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公开(公告)号：KR101663971B1
公开(公告)日：2016-10-12
申请号：KR1020100037969
申请日：2010-04-23
Applicant: (주)아모레퍼시픽
IPC: A61K36/185 , A61K8/97 , A61K9/00 , C12N5/0775
Abstract: 본발명은인간중간엽줄기세포의지방세포로의분화를촉진하는조성물에관한것으로, 보다상세하게는미후도및 미후등추출물중 적어도 1종이상을유효성분으로함유하여인간중간엽줄기세포를지방세포로분화하는것을촉진시킴으로써지방체(Lipid droplet)를생성하여피부의볼륨과탄력을증진시키고주름을개선시키는조성물에관한것이다.
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公开(公告)号：KR101637973B1
公开(公告)日：2016-07-11
申请号：KR1020137016899
申请日：2011-01-03
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/00 , A61K8/97 , A61K36/58 , A61K36/62 , A61K2300/00
Abstract: 본발명은새로운피부자극완화제로서고련피및 연꽃잎추출물을함유하는항산화용및 황사에의한피부유해영향완화용조성물에관한것이다. 구체적으로, 본발명은고련피및 연꽃잎추출물을함유하여, 독소를해독하는효소인 NQO1, 독소를배출하는효소인 GSTT1의발현을증가시켜독소를해독및 배출하고, 자연면역인자인피부항균펩타이드 hBD3의발현을증가시켜피부를보호하며, GPX1, 카탈라아제(catalase), Trx1, Prdx1의항산화단백질의발현을증가시켜활성산소의생성을억제함으로써피부보호및 노화억제의효과를갖는다.
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公开(公告)号：KR1020120002482A
公开(公告)日：2012-01-05
申请号：KR1020110064247
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/16 , A61K31/7105 , A61P17/00
CPC classification number: A61K31/7105 , A61K8/64 , A61K31/7115 , A61K38/005 , A61K48/005 , A61Q19/08
Abstract: PURPOSE: A composition containing an oligonucleotide or mimic acting as an inhibitor of miRNA-526b is provided to control collagen generation and to prevent or treat aging. CONSTITUTION: A composition for controlling collagen contains 15-23 serial nucleotides of sequence number 1. The collagen is controlled by regulating the expression of matrix metalloproteinase 1(MMP1). The oligonucleotide reduces or suppresses the expression of MMP1 by hybridization with MMP1 mRNA. The composition is used for anti-aging.
Abstract translation: 目的：提供含有作为miRNA-526b抑制剂的寡核苷酸或模拟物的组合物，以控制胶原蛋白的产生和预防或治疗老化。 构成：用于控制胶原的组合物含有序列1的15-23个连续核苷酸。通过调节基质金属蛋白酶1（MMP1）的表达来控制胶原蛋白。 寡核苷酸通过与MMP1 mRNA杂交降低或抑制MMP1的表达。 该组合物用于抗衰老。
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24.发明公开꽃가루, 집먼지 진드기 또는 황사에 의한 피부 유해반응을 스크리닝하는 방법 및 이를 조절하는 피부 외용제 조성물 有权用于通过花粉，房尘螨或黄锈砂筛选皮肤有害反应的方法，以及用于控制反应的皮肤外部应用的组合物
公开(公告)号：KR1020100060752A
公开(公告)日：2010-06-07
申请号：KR1020080119483
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
CPC classification number: G01N33/5023 , A61K36/58 , C12Q1/6844 , C12Q2600/136 , G01N33/15
Abstract: PURPOSE: A method for screening a material which relieves skin irritation by environmental harmful factor is provided to manufacture an external use formulation and to detoxify. CONSTITUTION: A method for screening a material which relieves skin irritation by environmental harmful factor comprises: a step of treating candidates which regulates intracellular factor in vitro; a step of treating the environmental harmful factor to test cells to induce overexpression of the factor; and a step of measuring expression level. The test cells are keratinocytes. The environmental harmful factor is pollen or yellow sand. The overexpressed factor is interleukin 6 or 8, GSTT1, NQ01, or hBD3. The screened material is Melia azedarach L. var. japonica Makino or Tussilago farfara L. extract.
Abstract translation: 目的：提供一种用于筛选由环境有害因素减轻皮肤刺激的物质的方法，以制造外用制剂和解毒。 构成：通过环境有害因子筛选缓解皮肤刺激的材料的方法包括：处理体外调节细胞因子的候选物的步骤; 治疗环境有害因素以测试细胞以诱导因子过表达的步骤; 以及测量表达水平的步骤。 测试细胞是角质形成细胞。 环境有害因素是花粉或黄沙。 过表达因子是白细胞介素6或8，GSTT1，NQ01或hBD3。 筛选的材料是Melia azedarach L. var。 粳稻或东方龙草L.提取物。
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公开(公告)号：KR1020100056239A
公开(公告)日：2010-05-27
申请号：KR1020080115315
申请日：2008-11-19
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A cosmetic composition containing polysaccharides for adsorbing heavy metal and micro dust is provided to reduce skin inflammation caused by heavy metal and micro dust, and to prevent skin trouble. CONSTITUTION: A cosmetic composition for adsorbing heavy metal and micro dust contains 0.01-20.0 weight% of Schizopyllum commune, seaweed, and ginseng polysaccharides as active ingredient. The Schizopyllum commune polysaccharide is beta-1,3-glucan. The seaweed polysaccharide is Laminaria digitata polysaccharide. A method for producing the polysaccharides comprises: a step of culturing mycelium of Schizopyllum commune, seaweed, or ginseng; a step of extracting with water to obtain water soluble fraction; a step of freeze-drying and extracting with methanol to obtain methanol insoluble fraction; a step of extracting with ethanol to obtain ethanol insoluble fraction; and a step of eluting by column chromatography.
Abstract translation: 目的：提供含有重金属和微粉尘多糖的化妆品组合物，以减少重金属和微尘引起的皮肤炎症，防止皮肤发生麻烦。 构成：用于吸附重金属和微尘的化妆品组合物含有0.01-20.0重量％的裂殖酵母，海藻和人参多糖作为活性成分。 裂殖酵母多糖是β-1,3-葡聚糖。 海藻多糖是层状多糖。 制备多糖的方法包括：培养裂殖酵母菌丝，海藻或人参的菌丝体的步骤; 用水萃取得到水溶性成分的步骤; 用甲醇进行冷冻干燥萃取，得到不溶于甲醇的级分; 用乙醇萃取得到乙醇不溶级分的步骤; 和通过柱色谱法洗脱的步骤。
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Patent Agency Ranking
公开(公告)号：KR101904918B1
公开(公告)日：2018-10-08
申请号：KR1020110116647
申请日：2011-11-09
Applicant: (주)아모레퍼시픽
Abstract: 본발명은피부색소침착조절물질을스크리닝하는방법에관한것이다. 본명세서에기재된기술을이용하면, 피부에유용한피부색소침착조절용물질을스크리닝할수 있다. 또한, 본발명의세포간, 세포내 신호전달인자및 전사인자를조절함으로써, 피부멜라닌양의감소또는증가에의하여발생하는저색소증또는과색소침착증등의질환을효과적으로개선할수 있다. 즉, 자외선에의한피부흑화뿐만아니라, 아토피나건선에의한 2차적인피부저색소증및 색소이상증, 피부염증이관여한다고알려져있는기미, 점(nevi), 흑자, 검버섯과같은피부과색소침착증, 백반증또는백모와같은색소결여증에유용한물질을스크리닝할수 있고그 스크리닝된 물질을사용하여상기증상들을개선, 치료할수 있다.
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公开(公告)号：KR1020150064573A
公开(公告)日：2015-06-11
申请号：KR1020130149424
申请日：2013-12-03
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6883 , C12N15/11 , C12Q2600/158
Abstract: 본발명의태양광차단기능측정방법에따르면, 태양광조사에따른피부세포내 유전자발현량을비교함으로써정확하고객관적으로태양광차단기능성물질스크리닝하거나, 태양광차단효능을평가할수 있다. 또한, 본발명에따른방법은케라틴 10(Keratin 10), 케라틴 1(Keratin 1), 필라그린(Filaggrin) 및트랜스글루타미나아제 3(Transglutaminase 3)를이용함으로써가시광선중 가장피부손상을가장많이유도하는 400∼500 nm 파장의블루/바이올렛라이트의차단여부까지판별할수 있으므로, 보다세분화된태양광차단기능측정결과를제공할수 있다.
Abstract translation: 根据本发明，用于测量阳光保护功能的方法可以精确地屏蔽阳光保护功能材料，并且可以通过根据阳光的照射比较皮肤细胞中的基因表达比来评估阳光保护的效果。 此外，该方法可以区分是否阻挡400-500nm波长的蓝色/紫色光，通过使用角蛋白10，角蛋白1，丝聚蛋白和转谷氨酰胺酶3，最多可以诱发可见光线中的皮肤损伤，从而提供亚专利结果 测量阳光保护功能。
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公开(公告)号：KR1020130051353A
公开(公告)日：2013-05-20
申请号：KR1020110116647
申请日：2011-11-09
Applicant: (주)아모레퍼시픽
IPC: G01N33/68 , G01N33/15 , G01N33/53 , C12N15/115
Abstract: PURPOSE: A method for screening a material which regulates skin pigmentation is provided to screen a material for regulating skin pigmentation, and to effectively treat hyperpigmentation or hypopigmentation by regulating intracellular and intercellular signal transduction faction and transcription factor. CONSTITUTION: A method for screening a material which regulates skin pigmentation comprises: a step of treating one or more gene selected from the group consisting of IFN gamma, IL4, IL17, IL6, STAT3, STAT6, JAK1, JAK2, and JAK3 with a candidate material; and a step of selecting a candidate material which enhances or reduces gene expression as a material which regulates skin pigmentation. A candidate material which enhances gene expression is selected as a useful material which possibly suppresses pigmentation. A candidate material which reduces gene expression is selected as a useful material which possibly enhances skin pigmentation. [Reference numerals] (AA) Comparative example; (BB) Example 1; (CC) Example 2; (DD) Example 3
Abstract translation: 目的：提供一种筛选调节皮肤色素沉着的材料的方法，筛选调节皮肤色素沉着的材料，并通过调节细胞内和细胞间信号转导系和转录因子有效治疗色素沉着过度或色素沉着不足。 构成：筛选调节皮肤色素沉着的材料的方法包括：用候选物质治疗选自IFNγ，IL4，IL17，IL6，STAT3，STAT6，JAK1，JAK2和JAK3的一种或多种基因的步骤 材料; 以及选择增强或降低基因表达作为调节皮肤色素沉着的材料的候选物质的步骤。 选择增强基因表达的候选物质作为可能抑制色素沉着的有用材料。 选择减少基因表达的候选物质作为可能增强皮肤色素沉着的有用材料。 （附图标记）（AA）比较例; （BB）实施例1; （CC）实施例2; （DD）实施例3
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公开(公告)号：KR1020110116370A
公开(公告)日：2011-10-26
申请号：KR1020100035746
申请日：2010-04-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/28 , A61K8/97 , A61Q19/005 , A61Q19/007
Abstract: 본 발명은 블루메아 발사미페라 추출물을 유효 성분으로 포함하는 피부 가려움 완화 및 억제, 피부 보습, 피부 염증 완화 및 억제, 피부 면역성 증가, 피부 과민 반응 개선 또는 아토피 피부 개선 및 치료용 조성물을 개시한다.
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公开(公告)号：KR1020170091567A
公开(公告)日：2017-08-09
申请号：KR1020170097086
申请日：2017-07-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/75 , A61K8/97 , A61Q19/005 , A61Q19/007
Abstract: 본발명은무라야패니쿨라타추출물을유효성분으로포함하는피부가려움증완화및 억제, 피부보습, 피부염증완화및 억제, 피부면역성강화, 피부과민반응개선또는아토피피부개선및 치료용조성물을개시한다.
Abstract translation: 本发明公开了一种村的同伴库拉其他皮肤瘙痒缓解包括提取物作为活性成分和抑制，皮肤保湿剂，皮肤炎症和抑制，皮肤免疫增强，皮肤致敏改善或特应性皮肤改善和治疗组合物。
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