公开(公告)号：KR1020130001123A

公开(公告)日：2013-01-03

申请号：KR1020120061988

申请日：2012-06-11

Applicant: (주)아모레퍼시픽

Inventor： 김규한 ,  최현정 ,  빈범호 ,  이태룡

IPC: C12N15/113 ,  A61K8/00 ,  A61Q19/02 ,  A61Q7/00

CPC classification number: C12N15/1137 ,  A61K8/606 ,  A61K31/7105 ,  A61K2800/78 ,  A61K2800/782 ,  A61Q5/10 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  G01N33/5023

Abstract: PURPOSE: A composition containing miRNA or an antisense molecule of the miRNA is provided to regulate tyrosinase mRNA expression and pigmentation and to enhance skin whitening effect. CONSTITUTION: A composition for regulating pigmentation and expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among sequences of sequence number 1 and is also selected among oligonucleotide molecules containing 22 continuous bases with CCCUGAG. The pigmentation-related gene is tyrosinase mRNA. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for regulating pigmentation and expression of a pigmentation-related gene contains a base sequence which is complementary to miRNA of sequence number and an antisense nucleic acid molecule of sequence number 2, which is hybridizable with the miRNA. [Reference numerals] (AA) Relative mRNA expression of TYR/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) MiR-125b derivatives

Abstract translation: 目的：提供含有miRNA或miRNA的反义分子的组合物，以调节酪氨酸酶mRNA表达和色素沉着，并增强皮肤美白效果。 构成：用于调节色素沉着相关基因的色素沉着和表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的序列，也选自含有CCCUGAG的22个连续碱基的寡核苷酸分子。 色素沉着相关基因是酪氨酸酶mRNA。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于调节色素沉着相关基因的色素沉着和表达的组合物含有与序列号的miRNA互补的碱基序列和与miRNA杂交的序列号2的反义核酸分子。 （AA）相对mRNA表达TYR / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）MiR-125b衍生物