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    MODULAR CHEMICAL PROBE FOR DETECTION OF AMINO ACID CITRULLINE IN PHYSIOLOGICAL SAMPLES
    22.
    发明申请
    MODULAR CHEMICAL PROBE FOR DETECTION OF AMINO ACID CITRULLINE IN PHYSIOLOGICAL SAMPLES 审中-公开

    公开(公告)号：WO2021016339A1

    公开(公告)日：2021-01-28

    申请号：PCT/US2020/043049

    申请日：2020-07-22

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

    Inventor： KADNIKOV, Dmitry, V. ,  GRANT, Jennifer

    IPC: C07C55/00 ,  C07C57/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

    Abstract: An improved chemical probe for the detection of the amino acid citrulline combines: 1) a reactive head formed of 1,3-dicarbonyl moiety that reacts with a citrulline side chain in an improved manner compared to currently used 1,2-dicarbonyl moieties; and 2) a modular action of the probe where citrulline side chains are labeled first using reactive heads described above, and attachment of a read-out subunit or tag, be it a fluorophore, a nanoparticle, or an antigen is performed separately. The modular nature of the chemical probe increases the sensitivity of the probes due to their smaller size. Additionally, the chemical probes of the present disclosure allow the same sample to be analyzed using a variety of read-out methods.

    STIMULI RESPONSIVE DISPERSANTS FOR ARCHITECTURAL COATINGS
    23.
    发明申请
    STIMULI RESPONSIVE DISPERSANTS FOR ARCHITECTURAL COATINGS 审中-公开

    公开(公告)号：WO2021016337A1

    公开(公告)日：2021-01-28

    申请号：PCT/US2020/043045

    申请日：2020-07-22

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

    Inventor： GLOGOWSKI, Elizabeth M.

    IPC: C09D153/00 ,  C08K3/22 ,  C08L53/00 ,  C08F2438/01 ,  C08F293/005 ,  C08K2003/2241 ,  C08K9/02

    Abstract: A dispersing agent or dispersant formed as a block copolymer for use in surface coating compositions, such as architectural paint compositions, that can alter its properties as a result of changes in environmental conditions is provided. These stimuli -responsive copolymers are synthesized with properties that can be controlled based on number of blocks and block length and/or as a function of pH and temperature. The addition of these copolymers to coating compositions including other additives, such as pigments and/or fillers, can decrease settling rate, control viscosity, and control interfacial activity of the additives in the compositions.

    GOLF SWING IMPROVEMENT TOOL
    24.
    发明申请
    GOLF SWING IMPROVEMENT TOOL 审中-公开

    公开(公告)号：WO2019018373A3

    公开(公告)日：2019-01-24

    申请号：PCT/US2018/042454

    申请日：2018-07-17

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

    Inventor： HUNT, Samuel, B.

    IPC: A63B69/36 ,  A63B60/06 ,  A63B102/32

    Abstract: A golf swing improvement tool is provide that attaches to a golf club, and includes a guide arm contacting the leading forearm of a golfer. An offset arm allows the guide arm to be offset laterally from the longitudinal axis of the golf club. The user adjusts the offset distance to give a specific leading arm-to-club relationship. If the club moves ahead of the desired relationship with the leading arm during the swing, the user will be alerted to this error by the guide arm loosing contact with the forearm.

    CHEMICALLY UNIFORM DILATANT MATERIALS
    25.
    发明申请
    CHEMICALLY UNIFORM DILATANT MATERIALS 审中-公开

    公开(公告)号：WO2018204915A1

    公开(公告)日：2018-11-08

    申请号：PCT/US2018/031377

    申请日：2018-05-07

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

    Inventor： DROSKE, John, P.

    IPC: C08G63/688

    CPC classification number: C08G63/6886

    Abstract: A series of materials that exhibit a range of dilatant properties have been synthesized. The materials show good transparency and are chemically uniform, that is, they consist of a single chemical component. The dilatant properties likely are due to the presence of both aggregated and non-aggregated forms of the oligomers. The degree of dilatancy can be modified by adjusting the monomer composition. The range of dilatant properties, good transparency, and single chemical component nature of the dilatant samples make these materials of particular interest.

    CARBON MICROBEADS WITH HIERARCHICAL STRUCTURE
    27.
    发明申请
    CARBON MICROBEADS WITH HIERARCHICAL STRUCTURE 审中-公开
    具有分级结构的碳微生物

    公开(公告)号：WO2011011579A2

    公开(公告)日：2011-01-27

    申请号：PCT/US2010/042863

    申请日：2010-07-22

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC. ,  GIBSON, Charles, P. ,  KARTHIKEYAN, Annamalai

    Inventor： GIBSON, Charles, P. ,  KARTHIKEYAN, Annamalai

    IPC: C01B31/02

    CPC classification number: C01B31/02 ,  B01D2253/102 ,  B01D2253/304 ,  B01J20/20 ,  B01J20/28004 ,  B01J20/324 ,  B01J20/3293 ,  C01B32/05 ,  C01B32/20 ,  Y02C10/08 ,  Y10T428/249921 ,  Y10T428/2989

    Abstract: The preset invention is a hierarchically- structured carbon microbead and method for forming the microbead utilizing hydrothermal carbonization of a biomass/catalyst mixture to produce partially carbonized amorphous microspheres, wherein the biomass is an inexpensive material containing a high oxygen content component (e.g., sugar, starch, alcohol), and the catalyst is a metal or metal-containing compound, preferably a transition metal compound, and more specifically a transition metal selected from Fe, Co, Ni, Ru, Rh, Pd, Os, Ir, and Pt. Subsequently, a heat treatment is performed where the amorphous microspheres are heated to a temperature that is sufficiently high so as to result in carbonization, graphitization, and production of a carbonaceous coating or shell on the core of the microbead.

    Abstract translation: 本发明是一种分层结构的碳微珠和利用生物质/催化剂混合物的水热碳化来形成微珠的方法，以产生部分碳化的无定形微球体，其中生物质是含有高 氧含量组分（例如糖，淀粉，醇），并且催化剂是金属或含金属化合物，优选过渡金属化合物，并且更具体地选自Fe，Co，Ni，Ru，Rh，Pd ，Os，Ir和Pt。 随后，进行热处理，其中将无定形微球体加热到足够高的温度，以便导致碳微球体核心上的碳质涂层或壳的碳化，石墨化和生成。

    STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS
    28.
    发明申请
    STEREOSPECIFIC ANXIOLYTIC AND ANTICONVULSANT AGENTS WITH REDUCED MUSCLE-RELAXANT, SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS 审中-公开
    具有降低肌肉松弛作用的STEREOSPECIFIC ANXIOLYTIC AND ANTICAVULENTANT AGENTS，SEDATIVE-HYPNOTIC AND ATAXIC EFFECTS

    公开(公告)号：WO2006004945A1

    公开(公告)日：2006-01-12

    申请号：PCT/US2005/023301

    申请日：2005-06-30

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC. ,  COOK, James, M. ,  ZHOU, Hao ,  HUANG, Shengming ,  SARMA, P.V.V.S. ,  ZHANG, Chunchun

    Inventor： COOK, James, M. ,  ZHOU, Hao ,  HUANG, Shengming ,  SARMA, P.V.V.S. ,  ZHANG, Chunchun

    IPC: C07D243/16

    CPC classification number: C07D243/24 ,  C07D243/16 ,  C07D471/06 ,  C07D487/04 ,  C07D487/06

    Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

    Abstract translation: 本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法， 效果。 本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-XXI中任一项所示的化学结构和药学上可接受的载体的化合物，前药或盐。

    METHOD AND APPARATUS FOR PRODUCING AN ELECTRICAL PROPERTY IMAGE OF SUBSTANTIALLY HOMOGENOUS OBJECTS CONTAINING INHOMOGENEITIES
    29.
    发明申请
    METHOD AND APPARATUS FOR PRODUCING AN ELECTRICAL PROPERTY IMAGE OF SUBSTANTIALLY HOMOGENOUS OBJECTS CONTAINING INHOMOGENEITIES 审中-公开
    用于生产含有不均匀性的物质均质物体的电气性能图像的方法和装置

    公开(公告)号：WO2004043253A1

    公开(公告)日：2004-05-27

    申请号：PCT/US2003/035122

    申请日：2003-11-05

    Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

    Inventor： GREGORY, Christopher, William ,  GREGORY, William, D.

    IPC: A61B5/053

    CPC classification number: A61B5/0064 ,  A61B5/0536 ,  A61B5/1077 ,  A61B5/7257

    Abstract: An electrical parameter imaging apparatus and method includes the acquisition of a charge distribution pattern on an array of electrodes that surround an object being imaged. In addition the exterior boundary, or contours of the objects is measured by an array of light beams and associated light sensors. The contour measurement is employed to provide a first estimate of the object geometry needed to compute an electrical parameter image from the acquired charge distribution pattern.

    Abstract translation: 电参数成像装置和方法包括在围绕被成像对象的电极阵列上获取电荷分布图案。 此外，物体的外部边界或轮廓由光束阵列和相关联的光传感器测量。 使用轮廓测量来提供从获取的电荷分布图案计算电参数图像所需的对象几何的第一估计。

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