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公开(公告)号：KR1020150064573A
公开(公告)日：2015-06-11
申请号：KR1020130149424
申请日：2013-12-03
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6883 , C12N15/11 , C12Q2600/158
Abstract: 본발명의태양광차단기능측정방법에따르면, 태양광조사에따른피부세포내 유전자발현량을비교함으로써정확하고객관적으로태양광차단기능성물질스크리닝하거나, 태양광차단효능을평가할수 있다. 또한, 본발명에따른방법은케라틴 10(Keratin 10), 케라틴 1(Keratin 1), 필라그린(Filaggrin) 및트랜스글루타미나아제 3(Transglutaminase 3)를이용함으로써가시광선중 가장피부손상을가장많이유도하는 400∼500 nm 파장의블루/바이올렛라이트의차단여부까지판별할수 있으므로, 보다세분화된태양광차단기능측정결과를제공할수 있다.
Abstract translation: 根据本发明，用于测量阳光保护功能的方法可以精确地屏蔽阳光保护功能材料，并且可以通过根据阳光的照射比较皮肤细胞中的基因表达比来评估阳光保护的效果。 此外，该方法可以区分是否阻挡400-500nm波长的蓝色/紫色光，通过使用角蛋白10，角蛋白1，丝聚蛋白和转谷氨酰胺酶3，最多可以诱发可见光线中的皮肤损伤，从而提供亚专利结果 测量阳光保护功能。
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公开(公告)号：KR1020130051353A
公开(公告)日：2013-05-20
申请号：KR1020110116647
申请日：2011-11-09
Applicant: (주)아모레퍼시픽
IPC: G01N33/68 , G01N33/15 , G01N33/53 , C12N15/115
Abstract: PURPOSE: A method for screening a material which regulates skin pigmentation is provided to screen a material for regulating skin pigmentation, and to effectively treat hyperpigmentation or hypopigmentation by regulating intracellular and intercellular signal transduction faction and transcription factor. CONSTITUTION: A method for screening a material which regulates skin pigmentation comprises: a step of treating one or more gene selected from the group consisting of IFN gamma, IL4, IL17, IL6, STAT3, STAT6, JAK1, JAK2, and JAK3 with a candidate material; and a step of selecting a candidate material which enhances or reduces gene expression as a material which regulates skin pigmentation. A candidate material which enhances gene expression is selected as a useful material which possibly suppresses pigmentation. A candidate material which reduces gene expression is selected as a useful material which possibly enhances skin pigmentation. [Reference numerals] (AA) Comparative example; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract translation: 目的：提供一种筛选调节皮肤色素沉着的材料的方法，筛选调节皮肤色素沉着的材料，并通过调节细胞内和细胞间信号转导系和转录因子有效治疗色素沉着过度或色素沉着不足。 构成：筛选调节皮肤色素沉着的材料的方法包括：用候选物质治疗选自IFNγ，IL4，IL17，IL6，STAT3，STAT6，JAK1，JAK2和JAK3的一种或多种基因的步骤 材料; 以及选择增强或降低基因表达作为调节皮肤色素沉着的材料的候选物质的步骤。 选择增强基因表达的候选物质作为可能抑制色素沉着的有用材料。 选择减少基因表达的候选物质作为可能增强皮肤色素沉着的有用材料。 （附图标记）（AA）比较例; （BB）实施例1; （CC）实施例2; （DD）实施例3
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公开(公告)号：KR1020110116370A
公开(公告)日：2011-10-26
申请号：KR1020100035746
申请日：2010-04-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/28 , A61K8/97 , A61Q19/005 , A61Q19/007
Abstract: 본 발명은 블루메아 발사미페라 추출물을 유효 성분으로 포함하는 피부 가려움 완화 및 억제, 피부 보습, 피부 염증 완화 및 억제, 피부 면역성 증가, 피부 과민 반응 개선 또는 아토피 피부 개선 및 치료용 조성물을 개시한다.
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公开(公告)号：KR1020170091567A
公开(公告)日：2017-08-09
申请号：KR1020170097086
申请日：2017-07-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/75 , A61K8/97 , A61Q19/005 , A61Q19/007
Abstract: 본발명은무라야패니쿨라타추출물을유효성분으로포함하는피부가려움증완화및 억제, 피부보습, 피부염증완화및 억제, 피부면역성강화, 피부과민반응개선또는아토피피부개선및 치료용조성물을개시한다.
Abstract translation: 本发明公开了一种村的同伴库拉其他皮肤瘙痒缓解包括提取物作为活性成分和抑制，皮肤保湿剂，皮肤炎症和抑制，皮肤免疫增强，皮肤致敏改善或特应性皮肤改善和治疗组合物。
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公开(公告)号：KR101559068B1
公开(公告)日：2015-10-20
申请号：KR1020080083683
申请日：2008-08-27
Applicant: (주)아모레퍼시픽
Abstract: 본발명은지방세포분화와성장을억제하는키메린(Chemerin, TIG2, RARRES2) 또는키메린의발현을조절하는사이토카인을유효성분으로하는지방세포분화또는성장억제용조성물관한것이다. 구체적으로본 발명은상기키메린을유효성분으로하는약학조성물, 건강식품조성물및 화장료조성물로서비만증, 지방종(lipoma), 동맥경화증, 당뇨병, 고혈압, 고지혈증, 고콜레스테롤혈증, 과식증, 순환기계질환또는허혈성심질환을예방또는치료에유용할뿐만아니라, 미용또는성형목적의지방조직감소에유용하게적용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020130132508A
公开(公告)日：2013-12-04
申请号：KR1020137016899
申请日：2011-01-03
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/00 , A61K8/97 , A61K36/58 , A61K36/62 , A61K2300/00
Abstract: The present invention relates to a composition for combating oxidation and alleviating detrimental effects on skin caused by yellow sand including a Meliae Cortex extract and a lotus flower extract, and more specifically, the present invention includes a Meliae Cortex extract and a lotus flower extract, detoxicates and discharges a toxin by increasing the expression of NQO1 which is an enzyme for detoxicating a toxin and GSTT1 which is an enzyme for discharging a toxin, protects the skin by increasing the expression of antimicrobial peptide hBD3 which is a natural immune factor, and protects the skin and suppresses aging by suppressing the generation of active oxygen by increasing the expression of anti-oxidizing protein of GPX1, catalase, Trx1, and Prdx1.
Abstract translation: 本发明涉及一种用于抵抗氧化并减轻由黄砂（包括堇菜皮提取物和莲花提取物）引起的对皮肤的有害影响的组合物，更具体地说，本发明包括Meliae Cortex提取物和莲花提取物，解毒 并通过增加作为毒素解毒酶的NQO1的表达和作为排出毒素的酶的GSTT1的表达来释放毒素，通过增加作为天然免疫因子的抗微生物肽hBD3的表达来保护皮肤，并保护 通过增加GPX1，过氧化氢酶，Trx1和Prdx1的抗氧化蛋白的表达来抑制活性氧的产生来抑制老化。
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公开(公告)号：KR101309335B1
公开(公告)日：2013-09-16
申请号：KR1020110064247
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/16 , A61K31/7105 , A61P17/00
Abstract: 본 발명은 miRNA-526b 기능의 저해제(inhibitor)로 작용하는 올리고뉴클레오티드 또는 모방체(mimic)로 작용하는 올리고뉴클레오티드를 포함하는 콜라겐 조절용 조성물을 제공한다. 본 발명의 조성물은 콜라겐 분해효소(collagenase) 중의 하나인 MMP1(matrix metalloproteinase 1)의 발현을 조절하여 진피층을 채우는 콜라겐 생성을 조절하므로 노화 개선, 예방 또는 치료에 사용될 수 있다.
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公开(公告)号：KR101129755B1
公开(公告)日：2012-03-23
申请号：KR1020090113295
申请日：2009-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q17/04 , A61K8/37 , A61K8/4946
Abstract: 본 발명은 옥틸 살리실레이트 및 페닐벤즈이미다졸 설포닉산으로 이루어진 군에서 선택되는 하나 이상을 유효성분으로 포함하는 자외선 C(UVC, ultraviolet C) 차단용 조성물에 관한 것이다.
자외선, UVA, UVB, UVC, 화장료 조성물-
公开(公告)号：KR1020120026689A
公开(公告)日：2012-03-20
申请号：KR1020100088716
申请日：2010-09-10
Applicant: (주)아모레퍼시픽
IPC: A61K36/282 , A61K8/97 , C12N5/077 , A61Q19/08
CPC classification number: A61K36/282 , A61K8/97 , A61K2800/86 , A61Q19/08 , C12N5/0669 , C12N2506/1353
Abstract: PURPOSE: A composition for promoting human mesenchymal stem cell differentiation is provided to enhance skin volume and elasticity and to improve anti-wrinkling. CONSTITUTION: An external use skin composition for promoting adipocytes contains 0.0001-30 wt% of Artemisia asiatica extract as an active ingredient. The composition promotes differentiation of mesenchymal stem cells into adipocytes. The mesenchymal stem cells are derived from human body. A pharmaceutical composition for promoting differentiation into adipocytes contains the extract as an active ingredient. The dose of the extract is 0.001 mg/kg/day-2,000 mg/kg/day.
Abstract translation: 目的：提供促进人间质干细胞分化的组合物，以增强皮肤体积和弹性，并改善抗皱纹。 构成：用于促进脂肪细胞的外用皮肤组合物含有0.0001-30重量％的亚洲艾蒿提取物作为活性成分。 该组合物促进间充质干细胞分化为脂肪细胞。 间充质干细胞来源于人体。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。 提取物的剂量为0.001mg / kg /天-2000mg / kg /天。
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公开(公告)号：KR1020120009183A
公开(公告)日：2012-02-01
申请号：KR1020100071135
申请日：2010-07-23
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition containing Potulacae Grandiflorae Herba extract is provided to promote differentiation of human mesenchymal stem cells into adipocytes. CONSTITUTION: An external use skin composition for promoting differentiation of human mesenchymal stem cells into adipocytes contains 0.0001-30 wt% of Potulacae Grandiflorae Herba extract as an active ingredient. A pharmaceutical composition for promoting the differentiation contains the Potulacae Grandiflorae Herba extract as an active ingredient. The dose of the Potulacae Grandiflorae Herba extract is 0.001mg/kg-2000mg/kg per day.
Abstract translation: 目的：提供含有甘草提取物的组合物，以促进人间充质干细胞分化为脂肪细胞。 构成：用于促进人类间充质干细胞分化为脂肪细胞的外用皮肤组合物含有0.0001-30重量％的Pot草提取物作为活性成分。 用于促进分化的药物组合物含有大戟草作为活性成分。 Pot草提取物的剂量为0.001mg / kg-2000mg / kg /天。
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