence and a polynucleotide encoding hIFNα ligated to the 3′-end thereof; a microorganism transformed with the expression vector; and a process for secretively producing human interferon by culturing the microorganism, the process being capable of secreting a soluble form of active hIFNα, which does not contain an additional methionine residue at its N-terminal, into the periplasm of an E. coli cell.

Abstract translation: 在本发明中公开了用于分泌生产人干扰素α（hIFNα）的表达载体，其包含编码修饰的大肠杆菌热稳定性肠毒素II信号序列的多核苷酸和编码连接于其3'端的hIFNα的多核苷酸; 用表达载体转化的微生物; 以及通过培养微生物分泌生产人类干扰素的方法，该方法能够将在其N-末端不含另外的甲硫氨酸残基的可溶形式的活性hIFNα分泌到大肠杆菌细胞的周质中。

公开(公告)号：US09492507B2

公开(公告)日：2016-11-15

申请号：US13638786

申请日：2011-04-04

Applicant: Dae Hae Song ,  Jae Hee Shin ,  Young Jin Park ,  Dae Seong Im ,  Sung Min Bae ,  Se Chang Kwon

Inventor： Dae Hae Song ,  Jae Hee Shin ,  Young Jin Park ,  Dae Seong Im ,  Sung Min Bae ,  Se Chang Kwon

IPC: C07K14/62 ,  A61K38/28 ,  A61K47/48

CPC classification number: A61K38/28 ,  A61K47/68 ,  A61K47/6883 ,  C07K14/62 ,  C07K2319/30

Abstract: The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.

Abstract translation: 本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。 本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。

公开(公告)号：US09422349B2

公开(公告)日：2016-08-23

申请号：US12669372

申请日：2008-07-16

Applicant: Sung Youb Jung ,  Chang Ki Lim ,  Dae Hae Song ,  Sung Min Bae ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Sung Youb Jung ,  Chang Ki Lim ,  Dae Hae Song ,  Sung Min Bae ,  Young Hoon Kim ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: C07K14/605 ,  A61K38/26 ,  C07K14/46 ,  C07K14/575

CPC classification number: C07K14/46 ,  A61K38/26 ,  C07K14/57563 ,  C07K14/605

Abstract: The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.

Abstract translation: 本发明涉及具有高活性的N-末端氨基酸修饰的促胰岛素肽以及包含其的药物组合物。 根据本发明的促胰岛素肽衍生物显示出在天然和其他促胰岛素肽类似物中未观察到的治疗效果。 因此，可以有效地提供促胰岛素肽衍生物和包含其的本发明的药物组合物用于治疗疾病。

公开(公告)号：US09367577B2

公开(公告)日：2016-06-14

申请号：US14116079

申请日：2011-12-30

Applicant: Nak Kyu Lee ,  Hye Jin Lee ,  Jung Han Song ,  Jeanho Park ,  Sung Min Bae ,  Hyoung Wook Lee ,  Chul Young Kim

Inventor： Nak Kyu Lee ,  Hye Jin Lee ,  Jung Han Song ,  Jeanho Park ,  Sung Min Bae ,  Hyoung Wook Lee ,  Chul Young Kim

IPC: G06F17/30 ,  G06Q10/10 ,  G06Q50/18

CPC classification number: G06F17/30321 ,  G06Q10/10 ,  G06Q50/184

Abstract: The present invention relates to a method for outputting a convergence index, and more particularly, to a method for outputting a convergence index by utilizing patent information. According to the method for outputting the convergence index of the present invention, the convergence index can be outputted by using time information related to a patent which is included in a patent group, a patent classification, and an industrial classification that corresponds to the patent classification. The method for outputting the convergence index of the present invention systematically outputs the convergence index by using patent data, which is an objective data, thereby outputting the convergence index which is objective and appropriate.

Abstract translation: 本发明涉及一种用于输出收敛指数的方法，更具体地说，涉及一种通过利用专利信息来输出收敛指数的方法。 根据本发明的收敛指标的输出方法，可以通过使用与专利分类相关的专利的时间信息，专利分类，对应于专利分类的工业分类，输出收敛指数 。 用于输出本发明的收敛指标的方法通过使用作为客观数据的专利数据系统地输出收敛指数，从而输出客观和适当的收敛指数。

公开(公告)号：US08829163B2

公开(公告)日：2014-09-09

申请号：US13574029

申请日：2011-01-18

Applicant: Sung Min Bae ,  Dae Seong Im ,  Min Young Kim ,  Chang Ki Lim ,  Sung Youb Jung ,  Se Chang Kwon

Inventor： Sung Min Bae ,  Dae Seong Im ,  Min Young Kim ,  Chang Ki Lim ,  Sung Youb Jung ,  Se Chang Kwon

IPC: A61K39/00 ,  C07K16/00 ,  A61K47/02 ,  A61K47/26 ,  A61K47/48 ,  A61K47/18 ,  A61K9/00 ,  A61K47/10

CPC classification number: A61K47/02 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  A61K47/6811 ,  A61K47/6835

Abstract: Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting EPO conjugates.

Abstract translation: 公开了一种液体制剂，其允许具有改善的体内持续时间和稳定性的长效EPO缀合物在长时间储存​​时是稳定的。 它包括以缓冲液和甘露醇为特征的稳定剂组合物。 没有人血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效EPO共轭物的极好的储存稳定性。