천우슬을 이용한 관절염 치료제
    25.
    发明公开
    천우슬을 이용한 관절염 치료제 有权
    抗精神病药物使用CYATHULA OFFICINALIS

    公开(公告)号:KR1020100132172A

    公开(公告)日:2010-12-17

    申请号:KR1020090050850

    申请日:2009-06-09

    Inventor: 김현표 권용수

    CPC classification number: A61K36/21 A23L33/105 A61K31/365

    Abstract: PURPOSE: A composition containing Cyathula officinalis extract, fraction or sesquiterpene derivative isolated from the same is provided to suppress MMP-13 expression and to prevent and treat arthritis. CONSTITUTION: A pharmaceutical composition for preventing and treating diseases caused by MMP-13 overexpression contains Cyathula officinalis extract, fraction or sesquiterpene derivative isolated from the same as an active ingredient. The sesquiterpene derivative is 5alpha-H-10-beta-selina-4(14),7(11)-dien-8-one of structural formula I or atractylenoide I of structural formula II. The Cyathula officinalis extract is isolated using ethyl acetate, low alcohol of C1-C4, hexane, chloroform, methylene chloride, ethylacetate, glycerin, butylene glycol or mixture solvent thereof. The Cyathula officinalis fraction is a polar solvent soluble fraction or non-polar solvent soluble fraction.

    Abstract translation: 目的:提供含有仙客来提取物,从其分离的级分或倍半萜衍生物的组合物以抑制MMP-13的表达并预防和治疗关节炎。 构成:用于预防和治疗由MMP-13过表达引起的疾病的药物组合物含有与活性成分相同的仙contains提取物,级分或倍半萜衍生物。 倍半萜衍生物是结构式I的5α-H-10-β-selina-4(14),7(11) - 二酮-8-或结构式II的亚甲基降冰片烯I。 使用乙酸乙酯,低级醇C1-C4,己烷,氯仿,二氯甲烷,乙酸乙酯,甘油,丁二醇或其混合溶剂分离苦参提取物。 Cyathula officinalis级分是极性溶剂可溶性级分或非极性溶剂可溶级分。

Patent Agency Ranking