公开(公告)号：KR101520615B1

公开(公告)日：2015-05-18

申请号：KR1020130029626

申请日：2013-03-20

Applicant: 서울대학교산학협력단

Inventor： 김영수 ,  윤정환 ,  김현수 ,  진종화

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/48

CPC classification number: G01N33/57438 ,  G01N33/5079 ,  G01N2333/9015 ,  G01N2333/90206 ,  G01N2333/96413

Abstract: 본원은 ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB 및 PABPC1로구성되는군으로부터선택되는하나이상의간암진단또는예후측정용간암바이오마커, 이를포함하는간암진단또는예후측정키트, 조성물및 방법에관한것이다. 본원에따른바이오마커는높은정확도와민감도로간세포암의조기진단, 모니터링및 질병정도를유의적으로예측또는파악할수 있다. 또한혈액또는뇨 등을이용한비침습성검사로간단하고유효성있는간암진단또는모니터링이가능하여, 예를들면 POCT (point of care testing) 개발을통한가정및 일반의원에서의간암조기발견에매우유용할것이다.

公开(公告)号：KR1020140115490A

公开(公告)日：2014-10-01

申请号：KR1020130029626

申请日：2013-03-20

Applicant: 서울대학교산학협력단

Inventor： 김영수 ,  윤정환 ,  김현수 ,  진종화

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/48

CPC classification number: G01N33/57438 ,  G01N33/5079 ,  G01N2333/9015 ,  G01N2333/90206 ,  G01N2333/96413 ,  C12Q1/6886

Abstract: The present invention relates to at least one biomarker for diagnosing liver cancer or measuring liver cancer prognosis, selected from a cluster composed of ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB and PABPC1, and to a kit, a composition and a method for measuring liver cancer prognosis or diagnosing liver cancer comprising the same. The biomarker according to the present invention can predict and identify an early diagnosis of hepatoma, monitoring and degree of the disease with high accuracy and sensitivity. Also simple and significant diagnosis of liver cancer or monitoring can be done with a noninvasive test using blood or urine, and the biomarker is useful in early diagnosis of liver cancer at home or an ordinary clinic through, for example, point of care testing (POCT) development.

Abstract translation: 本发明涉及选自由ACADVL，ANLN，BASP1，MTHFD1，CAPN1，C4A，FLNB和PABPC1组成的簇中的至少一种用于诊断肝癌或测定肝癌预后的生物标志物，以及试剂盒，组合物和 用于测量肝癌预后或诊断包括其的肝癌的方法。 根据本发明的生物标志物可以以高精度和灵敏度预测和鉴定肝癌的早期诊断，监测和疾病程度。 还可以通过使用血液或尿液的无创检测来进行肝癌或监测的简单和重要的诊断，并且生物标志物可用于通过例如护理点测试（POCT）在家或普通诊所的早期诊断肝癌 ）发展。