Abstract:
PURPOSE: A composition for diagnosing small cell cancer is provided to early diagnose small cell lung cancer and to ensure high sensitivity and specificity. CONSTITUTION: A composition for diagnosing small cell cancer contains an antibody which specifically binds to one or more proteins selected from the group consisting of serum paraoxonase 1, isoform 1 of lipopolysaccharide-responsive and beige-like anchor protein, apolipoprotein D, serotransferrin, kallistatin, plasma kallikrein, lumican, histidine-rich glycoprotein, alpha-2-HSglycoprotein, alpha-1B-glycoprotein, and apolipoprotein A-IV. The composition also contains an antibody which specifically binds to one or more proteins selected from the group consisting of haptoglobin, hemopexin, C4b-binding protein alpha chain, complement component C9, CD5-like antigen, inter-alpha-trypsin inhibitor heavy chain H2, serum amyloid P component, isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4, isoform 1 of haptoglobin-related protein, alpha-1-antichymotrypsin, and isoform 1 of alpha-1-antitrypsin.
Abstract:
본 발명은 퀴에신-설프히드릴 옥시다제 1(Quescin-sulfhydryl oxidase 1 : QSOX 1)에 대한 항체, 이를 생산하는 하이브리도마 세포 및 이를 포함하는 폐암 진단용 조성물에 대한 것으로, 특히 퀴에신-설프히드릴 옥시다제 1(QSOX 1) 단백질에 특이적으로 결합하는 항체가 서열번호 2, 서열번호 6 또는 서열번호 9의 단백질 서열(항원결합부위(epitope))에 상응하는 결합부위를 가짐으로서 상기 퀴에신-설프히드릴 옥시다제 1(QSOX 1) 단백질과 높은 반응성을 가지기 때문에, 더욱 명확하게 폐암을 진단할 수 있는 효과가 있다.