公开(公告)号：KR1020090122344A

公开(公告)日：2009-11-27

申请号：KR1020097016858

申请日：2008-02-15

Applicant: (주)아모레퍼시픽 ,  주식회사 에스트라

Inventor： 박진우 ,  신광현 ,  권민정 ,  배준호 ,  전도용

IPC: A61K9/10 ,  A61K9/16 ,  A61K31/4709 ,  A61P7/02

CPC classification number: A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/205 ,  A61K9/2077 ,  A61K31/4709

Abstract: PURPOSE: A controlled release agent containing cilostazol and a method for producing the same are provided to maintain the effective drug concentration in blood and improve medicine compliance. CONSTITUTION: A controlled release agent of cilostazol comprise a solid dispersion granule containing 10-80 weight% of cilostazol and 0.1-50 weight% of solubilizing agent and 5-80 weight% of hydrogel forming material. A method for producing the controlled release agent of cilostazol comprises: a step of mixing cilostazol or its pharmaceutically acceptable salt and solubilizing agent to granulate; and a step of mixing the drug granule with hydrogel than granulating.

Abstract translation: 目的：提供含有西洛他唑的控释药及其制备方法，以维持血液中有效的药物浓度，提高药物依从性。 构成：西洛他唑的控释药物包含固体分散颗粒，其含有10-80重量％的西洛他唑和0.1-50重量％的增溶剂和5-80重量％的水凝胶形成材料。 西洛他唑控制释放剂的制备方法包括：将西洛他唑或其药学上可接受的盐和增溶剂混合成粒状的步骤; 以及将药物颗粒与水凝胶混合的步骤，而不是制粒。