公开(公告)号：KR101424217B1

公开(公告)日：2014-08-13

申请号：KR1020110047026

申请日：2011-05-18

Applicant: 다이아텍코리아 주식회사 ,  학교법인 건국대학교

Inventor： 박형순 ,  강금용 ,  방주용 ,  정혜원

IPC: G01N33/15 ,  A61K38/43 ,  A61P27/02 ,  G01N33/68

Abstract: 본 발명은 노년 황반변성의 진단 및 치료를 위한 단백질 바이오마커에 관한 것이다.

公开(公告)号：KR101406755B1

公开(公告)日：2014-06-17

申请号：KR1020130078588

申请日：2013-07-04

Applicant: 다이아텍코리아 주식회사

Inventor： 박계신 ,  박형순 ,  조미연 ,  이은희 ,  김한나 ,  류정림

IPC: C07D491/22 ,  A61K31/409 ,  A61P35/00

Abstract: The present invention relates to chlorin lactone, a method for manufacturing the chlorin lactone, and a use of the same. More specifically, provided in the present invention is a new photosensitive agent for reducing a side effect by increasing a tumor selectivity and enabling an effective treatment by a laser. Provided in the present invention for achieving the purpose is chlorin lactone of the following chemical formula 1. The chlorin lactone of the present invention can be selected as a candidate substance for a new photosensitive agent.

Abstract translation: 本发明涉及二氢内酯，二氢内酯的制造方法及其用途。 更具体地，本发明提供了一种新的光敏剂，其通过增加肿瘤选择性并且能够通过激光进行有效的治疗来降低副作用。 在本发明中为了实现目的而提供的是以下化学式1的二氢in内酯。可以选择本发明的二氢in内酯作为新的感光剂的候选物质。

公开(公告)号：KR1020120073128A

公开(公告)日：2012-07-04

申请号：KR1020110140499

申请日：2011-12-22

Applicant: 건국대학교 산학협력단 ,  다이아텍코리아 주식회사

Inventor： 여운석 ,  박형순 ,  최인성 ,  강현욱

IPC: C07C321/08 ,  C07C315/06 ,  G01N30/72

Abstract: PURPOSE: An oligo(ethylene thiol) molecule substituted with deuterium and a manufacturing method thereof are provided to be used for mass analysis reference substance and to be applied in various fields. CONSTITUTION: A manufacturing method of an oligo(ethylene thiol) molecule substituted with deuterium comprises the following steps: a step of synthesizing 2-(2-(hex-5-enyloxy)ethoxy)ethanol or 2-(2-(undec-10-enyloxy)ethoxy)ethanol by reacting 6-bromohexene or 11-bromoundecene with NaOH solution and dithylene glycol mixed solution; a step of synthesizing 6-(2-(2-bromoethoxy)ethoxy)hex-1-ene or 11-(2-(2-bromo-ethoxy)ethoxy)undec-1-ene by reacting triphenyl phosphine and carbon tetrabromide with the product from the previous step; a step of synthesizing 2-(2-(2-(hex-5-enyloxy)ethoxy)ethoxy)ethanol-d4 or 2-(2-(2-(undec-10-enyloxy)ethoxy)ethoxy)ethanol-d4 by reacting NaH and ethylene glycol-D4 with the product from the previous step; a step of synthesizing S-6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)hexyl ethanethioate-d4 or S-11-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)undecyl ethanethioate by reacting thioacetic acid and 2,2'-azobis(2-methylpropionamidine)dihydrochloride with the product from the previous step; and a step of synthesizing 2-(2-(2-(6-mercaptohexyloxy)ethoxy)ethoxy) ethanol-d4 or 2-(2-(2-(11-mercaptoundecyloxy)ethoxy)ethoxy)ethanol by reacting HCl with the product from the previous step.

Abstract translation: 目的：用氘取代的低聚（乙烯硫醇）分子及其制造方法，用于质量分析参考物质，适用于各种领域。 构成：用氘取代的低聚（乙烯硫醇）分子的制造方法包括以下步骤：合成2-（2-（己-5-烯氧基）乙氧基）乙醇或2-（2-（十一碳-10-基） - 乙氧基）乙醇通过6-溴己烯或11-溴代癸酸与NaOH溶液和二亚乙基二醇混合溶液反应; 通过使三苯基膦和四溴化碳与四溴化碳反应合成6-（2-（2-（2-溴乙氧基）乙氧基）己-1-烯或11-（2-（2-溴 - 乙氧基）乙氧基）十一-1-烯） 产品从上一步; 乙氧基）乙氧基）乙氧基）乙醇-d4或2-（2-（2-（十一碳-10-烯氧基）乙氧基）乙氧基）乙醇-d4的步骤 将NaH和乙二醇-DD与前一步骤的产物反应; 合成S-6-（2-（2-（2-羟基乙氧基）乙氧基）乙氧基）乙基硫代乙酸酯-d4或S-11-（2-（2-（2-羟基乙氧基）乙氧基）乙氧基）十一烷基乙磺酸酯的步骤 将上述步骤中的产物与硫代乙酸和2,2'-偶氮双（2-甲基丙脒）二盐酸盐反应; 和通过HCl与产物反应合成2-（2-（2-（2-（6-巯基己氧基）乙氧基）乙氧基）乙醇-d4或2-（2-（2-（2-巯基十一烷氧基）乙氧基）乙氧基）乙醇）的步骤 从上一步。