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公开(公告)号：KR1020130056956A
公开(公告)日：2013-05-31
申请号：KR1020110122623
申请日：2011-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: C12N5/0698 , A61F2/10 , A61L27/24 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60
Abstract: PURPOSE: A skin equivalent comprising melanocytes and a method preparing a same are provided to manufacture a epidermis layer containing melanocytes and similar to a real skin through a growth and a differentiation induction process without making a layer of melanocytes. CONSTITUTION: A skin equivalent comprises a fibroblast, a keratinocyte, and a melanocyte. The skin equivalent comprises a dermis layer and an epidermis layer. The dermis layer comprises the fibroblast. The epidermis layer comprises the keratinocyte and the melanocyte. The dermis layer comprises more than 2 layers. The dermis layer comprises a first layer containing a collagen and a second layer containing the fibroblast. [Reference numerals] (AA,FF) Epidermis layer; (BB) Dead skin forming cell; (CC,GG) Dermis layer; (DD) H&E dying; (EE) Fibroblasts; (HH) HMB45 dying; (II) Melanocytes
Abstract translation: 目的：提供包含黑素细胞的皮肤等同物及其制备方法，以通过生长和分化诱导过程制造含有黑素细胞并与实际皮肤相似的表皮层，而不会形成黑色素细胞层。 构成：皮肤当量包括成纤维细胞，角质形成细胞和黑素细胞。 皮肤等效物包含真皮层和表皮层。 真皮层包含成纤维细胞。 表皮层包含角质形成细胞和黑素细胞。 真皮层包含2层以上。 真皮层包含含有胶原蛋白的第一层和含有成纤维细胞的第二层。 （AA，FF）表皮层; （BB）死皮成形细胞; （CC，GG）真皮层; （DD）H＆E死亡; （EE）成纤维细胞; （HH）HMB45死亡; （II）黑素细胞
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公开(公告)号：KR1020130051266A
公开(公告)日：2013-05-20
申请号：KR1020110116517
申请日：2011-11-09
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An anti-aging composition containing one or more materials selected from the group consisting of a Pinus densiflora extract and a Rhynchosia nolubilis extract is provided to reduce wrinkling, to enhance skin elasticity, and to maintain UV protection efficiency. CONSTITUTION: An anti-aging composition contains one or more materials selected from the group consisting of a Pinus densiflora extract and a Rhynchosia nolubilis extract. The composition contains 0.001-40% of Pinus densiflora extract. The composition contains 0.001-50% of Rhynchosia nolubilis extract. The extracts are mixed in a weight ratio of 0.1-10:1. The composition is used for anti-wrinkling and anti-aging without side effects such as photosensitization. [Reference numerals] (AA) Small bean extract(ppm); (BB) Pine needle extract(ppm); (CC) Mixture of pine needle : small beam = 1 : 1(ppm)
Abstract translation: 目的：提供一种抗衰老组合物，其含有选自松属松属提取物和Rhynchosia nolubilis提取物中的一种或多种材料，以减少皱纹，增强皮肤弹性和保持UV保护效率。 构成：抗衰老组合物含有一种或多种选自松属松属提取物和Rhynchosia nolubilis提取物的材料。 组合物含有0.001-40％的松柏提取物。 组合物含有0.001-50％的Rhynchosia nolubilis提取物。 提取物以0.1-10:1的重量比混合。 该组合物用于抗皱和抗老化，而没有副作用如光敏化。 （AA）小豆提取物（ppm）; （BB）松针提取物（ppm）; （CC）松针混合物：小梁= 1：1（ppm）
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公开(公告)号：KR1020120116695A
公开(公告)日：2012-10-23
申请号：KR1020110034299
申请日：2011-04-13
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/37 , G01N33/502 , G01N2333/8146 , G01N2500/10
Abstract: PURPOSE: An inflammatory anti-wrinkle material screening method is provided to accurately screen the inflammatory anti-wrinkle materials and to screen anti-wrinkle materials which are highly related to bio-correlation. CONSTITUTION: An inflammatory anti-wrinkle material screening method comprises the following steps: processing inflammation stimulus for immunocytes; processing testing materials on skin cells; processing the immunocytes; and measuring the matrix metalloproteinase-1 concentration of the skin cells processed with immunocytes. The immunocytes includes THP-1 cell(Human acute monocytic leukemia cells). The skin cell includes normal human fibroblast(NHF). The inflammation stimulus includes 0.001~20 micro M of LPS(Lipopolysaccharide) and 1-2000 UNITs of INF- γ(Interferon-γ). The LPS includes Escherichia coli originated LPS. [Reference numerals] (AA) TNF-alpha analyzation; (BB) Control group
Abstract translation: 目的：提供一种抗炎抗皱材料筛选方法，准确筛选炎症性抗皱材料，并筛选与生物相关性高度相关的抗皱材料。 构成：炎症抗皱材料筛选方法包括以下步骤：处理免疫细胞的炎症刺激; 加工皮肤细胞检测材料; 加工免疫细胞; 并测量用免疫细胞处理的皮肤细胞的基质金属蛋白酶-1浓度。 免疫细胞包括THP-1细胞（人类急性单核细胞白血病细胞）。 皮肤细胞包括正常人成纤维细胞（NHF）。 炎症刺激包括0.001〜20微摩尔的LPS（脂多糖）和1-2000单位的INF-γ（干扰素-γ）。 LPS包括大肠杆菌起始的LPS。 （参考号）（AA）TNF-α分析; （BB）对照组
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公开(公告)号：KR1020120103774A
公开(公告)日：2012-09-20
申请号：KR1020110020600
申请日：2011-03-08
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/02 , C12N1/20 , C12N1/36 , G01N33/5044 , G01N33/6863 , G01N2333/52
Abstract: PURPOSE: A method for pre-treating bacteria for screening an anti-inflammatory agent in oral cavity is provided to prevent protein denaturation of oral bacteria and to maintain antigenicity of the oral bacteria. CONSTITUTION: A method for pre-treating bacteia for screenign an anti-inflammatory agent in oral cavity comprises: a step of heating the oral bacteria at 80-120 Deg. C.; and a step of freezing the oral bacteria at -90 Deg. C. to -50 Deg. C. The oral bacteria contain anaerobic bacteria. The oral bacteria include Fusobacterium nucleatum, Prevotellaintermedia, Capnocyto phagagingivalis, Actinomyces viscosus, Actinomyces naeslundii, Actinomyces israelii, Streptococcus sanguis, Streptococcus mitis, Treponemapallidum, Porphyromonasgingivalis, or Treponema denticola. [Reference numerals] (AA) Spot intensity(AU/mm^2); (BB) Control group; (CC) 0.1% of oral bacteria
Abstract translation: 目的：提供一种预处理细菌用于口腔抗炎药物筛选的方法，以防止口腔细菌的蛋白质变性并维持口腔细菌的抗原性。 构成：用于预处理口腔灭菌剂的细菌的方法包括：将口腔细菌加热至80-120度的步骤。 C。; 以及在-90度下冷冻口腔细菌的步骤。 C.至-50度 C.口腔细菌含有厌氧菌。 口腔细菌包括核细胞杆菌，Prevotellaintermedia，吞噬细胞嗜血杆菌，放线杆菌，放线杆菌，以色列放线菌，血链球菌，Treponemapallidum，Porphyromonasgingivalis或Treponema denticola。 [参考数字]（AA）光斑强度（AU / mm ^ 2）; （BB）对照组; （CC）0.1％口服细菌
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公开(公告)号：KR101096409B1
公开(公告)日：2011-12-21
申请号：KR1020050086765
申请日：2005-09-16
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 모아레 이미지(moire image)를 이용한 피부탄력 측정방법에 관한 것으로서, 피험자 피부의 모아레 이미지를 촬영하는 단계, 상기 촬영된 모아레 이미지에서 나타난 등고선의 간격을 계산하거나 등고선의 각도를 측정하는 단계; 상기 간격 또는 각도로부터 피부탄력지수를 산출하는 단계를 포함하는 피부 탄력 측정방법을 제공한다.
모아레, 피부, 탄력, 등고선-
Patent Agency Ranking
公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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公开(公告)号：KR101874790B1
公开(公告)日：2018-07-05
申请号：KR1020110122623
申请日：2011-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: C12N5/0698 , A61F2/10 , A61L27/24 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60
Abstract: 본발명은섬유아세포, 각질형성세포및 멜라닌형성세포를함유하는인공피부에관한것으로, 멜라닌형성세포를함유함으로써피부연구에대하여자극, 미백및 노화와같은다양한영역의연구를동시에행할수 있는인공피부모델을제공할수 있다. 또한본 발명의인공피부는진피층을 2 이상의층을포함하는것을특징으로하는인공피부를제공하여진피수축현상으로인한조직학적변형이적어생리적부작용이없으며, 인체상관성이높은인공피부모델을제공할수 있다.
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公开(公告)号：KR1020130056957A
公开(公告)日：2013-05-31
申请号：KR1020110122624
申请日：2011-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61L27/24 , A61F2/105 , A61L27/3804 , A61L27/60
Abstract: PURPOSE: A measuring method of a skin regeneration effect using a skin equivalent is provided to directly evaluate a skin regeneration effect of a material by performing a wound treatment analysis using a punch biopsy. CONSTITUTION: A dermis layer of a skin regeneration comprises an inside dermis layer and an outside dermis layer. The inside dermis layer comprises a collagen and a fibroblast. The outside dermis layer comprises a collagen. The skin equivalent suppresses a contraction of the dermis. A measuring method of a skin regeneration effect comprises the following steps: a step of making a wound in a epidermis layer of a skin equivalent; a step in which a testing material is processed in a generated wound for 5-10 days; and a step of observing an epimorphic regeneration state of the skin equivalent with time with performing H&E stain(Hematoxylin and Eosin stain) at 2-3 days intervals after processing the testing material. [Reference numerals] (AA) Epidermis layer; (BB) Damaged portion of epidermis; (CC) Dermis layer
Abstract translation: 目的：提供使用皮肤当量的皮肤再生效果的测定方法，通过使用穿孔活检进行伤口处理分析，直接评价材料的皮肤再生效果。 构成：皮肤再生的真皮层包括真皮内层和外层真皮层。 内层真皮层包含胶原和成纤维细胞。 外部真皮层包含胶原蛋白。 皮肤等效抑制真皮的收缩。 皮肤再生效果的测定方法包括以下步骤：在皮肤表皮等级制作伤口的步骤; 将测试材料在产生的伤口中加工5-10天的步骤; 以及在处理测试材料之后以2-3天间隔观察皮肤相当于皮肤异化再生状态的步骤，每隔2-3天进行H＆E染色（苏木精和伊红染色）。 （AA）表皮层; （BB）表皮损伤部位; （CC）真皮层
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公开(公告)号：KR101134890B1
公开(公告)日：2012-04-13
申请号：KR1020090073295
申请日：2009-08-10
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A23L2/52 , A23L2/60 , A23L33/10 , A23L33/105 , A23L33/15 , A23L33/21 , A61K2800/522 , A61K2800/85 , A61Q19/02
Abstract: 막걸리 농축액을 유효성분으로 함유하는 조성물이 개시된다. 상기 조성물은, 항산화 및 미백 효과를 나타내며, 이를 통해 화장품, 건강식품 또는 의약 분야에서 다양하게 활용 가능하다.
막걸리, 탁주, 농축액, 항산화, 미백, 화장료-
公开(公告)号：KR100768071B1
公开(公告)日：2007-10-17
申请号：KR1020040037370
申请日：2004-05-25
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 피부에서의 혈액순환을 촉진시키는 성분을 고농도로 함유한 한방 생약재의 초임계 추출물('활음진(活陰眞)'이라 명명한다) 및 이를 함유하는 피부 외용제 조성물에 관한 것이다. 더욱 상세하게는, 산사자, 당귀, 홍화, 두충, 숙지황을 0.5~2:0.5~1:0.5~1:0.5~2:0.5~1의 중량비로 초임계 추출하여 얻은 복합 생약 성분인 활음진 및 이를 함유함으로써 피부 혈액순환을 촉진할 뿐만 아니라 피부의 노화 방지 및 지연 효과를 지니는 피부 외용제 조성물에 관한 것이다.
활음진(活陰眞)*산사자*당귀*홍화*두충*숙지황*초임계추출*클로로젠산*항산화*피부 노화 방지*외용제 조성물
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