Abstract:
Object of the present invention is a method for obtaining the selective protection of normal cells and, at the same time, the selective eradication of tumor cells having an inactive p53 pathway. Further objects of the present invention are the uses of the compounds of the method, pharmaceutical compositions and kits, comprising such compounds as active principles, and use of the C3H10T1/2 cells for implementing methods for the eradication of tumor cells having an inactive p53 pathway.
Abstract:
It is described a method to determine the toxicity caused by exposure to chemical and physical agents consisting in exposing some biological material to said agents and in measuring with an oxygen electrode the O2 concentration change which is due to the respiratory activity of said material, after having added a convenient substratum to the solution with which the material is in contact, said method being characterised in that the biological material used is such that, at the maximum speed of its metabolism, the residual concentration of O2 is higher than zero.
Abstract:
Hereafter are described diamond-based composite materials consisting of sub-micrometric or nanometric dispersions of metallic elements semiconductors and their inorganic compounds in diamond-structured carbon polymorphic matrices together with the techniques and apparatus for their preparation.
Abstract:
The invention concerns a on-line evaluation of failure due to rotoric eccentricity in generators/synchronous motors by measuring inner currents of statoric winding and spectral analyses of analytical signals derived from the same by complex transformation, said method comprising the steps of: a1. Eventually a commissioning a1. step to determine parameters (a, b, c, prif), necessary in an eventual folloqing step f.; a. measurement of instantaneous inner statoric currents b. calculation of complex vectors i (q)) by formula wherein alpha = ej(2pi/n); c. spectral analyses of analytical signal associated with complex vectors of p±1 order: i(p-1), i(p+1); d. extraction of amplitudes of spectral components S1, D1, S2, D2, wherein: S7=amplitude of component with frequence f of current i(p-1); D1= amplitude of component with frequence (f-f/p) of current KM) S2= amplitude of component with frequence f of current i(p+1) D2= amplitude of component with frequence (f+f/p) of current i(p+1) p=number of polar couples of synchronous machine e. calculation of instantaneous eccentricity applying formulae and f. eventually, and only if preliminary commissioning step was carried out, to increase precision under load, it is possible, also measuring tension, estimating field angle (zeta, zeta) and thus corrective coefficient Kappa(zeta).
Abstract:
The present invention relates to a method for measurement of magnetic gap reduction in three-phase synchronous machines by "tracking of maximum and minimum amplitude tracking" of spatial trajectories of multipolar spatial vectors obtained from "split phase" statoric currents (parallel currents of a phase with parallel connection of polar bands) comprising the steps of: a.1 eventual commissioning to determine parameters (a, b, c, Prif) a. measurement of instantaneous inner statoric currents; b.calculation of complex vectors by formula (3), b1. Optional: eventual band-pass pre-filtering [f-f/p, f+f/p] to eliminate further harmonics c. tracking of maximum and minimum module of vectors of p±1 order: : A1?B1?, A2,?B2?; d. calculation of sign of B1 and B2 e. calculation of instantaneous eccentricity applying formulae (27), (28), of formulae (19), (20), (23), (24) f. calculation of eccentricity angle by formulae (29), (30), g. in order to increase the precision under load, it is possible, by measuring also tension, estimating field angle (zed, ?), and thus a corrective coefficient ?(?).
Abstract:
A gas-sensing device having a photonic structure, which comprises a multilayer structure (39) made of porous material comprising a periodic multilayer (22; 32) configured for generating Bloch surface waves, and means (23; 33) for directing a light beam (25; 36) incident upon said device (30) towards said multilayer structure (22; 32) in attenuated-total-reflection (ATR) conditions in order to generate said Bloch surface waves, said periodic multilayer (22; 32) comprising a first sensitive face (32e) that is free so as to be exposed to the gas, and a second face (32f) opposite to said first sensitive face (32e). According to the invention, said second face (32f) of said periodic multilayer (32) is set facing said means (33) for directing the incident light beam (36) in ATR conditions, and said multilayer structure (32) made of porous material is fixed to said means (33) for directing the incident light beam (36) in ATR conditions via a bonding layer (34) and a transparent substrate layer (31).
Abstract:
The subject invention discloses a method for the preparation of a dual structure cellular ceramic object where a dispersion of a ceramic precursor a chain-growth or step- growth polymer precursor and a solvent is heated to a first temperature at a first rate followed by heating to a second temperature at a second rate and holding the temperature to form a sintered dual structure cellular ceramic object which is then cooled at a third rate to room temperature. The dual structure cellular ceramic object has a dense surface layer over at least a portion of the object that abruptly yet smoothly and continuously transitioning into a porous ceramic.
Abstract:
A process for reducing and/or removing sour gases, such as carbon dioxide and hydrogen sulfide, from natural gas or from gas associated with oil reservoirs, by means of the formation of mixed hydrates, wherein a selective separation is carried out both during the hydrates decomposition, under pressure conditions close to atmospheric pressure and temperatures little below zero, and, preferably, during a preliminary step, with pressures and temperatures close to the equilibrium values.
Abstract:
The invention relates to 1,3,5-benzene derivatives and corresponding radical-anions and radical-cations of the general formula (I): wherein: Z is a group chosen from among C=O, CONH, CONR, CONAr; m is an integer >0, preferably m = 1; A is a group chosen from among the radicals of: biphenylene, carbazole, fluoranthene, fluorene, dibenzothiofene, dibenzofurane, fluorenone, bifluorenylidene, triphenylene, cyclooctatetraene (COT), dibenzocyclooctatetraene (DBCOT), coronene, acenaphtylene, triptycene, azulene, benzo(ghi)fluoranthene, 2-phenyl-l,3,4-oxadiazole, anthracene. R and Ar are alkyl and aryl respectively and have the meaning indicated herein below. The invention also relates to the method for synthesizing said compounds and to their use in particular as components of matrices in the molecular electronics, spintronics and telecom fields.
Abstract:
The invention relates to the use of acetyls alicy lie acid (ASA) in combination with MRP4 channel inhibitors for the treatment of all diseases related to so-called ASA resistance. Particularly preferred among the MRP4 channel inhibitors is dipyridamole. The invention also relates to an in-?itro diagnostic method for identifying ASA- resistant patients and to the associated kit for implementing the diagnostic method.