公开(公告)号：KR1020110055771A

公开(公告)日：2011-05-26

申请号：KR1020090112323

申请日：2009-11-20

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정현아

IPC: A61K31/37 ,  A23L1/30 ,  A61P3/10 ,  A61K31/7048

Abstract: PURPOSE: A composition containing Cirsium japonicum extract or compound isolated from the extract is provided to suppress aldose reductase and to prevent and treat diabetes or diabetes complication. CONSTITUTION: A composition for preventing or treating diabetes or diabetes compliation contains luteolin compound of chemical formula 1 or leuteolin 5-O-beta-D-glucopyranoside compound of chemical formula 2 as an active ingredient. The compounds are derived from Cirsium japonicum. The composition contains Cirsium japonicum crude extract or non-polar solvent soluble extract as an active ingredient. The crude extract of Cirsium japonicum is isolated using methanol, ethanol, propanol, isopropanol, n-butanol, or mixture solvent thereof.

Abstract translation: 目的：提供含有蓟马提取物或从提取物中分离的化合物的组合物以抑制醛糖还原酶并预防和治疗糖尿病或糖尿病并发症。 构成：用于预防或治疗糖尿病或糖尿病并发症的组合物含有化学式1的木犀草素化合物或化学式2的木犀草素5-O-β-D-吡喃葡萄糖苷化合物作为活性成分。 化合物衍生自日本蓟马。 该组合物含有日本蓟马提取物或非极性溶剂可溶性提取物作为活性成分。 使用甲醇，乙醇，丙醇，异丙醇，正丁醇或其混合溶剂分离日本蓟马的粗提物。

公开(公告)号：KR1020090084439A

公开(公告)日：2009-08-05

申请号：KR1020080010638

申请日：2008-02-01

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  윤나영 ,  정현아

IPC: A61K31/35 ,  A61K31/352 ,  A61K36/489 ,  A61P3/10

Abstract: A composition for preventing and treating diabetic complication is provided to drastically suppress generation activity of rat lens aldose reductase, recombinant human aldose reductase and advanced glycation endproducts (AGEs). A composition for preventing and treating diabetic complication comprises a Sophora flavescens extract or prenylated flavonoid compound isolated from the extract as an active ingredient. The prenylated flavonoid compound is denoted by the structural formula (1) to (14). The diabetic complication is artery scleroma, hypertension, intracerbroventricular infarction, stroke, myocardial infarction, angina, nephropathy, neuropathy, diabetic retinopathy, cataract or the glaucoma. The Sophora flavescens extract or prenylated flavonoid compound isolated from the extract is contained in 0.1-50 %weight based on total weight.

Abstract translation: 提供了用于预防和治疗糖尿病并发症的组合物，以显着抑制大鼠晶状体醛糖还原酶，重组人醛糖还原酶和晚期糖基化终末产物（AGEs）的产生活性。 用于预防和治疗糖尿病并发症的组合物包括从提取物中分离的苦参提取物或异戊烯醛化的类黄酮化合物作为活性成分。 异戊烯酮化合物由结构式（1）〜（14）表示。 糖尿病并发症是动脉硬化，高血压，脑室内梗死，中风，心肌梗死，心绞痛，肾病，神经病，糖尿病性视网膜病，白内障或青光眼。 从提取物中分离的苦参提取物或异戊烯酮化黄酮化合物的含量占总重量的0.1-50％。