公开(公告)号：KR1020120113581A

公开(公告)日：2012-10-15

申请号：KR1020110031357

申请日：2011-04-05

Applicant: 전북대학교산학협력단

Inventor： 정경민 ,  이준행 ,  우혜련 ,  김영란 ,  이태희

IPC: C07K16/12 ,  C12N5/20 ,  G01N33/577 ,  A61P31/04

Abstract: PURPOSE: A monoclonal antibody produced from a hydridoma clone is provided to quickly and accurately diagnose, prevent and treat vibrio vulnificus sepsis. CONSTITUTION: A monoclonal antibody binds to vibrio vulnificus RtxA1 antigen prepared by hybridoma cells(deposit number KCLRF-BP-00261) and thermal-treated vibrio vulnificus RtxA1 antigen. The monoclonal antibody binds to 3981-4380th amino acid sites of vibrio vulnificus RtxA1. A composition for detecting vibrio vulnificus contains the monoclonal antibody. A diagnosing kit for detecting vibrio vulnificus contains the monoclonal antibody. A therapeutic agent for treating vibrio vulnificus contains the antibody.

Abstract translation: 目的：提供从Hydridoma克隆产生的单克隆抗体，以快速准确地诊断，预防和治疗创伤弧菌败血症。 构成：单克隆抗体结合由杂交瘤细胞（保藏号KCLRF-BP-00261）和热处理的创伤弧菌RtxA1抗原制备的创伤弧菌RtxA1抗原。 单克隆抗体结合创伤弧菌RtxA1的3981-4380个氨基酸位点。 用于检测创伤弧菌的组合物含有单克隆抗体。 用于检测创伤弧菌的诊断试剂盒含有单克隆抗体。 用于治疗创伤弧菌的治疗剂含有抗体。