-
-
-
-
-
公开(公告)号：KR1020120116082A
公开(公告)日：2012-10-22
申请号：KR1020110033611
申请日：2011-04-12
Applicant: 박사룡
Inventor： 박사룡
IPC: C07D401/12 , A61K31/444 , C07B55/00
Abstract: PURPOSE: A novel manufacturing method of optically active piperidine compounds is provided to recycle (R)-(4- chlorophenyl) 2 and to simply manufacture bepotastine at low cost. CONSTITUTION: A manufacturing method of (s)-4-(4-((4- chlorophenyl)((0001) 2- pyridyl) methoxy piperidino)butanoic acid) compound having a structural formula (I) comprises the following steps: reacting (R)-((4- chlorophenyl) -2- pyridyl) methanol having a structural formula (II) with the compound of the structural formula (II); and reacting a compound having the structural formula (III) with the compound having the structural formula (V). In the structural formula, R1 indicates methyl, ethyl, phenyl, or tolyl group, and R2 indicates hydrogen, lower alkyl having 2-4 carbons or - (CH2) n-COOR3. R3 indicates hydrogen, alkali metal, or the low alkyl group having 1-4 carbons. The compound of the structural formula (IV) is a useful intermediate compound for manufacturing the compound having the structural formula (I).
Abstract translation: 目的：提供光学活性哌啶化合物的新型制造方法，以循环（R） - （4-氯苯基）2并简单地以低成本制备贝他辛汀。 构成：具有结构式（I）的（S）-4-（4 - （（4-氯苯基）（（0001）2-吡啶基）甲氧基哌啶子基）丁酸）化合物的制备方法包括以下步骤： R） - 具有结构式（II）的（（4-氯苯基）-2-吡啶基）甲醇与结构式（II）的化合物反应; 并使具有结构式（III）的化合物与具有结构式（V）的化合物反应。 在结构式中，R 1表示甲基，乙基，苯基或甲苯基，R 2表示氢，具有2-4个碳原子的低级烷基或 - （CH 2）n -COOR 3。 R3表示氢，碱金属或具有1-4个碳原子的低级烷基。 结构式（IV）的化合物是制备具有结构式（I）的化合物的有用的中间体化合物。
-
Patent Agency Ranking
公开(公告)号：KR1020120080119A
公开(公告)日：2012-07-16
申请号：KR1020110105049
申请日：2011-10-14
IPC: C07C309/35 , C07D401/12 , A61K31/4545 , A61P37/08
Abstract: PURPOSE: A bepotastine heminapadisilate salt is provided to have high optical purity, and extremely low moisture-absorption, and to have little hardness change, and to have excellent stability in pharmaceutical condition. CONSTITUTION: A (S)-4-[4-[(4-chlorophenyl)-(2-pyridyl) methoxy]piperidine-1-yl] butanoic acid(I) heminapadisilate salt is in chemical formula 1. A manufacturing method of a compound in chemical formula 1 comprises: a step of reacting (S)-4-[4-[(4-chlorophenyl)-(2-pyridyl) methoxy]piperidine-1-yl] butanoic in chemical formula 2 with naphthalene-1,5-disulfonic acid in chemical formula 3. A pharmaceutical composition contains the (S)-4-[4-[(4-chlorophenyl)-(2-pyridyl) methoxy]piperidine-1-yl] butanoic acid(I) heminapadisilate salt.
Abstract translation: 目的：提供贝他斯坦血红蛋白衍生盐，具有高光学纯度，极低的吸湿性，硬度变化小，在制药条件下具有优异的稳定性。 组成：A（S）-4- [4 - [（4-氯苯基） - （2-吡啶基）甲氧基]哌啶-1-基]丁酸（I）heminapadisisate盐是化学式1的制备方法 化学式1中的化合物包括：使化学式2中的（S）-4- [4 - [（4-氯苯基） - （2-吡啶基）甲氧基]哌啶-1-基]丁酸与萘-1反应， 一种药物组合物含有（S）-4- [4 - [（4-氯苯基） - （2-吡啶基）甲氧基]哌啶-1-基]丁酸（I）血红蛋白衍生物盐 。
-
公开(公告)号：KR1020110050880A
公开(公告)日：2011-05-17
申请号：KR1020090107453
申请日：2009-11-09
Applicant: 박사룡
Inventor： 박사룡
IPC: C07D403/12 , A61K31/445 , A61P37/08
Abstract: PURPOSE: A method for preparing non-hygroscopic acid addition salt of an optically active piperidine compound is provided to ensure anti-histamine activity and anti-allergic activity. CONSTITUTION: A camphorsulfonate of a novel (S)-4-[4-[(4-chloforphenyl)(2-pyridyl)methoxy]piperidino]butanoic acid is denoted by chemical formula I and is stable without hygroscopicity. A pharmaceutical composition contains the camphorsulfonate of a novel (S)-4-[4-[(4-chloforphenyl)(2-pyridyl)methoxy]piperidino]butanoic acid as an active ingredient. The camphorsulfonate is prepared by reacting (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butanoic acid.
Abstract translation: 目的：提供一种制备光学活性哌啶化合物的非吸湿性酸加成盐的方法，以确保抗组胺活性和抗过敏活性。 构成：化学式I表示新型（S）-4- [4 - [（4-氯苯基）（2-吡啶基）甲氧基]哌啶子基]丁酸的樟脑磺酸盐，并且在没有吸湿性的情况下是稳定的。 药物组合物含有新型（S）-4- [4 - [（4-氯苯基）（2-吡啶基）甲氧基]哌啶子基]丁酸作为活性成分的樟脑磺酸盐。 樟脑磺酸盐通过（S）-4- [4 - [（4-氯苯基）（2-吡啶基）甲氧基]哌啶子基]丁酸反应制备。
-
公开(公告)号：KR1020090084441A
公开(公告)日：2009-08-05
申请号：KR1020080010641
申请日：2008-02-01
Abstract: A method for dyeing and preserving of timber is provided to prevent decolorization of the timber semi-permanently and to maintain original texture of the timber for a long time. A method for dyeing and preserving of timber includes the following steps of: producing a reactive dye solution; loading the cut timber in a tank; penetrating the reactive dye solution into a core part by maintaining a pressurization state of the timber after injecting the reactive dye solution; penetrating an adhesive agent into the timber inside and the surface; fixing the dye on the timber; injecting the wood preservative which is dissolved in the water into the tank; penetrating the wood preservative; and curing naturally the timber.
Abstract translation: 提供木材染色和保存方法，以防止木材半永久性脱色，并长期保持木材的原始质感。 一种染色和保存木材的方法包括以下步骤：制备活性染料溶液; 将切割的木材装入罐中; 通过在注入活性染料溶液后保持木材的加压状态，将活性染料溶液渗入芯部; 将粘合剂穿入木材内部和表面; 将染料固定在木材上; 将溶解在水中的木材防腐剂注入罐中; 穿透木材防腐剂; 并自然养护木材。
-
-
公开(公告)号：KR1020020074128A
公开(公告)日：2002-09-28
申请号：KR1020020052701
申请日：2002-09-03
IPC: A61F9/02
Abstract: PURPOSE: A goggle for golf putting is provided to help a user to perform an accurate putting action by aligning a hole, a golf ball, and a putter in plural lines formed on the goggle. CONSTITUTION: The goggle comprises a golf putting lens formed with one or several parallel lines or transparent bands having a certain width. In the case of formation of at least two lines or at least one band, a width between the lines or width between bands is about 2-5 millimeters. Alternately, the golf putting lens is foldably mounted under or the tip end of a sun visor of a cap directly.
Abstract translation: 目的：提供用于高尔夫球的护目镜，以帮助用户通过在形成于护目镜上的多条线中对准孔，高尔夫球和推杆来执行准确的放置动作。 构成：护目镜包括由一个或多个平行线或具有一定宽度的透明带形成的高尔夫球拍镜头。 在形成至少两条线或至少一条带的情况下，线之间的宽度或带之间的宽度为约2-5毫米。 或者，高尔夫球把镜片可折叠地直接安装在帽子遮阳板的顶端或顶端。
-
-
-
-
-
-
-
-
-
Search Results
73
records
(took 0.025 seconds)
