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    SINGLE LINKER FABFV ANTIBODIES AND METHODS OF PRODUCING SAME
    26.
    发明专利
    SINGLE LINKER FABFV ANTIBODIES AND METHODS OF PRODUCING SAME 未知

    公开(公告)号：CA2895608A1

    公开(公告)日：2014-06-26

    申请号：CA2895608

    申请日：2013-12-20

    Applicant: UCB BIOPHARMA SPRL ,  UCB BIOPHARMA SPRL

    Inventor： DAVE EMMA ,  HEYWOOD SAM PHILLIP ,  HUMPHREYS DAVID PAUL

    IPC: C07K16/46 ,  C07K16/18 ,  C07K16/28

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    Cap for an injector
    28.
    发明授权
    Cap for an injector 有权

    公开(公告)号：US11324896B2

    公开(公告)日：2022-05-10

    申请号：US16608400

    申请日：2018-04-25

    Applicant: UCB Biopharma SPRL

    Inventor： Barry Alan Knight ,  Marko Plevnik ,  Norihiko Inoue ,  Jamie Buckley ,  Lisa Hornsey

    IPC: A61M5/32

    Abstract: Provided is a cap for an injector comprising a syringe with a needle cover. The cap comprises a cap body defining an inner and outer cap body; provided to the inner cap body, a grip for gripping the needle cover of said syringe; provided to the outer cap body, an opposing pair of recessed portions, wherein each recessed portion defines a recess base, and wherein each recessed portion is bounded by a peripheral lip; and provided to the recess base of each recessed portion, an over-coating. The cap body comprises a generally rigid material and each over-coating comprises a more flexible material. Each peripheral lip defines banks that extend beyond the over-coating of the recess base.

    Sequence symmetric modified IgG4 bispecific antibodies
    29.
    发明授权
    Sequence symmetric modified IgG4 bispecific antibodies 有权

    公开(公告)号：US11059911B2

    公开(公告)日：2021-07-13

    申请号：US16242378

    申请日：2019-01-08

    Applicant: UCB Biopharma SPRL

    Inventor： David Paul Humphreys ,  Shirley Jane Peters

    IPC: C07K16/46 ,  C07K16/00

    Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:
    the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and
    optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

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