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公开(公告)号：KR1020080029342A
公开(公告)日：2008-04-03
申请号：KR1020060095279
申请日：2006-09-29
Applicant: (주)아모레퍼시픽
IPC: C07C233/11 , C07C233/21
Abstract: A retinoic acid derivative is provided to exhibit a collagen production effect and a collagenase expression inhibition effect and cause less skin irritation. A method for preparing a retinoic acid derivative includes the steps of: (i) reacting retinoic acid with alkylchloroformate to prepare an anhydride compound represented by the following formula 2; and (ii) reacting the prepared anhydride compound with an amine hydrochloride represented by the following formula 3 to prepare the retinoic acid derivative represented by the following formula 1. In the formulae, R1 is hydrogen, linear or branched C1-7 alkyl or C3-7 cycloalkyl, R2 is hydroxyl, linear or branched C1-7 alkyl substituted by 1-4 hydroxyl groups, or linear branched C1-5 alkyl substituted by hydroxy pyranone, and R3 is C1-7 alkyl.
Abstract translation: 提供视黄酸衍生物以表现出胶原产生效果和胶原酶表达抑制作用，并且引起较少的皮肤刺激。 视黄酸衍生物的制备方法包括以下步骤：（i）使视黄酸与氯甲酸烷基酯反应，制备下式2表示的酸酐化合物; 和（ii）使所制备的酸酐化合物与由下式3表示的胺盐酸盐反应以制备由下式1表示的视黄酸衍生物。在式中，R 1是氢，直链或支链C 1-7烷基或C 3- 7环烷基，R2是羟基，被1-4个羟基取代的直链或支链C 1-7烷基，或被羟基吡喃酮取代的直链支链C 1-5烷基，R 3是C 1-7烷基。
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公开(公告)号：KR1020150139298A
公开(公告)日：2015-12-11
申请号：KR1020140067729
申请日：2014-06-03
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K8/99 , A61Q19/00 , A61K36/8988 , A61Q19/08
CPC classification number: A61K8/97 , A61K2800/74 , A61K2800/85 , A61Q19/007 , A61K8/99 , A61K36/8988 , A61K2800/70 , A61Q19/08
Abstract: 본발명은홍국추출물을함유하는피부외용제조성물에관한것으로서, 보다상세하게는홍국의추출물을함유함으로써각질형성세포에서로리크린(loricrin)의생성을증가시켜각질형성을돕고, 이로인하여피부장벽기능을강화시킴으로써우수한피부보습력개선효과를제공할수 있는피부외용제조성물에관한것이다.
Abstract translation: 本发明涉及含有红酵母提取物的皮肤外用剂组合物，更具体地说，涉及含有红酵母提取物的皮肤外用组合物，增加角质形成细胞中的氯霉素的产生 从而有助于形成死皮细胞。 此外，本发明的组合物由于这些优点而增强皮肤屏障功能，从而提供改善皮肤保湿效果的优异效果。
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