公开(公告)号：KR1020100082255A

公开(公告)日：2010-07-16

申请号：KR1020090001660

申请日：2009-01-08

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  안홍열 ,  양현옥 ,  조영애 ,  김동수

IPC: C07F5/02 ,  C07F1/06

CPC classification number: C07F5/027

Abstract: PURPOSE: A novel potassium haloaryltrifluoroborate derivative compound and a method for preparing the same are provided to use in manufacturing medicine and various organic synthesis reactions. CONSTITUTION: A potassium haloaryltrifluoroborate derivative compound is denoted by chemical formula 1. A method for preparing the potassium haloaryltrifluoroborate derivative compound comprises: a step of mixing dihaloaryl compound of chemical formula 2 and borate compound of B(-OR_2)_3 in a solvent; and a step of adding lithium compound of R_2Li and potassium hydrogen fluoride. The solvent is diethyl ether(Et_2O), tetrahydrofuran, 1,4-dioxane, pentane, hexane, or heptanes. The borate compound is timethylborate(B(-OCH_3)_3), triethylborate(B(-OCH_2CH_3)_3), tripropylborate(B(-OCH_2CH_2CH_3)_3), or triphenylborate(B(-OPh)_3).

Abstract translation: 目的：提供新的卤代卤代三氟硼酸钾衍生物化合物及其制备方法，用于制备药物和各种有机合成反应。 构成：卤代芳基三氟硼酸钾衍生物化合物由化学式1表示。卤代芳基三氟硼酸钾衍生物化合物的制备方法包括：将化学式2的二卤代芳基化合物与B（-OR_2）3的硼酸酯化合物在溶剂中混合的步骤; 以及添加R_2Li和氟化氢钾的锂化合物的步骤。 溶剂是二乙醚（Et 2 O），四氢呋喃，1,4-二恶烷，戊烷，己烷或庚烷。 硼酸盐化合物是硼酸三乙酯（B（-OCH 3）3），硼酸三乙酯（B（-OCH 2 CH 3）3）），三异丙基硼酸盐（B（-OCH 2 CH 2 CH 3）3））或三苯基硼酸盐（B（-OPh）3））。

公开(公告)号：KR100894832B1

公开(公告)日：2009-04-24

申请号：KR1020070107775

申请日：2007-10-25

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  안홍열 ,  박영희 ,  김수남 ,  이우정 ,  양현옥 ,  권학철

IPC: C07C39/17 ,  C07C39/18 ,  C07C39/205

Abstract: A stilbene derivatives as PPAR(peroxisome proliferator activation acceptor) alpha/gamma dual agonists is provided for treatment and prevention of obesity, diabetes, skin aging, skin wrinkle and skin hydration. A stilbene derivatives represented by the formula 1 is obtained by reacting a compound represented by the formula 2 and a compound represented by the formula 3. In the formula 1, 2 and 3, R^1 indicates an isoflavonoid group represented by the formula 1-a; R^2 is hydrogen, methyl, ethyl, tert-butyl, benzyl, methoxymethyl, trimethylsilyl, tert-butyldiphenylsilyl, tert-butyldimethylsilyl or triisopropylsilyl; R^3 shows -F, -CF3, -CH3 or -OCH3; A represents cis-, trans- isomers; m is an integer of 0~2; n is an integer of 1~5; p is integer of 0~2; and X shows a halogen atom.

Abstract translation: 提供作为PPAR（过氧化物酶体增殖物激活受体）α/γ双重激动剂的二苯乙烯衍生物用于治疗和预防肥胖症，糖尿病，皮肤老化，皮肤皱纹和皮肤水合。 由式1表示的芪衍生物通过使式2表示的化合物与由式3表示的化合物反应而获得。在式1,2和3中，R 1表示由式1表示的异黄酮基， 一个; R 2是氢，甲基，乙基，叔丁基，苄基，甲氧基甲基，三甲基甲硅烷基，叔丁基二苯基甲硅烷基，叔丁基二甲基甲硅烷基或三异丙基甲硅烷基; R 3表示-F，-CF 3，-CH 3或-OCH 3; A代表顺式，反式异构体; m为0〜2的整数; n为1〜5的整数; p为0〜2的整数; X表示卤素原子。