中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

123 records (took 0.027 seconds)

    물푸레나무로부터 분리된 프락시딘을 유효성분으로함유하는 톡소플라즈마증의 예방 및 치료용 조성물
    22.
    发明授权
    물푸레나무로부터 분리된 프락시딘을 유효성분으로함유하는 톡소플라즈마증의 예방 및 치료용 조성물 失效
    包含FRAXINUS RHYNCHOPHYLLA分离的FRAXIDIN的组合物，用于预防和治疗类风湿性疾病

    公开(公告)号：KR100830202B1

    公开(公告)日：2008-05-19

    申请号：KR1020070136180

    申请日：2007-12-24

    Applicant: 원광대학교산학협력단

    Inventor： 김윤철 ,  박현 ,  강경화

    IPC: A61K31/351 ,  A61K36/63 ,  A61P33/00

    Abstract: A composition comprising fraxidin isolated from Fraxinus rhynchophylla is provided to show inhibitory effect on toxoplasma, thereby being usefully used as a pharmaceutical composition for preventing and treating toxoplasmosis. A pharmaceutical composition for preventing and treating toxoplasmosis comprises 0.1-50 wt.% of fraxidin isolated from Fraxini Cortex of Fraxinus rhynchophylla and represented by a formula(1). An antiprotozoan supplement agent for preventing and treating toxoplasma comprises the fraxidin.

    Abstract translation: 提供了包含从弗氏毒素（Rhinchophylla）分离的弗氏鼠杆菌的组合物，以显示对弓形体的抑制作用，从而有效地用作预防和治疗弓形虫病的药物组合物。 用于预防和治疗弓形体病的药物组合物包含0.1-50％（重量）的由弗氏rh from（Fraxinus rhynchophylla）的Fraxini Cortex分离并由式（1）表示的菌丝孢菌素。 用于预防和治疗弓形体的抗原生动物补充剂包括弗地克星。

    말라리아 원충에 대한 단일클론 항체 및 이를 이용한말라리아의 진단방법
    23.
    发明公开
    말라리아 원충에 대한 단일클론 항체 및 이를 이용한말라리아의 진단방법 有权
    疟原虫的单克隆抗体和诊断方法

    公开(公告)号：KR1020070097648A

    公开(公告)日：2007-10-05

    申请号：KR1020060027803

    申请日：2006-03-28

    Applicant: 원광대학교산학협력단

    Inventor： 박현 ,  신호준

    IPC: C07K16/18

    CPC classification number: C07K16/205 ,  C07K1/22 ,  C07K2317/14

    Abstract: A monoclonal antibody and a diagnostic method of malaria parasites are provided to improve sensitivity, rapidness and detection amount of diagnosis by using the monoclonal antibody recognizing lactate dehydrogenase(LDH) of malaria parasites. A method for preparing the monoclonal antibody against malaria parasites comprises the steps of: (1) preparing a peptide for the specific site of LDH gene, labeling the MAPs(multiple antigen peptides) as a carrier to the peptide and immunizing a mouse with the peptide antigen; (2) separating serum from the immunized mouse and fusing it with myeloma; (3) selecting hybridoma cells from the fusion cell by using HAT(hypoxanthine, aminopterin and thymidine) medium, and isolating and culturing the selected hybridoma cells to confirm the antibody secretion; (4) selecting a monoclonal cell line producing the monoclonal antibody from the hybridoma cells by using limit dilution method; and (5) mass producing the monoclonal cell line and separating the monoclonal antibody from the cultured cell line by using protein A affinity chromatography, wherein the recombinant antigen has the amino acid sequence of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3; the monoclonal antibody is B4D, C2B, D2H or D7E against the antigen of SEQ ID NO:2 or A4F, A7E, B9G or D5G against the antigen of SEQ ID NO:3; and the malaria parasite is Plasmodium falciparum or Plasmodium vivax.

    Abstract translation: 提供单克隆抗体和疟疾寄生虫的诊断方法，以通过使用识别疟疾寄生虫的乳酸脱氢酶（LDH）的单克隆抗体来提高诊断的敏感性，快速性和检测量。 制备针对疟疾寄生虫的单克隆抗体的方法包括以下步骤：（1）制备LDH基因特异性位点的肽，将MAP（多抗原肽）作为载体标记到肽上并用肽免疫小鼠 抗原; （2）从免疫的小鼠中分离血清并将其与骨髓瘤融合; （3）通过使用HAT（次黄嘌呤，氨基蝶呤和胸苷）培养基从融合细胞中选择杂交瘤细胞，分离培养所选择的杂交瘤细胞以证实抗体分泌; （4）通过使用极限稀释法从杂交瘤细胞中选择产生单克隆抗体的单克隆细胞系; （5）大规模生产单克隆细胞系，并使用蛋白A亲和层析从培养细胞系中分离单克隆抗体，其中重组抗原具有SEQ ID NO：1，SEQ ID NO：2和SEQ ID NO：2的氨基酸序列 ID NO：3; 针对SEQ ID NO：2的抗原或针对SEQ ID NO：3的抗原的A4F，A7E，B9G或D5G的单克隆抗体是B4D，C2B，D2H或D7E; 疟原虫是恶性疟原虫或间日疟原虫。

    조류 인플루엔자 바이러스 감염진단용 형광면역진단키트
    30.
    发明授权
    조류 인플루엔자 바이러스 감염진단용 형광면역진단키트 有权

    公开(公告)号：KR101799142B1

    公开(公告)日：2017-11-20

    申请号：KR1020140111745

    申请日：2014-08-26

    Applicant: 원광대학교산학협력단

    Inventor： 박현 ,  여선주 ,  정점규

    IPC: G01N33/533 ,  C07K16/10 ,  G01N33/58

    Abstract: 본발명은라텍스를매개체로하여조류인플루엔자바이러스의항원인핵단백질에대한항체와형광물질이결합된결합체를포함하는조류인플루엔자바이러스감염진단용형광면역진단키트및 상기키트를이용하여조류인플루엔자바이러스의진단을위한정보를제공하는방법에관한것이다. 본발명의조류인플루엔자바이러스검출용형광면역진단키트를이용하면, 미량의시료를사용하더라도상기시료에포함된조류인플루엔자바이러스와같은다양한유전형의인플루엔자 A 바이러스의핵단백질을종래의키트에비하여약 2.5배향상된검출감도로검출또는정량분석할수 있을뿐만아니라, 인플루엔자 A 바이러스이외의다른호흡기감염성바이러스는검출하지않는특이성을나타내므로, 조류인플루엔자바이러스의감염진단과이를이용한인플루엔자모니터링에활용될수 있을것이다.

Patent Agency Ranking