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公开(公告)号：KR1020140007125A
公开(公告)日：2014-01-17
申请号：KR1020120074251
申请日：2012-07-09
Applicant: 한국전기연구원
IPC: A61B5/00 , A61B5/1455
Abstract: The present invention relates to apparatus for measuring fluorescence for skin autofluorescence so that the autofluorescence may evaluate various diseases by measuring the autofluorescence of skin. For this purpose, in the present invention, the skin fluorescence is measured, and the light from a light source is efficiently accumulated, and it optically integrates the light improvement, whereas the light homogeniety and drawing are irradiated in the skin tissue. The transmission light from the apparatus for measuring skin fluorescence which improves the light efficiency by minimizing the mirroring of the surface of the skin tissue are provided. Moreover, in the present invention, the measurement in error of the skin fluorescence due to the optical scattering generated in the transmission light at the skin surface and skin absorption can simply be amended, and the transmission light of the apparatus for measuring skin fluorescence is provided. Therefore, in the present invention, the optical source section irradiating the excitation light, the optical detecting part, and the light transmission part of the transmission light and fluorescence signal are configured to be delivered so that the optical detecting part and the excitation light irradiated from the optical source section are delivered to the measurement target. The transmission light of the apparatus for measuring skin fluorescence in which each light transmission part comprises a mounting surface, a reflecting surface, and a contact surface. The optical detecting part is arranged in order to detect the transmission light and the fluorescence signal of the excitation light irradiated from the optical source section, and the optical source section or the optical detecting part are mounted so that the reflecting surface reflects the light while being extended to the measurement target from the mounting surface, and the contact surface is connected so that the light can be flowed in to the measurement target.
Abstract translation: 本发明涉及用于测量皮肤自体荧光的荧光的装置，使得自发荧光可以通过测量皮肤的自发荧光来评价各种疾病。 为此，在本发明中，测定皮肤荧光，并且有效地积聚来自光源的光，并且将光的改善光学地整合，而将光均匀性和拉伸照射在皮肤组织中。 提供了用于测量皮肤荧光的装置的透射光，其通过最小化皮肤组织的表面的镜像来提高光效率。 此外，在本发明中，可以简单地修改由于在皮肤表面的透射光中产生的光散射引起的皮肤荧光的误差测量和皮肤吸收，并且提供用于测量皮肤荧光的装置的透射光 。 因此，在本发明中，照射激发光的光源部分，光学检测部分和透射部分的透射光和荧光信号被配置为使得光学检测部分和激发光从 光源部分被传送到测量目标。 用于测量皮肤荧光的装置的透射光，其中每个光透射部分包括安装表面，反射表面和接触表面。 为了检测从光源部照射的激发光的透射光和荧光信号，配置光学检测部，安装光源部或光检测部，使得反射面反射光，同时 从安装表面延伸到测量目标，并且接触表面被连接，使得光可以流入测量对象。
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公开(公告)号：KR1020140007124A
公开(公告)日：2014-01-17
申请号：KR1020120074250
申请日：2012-07-09
Applicant: 한국전기연구원
IPC: A61B5/1455 , G06F19/00
Abstract: The present invention relates to a measurement apparatus for skin autofluorescence for measuring the skin autofluorescence in order to evaluate various diseases by measuring the autofluorescence of skin. For this purpose, the invention provides a skin autofluorescence measuring apparatus detecting reflected light which improves light efficiency by minimizing specular reflection from the surface of a skin tissue and also emitting light having optical density and optical homogeneity improved by uniformly collecting light from a light source to the skin tissue. Moreover, in the present invention, since the diagnosis factor about various diseases is accurately evaluated by simply correcting the measurement error of the skin autofluorescence caused by the reflected light of the incident light in the surface of skin and the scattering and absorption of the light in the skin, the apparatus can improve the diagnostic possibility of various diseases. Therefore, the present invention enables the light irradiation and detection to a standard sample or a measurement target and comprises: a first light source which emits excite light; a second light source which emits light having a wavelength different from the first light source; first and second light detectors installed to detect two different wavelengths of a fluorescence signal and a reflected light signal; a light source switching control unit which controls on/off of the first and second light sources; and a computing unit for computing a skin autofluorescence signal corrected from the fluorescence signal and the reflected light signal detected from the first and second light detectors, wherein the second light source emits light having a wavelength range of skin autofluorescence excited and emitted by the excite light from the first light source.
Abstract translation: 本发明涉及一种用于皮肤自发荧光的测量装置，用于测量皮肤自发荧光，以通过测量皮肤的自发荧光来评价各种疾病。 为此目的，本发明提供了一种皮肤自发荧光测量装置，其检测反射光，其通过使从皮肤组织的表面的镜面反射最小化来提高光效率，并且还发射通过均匀地收集来自光源的光而具有光密度和光学均匀性的光， 皮肤组织。 此外，在本发明中，由于通过简单地校正由皮肤表面的入射光的反射光引起的皮肤自发荧光的测量误差和光的散射和吸收，因此能够准确地评价关于各种疾病的诊断因素 皮肤，该装置可以改善各种疾病的诊断可能性。 因此，本发明能够对标准样品或测量对象进行光照射和检测，并且包括：发射激发光的第一光源; 发射波长不同于第一光源的光的第二光源; 安装第一和第二光检测器以检测两种不同波长的荧光信号和反射光信号; 控制第一和第二光源的开/关的光源切换控制单元; 以及计算单元，用于计算从荧光信号校正的皮肤自发荧光信号和从第一和第二光检测器检测的反射光信号，其中第二光源发射具有由激发光激发和发射的皮肤自发荧光的波长范围的光 从第一个光源。
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公开(公告)号：KR101323646B1
公开(公告)日：2013-11-05
申请号：KR1020120089906
申请日：2012-08-17
Applicant: 한국전기연구원
CPC classification number: A61B1/00186 , A61B1/043 , H04N5/2251 , H04N5/2254 , H04N2005/2255
Abstract: The present invention relates to a filter exchanging device for a television camera for fluorescent endoscope, more specifically the present invention relates to the filter exchanging device for the television camera for the fluorescent endoscope composed to selectively deliver light to the detector sensor of the television camera according to a white light condition or a fluorescent condition in diagnosing a patient using the fluorescent endoscope. The present invention provides the filter exchanging device for the television camera for the fluorescent endoscope composed to easily exchange a filter according to the rotational motion of a camera head by controlling a frame, in which two kinds of filters installed at the inside of the camera head are mounted, to move vertically for enabling a magnetic substance mounted at inside to generate the variation of magnetic force according to the rotation of the camera head with the inside of the camera head, which is connecting the fluorescent endoscope to the detector sensor of the television camera, kept sealed.
Abstract translation: 本发明涉及一种荧光内窥镜用电视摄像机的过滤器更换装置，更具体地说，本发明涉及用于荧光内窥镜的电视摄像机的过滤器更换装置，其特征在于，将所述过滤器更换装置选择性地将光传送到所述电视摄像机的检测传感器 在使用荧光内窥镜诊断患者时达到白光条件或荧光条件。 本发明提供了一种用于荧光内窥镜的电视摄像机的滤光器更换装置，其特征在于，通过控制框架，根据相机头的旋转运动容易地更换滤光器，其中安装在相机头内部的两种滤色器 被安装成垂直移动，以使安装在内部的磁性物质能够根据相机头的旋转产生磁力的变化，相机头的内部将荧光内窥镜连接到电视的检测器传感器 相机，保持密封。
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公开(公告)号：KR1020130106985A
公开(公告)日：2013-10-01
申请号：KR1020120028724
申请日：2012-03-21
Applicant: 한국전기연구원
IPC: A61B5/00 , A61B5/1455
Abstract: PURPOSE: A skin fluorescence measurement apparatus of a transmitted light detection type is provided to simply amend errors due to the scattering and absorbing of light, thereby correctly diagnosing diseases. CONSTITUTION: A first light source (111) irradiates excitation light. A second light source (112) irradiates light having a wavelength which is different from that of the first light source. First and second optical detectors (121,122) detect two different wavelengths from a fluorescence signal and a transmitted light signal. A light source switching controller (134) controls the first and second light sources so that the first and second light sources can be turned on or off. An operation unit (210) produces a skin fluorescence signal corrected from the fluorescence signal and the transmitted light signal.
Abstract translation: 目的：提供透射光检测型的皮肤荧光测量装置，以简单地修正由于光的散射和吸收引起的误差，从而正确地诊断疾病。 构成：第一光源（111）照射激发光。 第二光源（112）照射具有与第一光源的波长不同的波长的光。 第一和第二光学检测器（121,122）从荧光信号和透射光信号中检测两种不同的波长。 光源切换控制器（134）控制第一和第二光源，使得可以打开或关闭第一和第二光源。 操作单元（210）产生从荧光信号和透射光信号校正的皮肤荧光信号。
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公开(公告)号：KR1020090036304A
公开(公告)日：2009-04-14
申请号：KR1020070101398
申请日：2007-10-09
Applicant: 한국전기연구원
IPC: A61N5/06
CPC classification number: A61N5/0616 , A61B2018/207 , A61N2005/063 , A61N2005/0659 , A61N2005/0661
Abstract: A light source system for phototherapy of skin disease is provided, which has the effect of the optical spectrum expansion, the increment of the quantity of light, and the uniformity increment of the illumination spectrum. A light source system for phototherapy of skin disease comprises: a shortwave light source having the main part emission light of the short wavelength spectrum region; a long wavelength light source having the main part emission light of the long wavelength spectrum region; a light guide delivering the light which is inputted in order to be provided to the treatment position; and a mirror which is located at the front of the entrance face of the light guide to make only the light of the selected wavelength range of the light come in.
Abstract translation: 提供了一种用于皮肤疾病光疗的光源系统，其具有光谱扩展，光量增加和照明光谱的均匀性增量的效果。 一种用于皮肤疾病光疗的光源系统，包括：具有短波长光谱区域的主要部分发光的短波光源; 具有长波长光谱区域的主要部分发光的长波长光源; 传送光，以便输入以便提供给治疗位置的光; 以及位于光导入射面的前方的仅使光的所选波长范围的光进入的反射镜。
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Patent Agency Ranking
公开(公告)号：KR1020070076153A
公开(公告)日：2007-07-24
申请号：KR1020060005203
申请日：2006-01-18
Applicant: 한국전기연구원
IPC: A61B5/00
Abstract: A fluorescence video system for diagnosing a skin is provided to improve accuracy of the diagnosis by installing a complex light source irradiating white light and excited light in a barrel. A fluorescence video system for diagnosing a skin includes an image detector(11), an image processor(12), and an image monitor(13). The image detector(11) includes a barrel with an opening at a front end thereof to be shielded from the light by contacting with the skin. The image processor(12) receives an image signal inputted from the image detector(11), and processes the image signal to an image or a video image. The image monitor(13) displays the image or the video image processed by the image processor(12).
Abstract translation: 提供用于诊断皮肤的荧光视频系统，以通过在筒中安装将白光和激发光照射的复合光源来提高诊断的准确度。 用于诊断皮肤的荧光视频系统包括图像检测器（11），图像处理器（12）和图像监视器（13）。 图像检测器（11）包括在其前端具有开口的筒体，以通过与皮肤接触而与光屏蔽。 图像处理器（12）接收从图像检测器（11）输入的图像信号，并将图像信号处理成图像或视频图像。 图像监视器（13）显示由图像处理器（12）处理的图像或视频图像。
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公开(公告)号：KR100500610B1
公开(公告)日：2005-07-11
申请号：KR1020030075916
申请日：2003-10-29
Applicant: 한국전기연구원
IPC: G02B21/06
CPC classification number: G02B21/16
Abstract: 본 발명은 형광 현미경 장치 및 이를 사용한 관측 방법에 관한 것으로, 광학적 잡음을 감소시키고, 보다 감도 높은 이미지를 얻을 수 있어 형광 물질의 농도, 양 및 위치 등에 관한 정확한 정보를 얻는 것이 가능하며, 여기 및 형광 파장의 범위가 다른 다수의 형광 물질이 분포된 경우에도 구별된 이미지의 동시 처리가 가능하여 그 각각에 대한 정보를 용이하게 얻을 수 있도록 한다. 본 발명의 형광 현미경은: 대물 렌즈; 형광 물질을 포함하는 하나 이상의 미세 객체를 수용하며, 형광 물질을 여기 시키기 위한 여기 광의 경로를 제공하며, n
1 의 굴절율을 갖는 제1 매질부; 및 제1 매질부와 대물 렌즈 사이의 위치에 설치되며, 제1 매질부와 접한 경계면에서 제1 매질부를 통해 입사된 여기 광을 전반사하며, n
3 의 굴절율을 갖는 제3 매질부를 포함하며, 여기서 제3 매질부와 제1 매질부의 굴절율은, n
1 > n
3 의 관계를 만족하며, 여기 광의 경계면에 대한 입사각은 임계각 이상이며, 제1 매질부 내의 여기 광의 통과 경로 내에 존재하는 미세 객체에 포함된 형광 물질이 여기 되어 방출하는 형광을 대물렌즈에 의하여 포착함으로써 미세 객체를 관측한다.-
公开(公告)号：KR1020140020532A
公开(公告)日：2014-02-19
申请号：KR1020120087175
申请日：2012-08-09
Applicant: 한국전기연구원
CPC classification number: F21V9/08 , A61B5/0059 , A61N5/06 , A61N5/0616 , A61N5/062 , A61N2005/065 , A61N2005/0665 , A61N2005/0667
Abstract: The present invention relates to a complex light source device and more specifically, to a complex light source device for optical diagnosis and optical treatment which supplies radiation light through an optical wave guide efficiently to improve the accuracy in optical diagnosis of diseases inside or outside the human body, or specifically tumors such as cervical cancer, and enhance the efficiency of optical treatment. In particular, the present invention is to provide a complex light source device for optical diagnosis and optical treatment capable of increasing the expansion of an optical spectrum and the uniformness of the lighting spectrum, suppressing harmful spectrum elements, and supplying the optimum white light continuously even as time passes. To do so, the present invention provides a complex light source device for optical diagnosis and optical treatment which includes: a non-coherent first light source; a coherent second light source; an optical wave guide for delivering light emitted from the first and the second light source; and an interference filter placed on the light path of the first light source. The light emitted from the second light source is reflected by the interference filter and reaches the optical wave guide. Between the first light source and the optical wave guide, a compensation filter which compensates the output spectrum of the first light source and converts the result to a preset reference output spectrum; and an adjustable aperture which corrects the color temperature change as time passes; are further included.
Abstract translation: 复合光源装置技术领域本发明涉及复合光源装置，更具体地说，涉及一种用于光学诊断和光学处理的复合光源装置，其通过光波导有效地提供辐射光，以提高人体内外的疾病的光学诊断的准确性 身体或具体肿瘤如宫颈癌，并提高光学治疗的效率。 特别地，本发明提供一种用于光学诊断和光学处理的复合光源装置，其能够增加光谱的扩展和照明光谱的均匀性，抑制有害光谱元素，并连续地提供最佳白光 随着时间流逝。 为此，本发明提供一种用于光学诊断和光学处理的复合光源装置，其包括：非相干第一光源; 一致的第二光源; 用于传送从第一和第二光源发射的光的光波导; 以及设置在第一光源的光路上的干涉滤光器。 从第二光源发射的光被干涉滤光器反射并到达光波导。 在第一光源和光波导之间，补偿滤波器，补偿第一光源的输出光谱，并将结果转换为预设的参考输出光谱; 以及随着时间的推移校正色温变化的可调孔径; 进一步包括在内。
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公开(公告)号：KR101172745B1
公开(公告)日：2012-08-14
申请号：KR1020100008286
申请日：2010-01-29
Applicant: 한국전기연구원
IPC: A61B5/0275 , A61B5/1455
CPC classification number: A61B5/0071 , A61N5/062 , A61N2005/0628
Abstract: 본 발명은 형광 검출 및 광역학 치료 장치에 관한 것으로서, 더욱 상세하게는 복합 광원을 대상 동물에 조사(illumination)하여, 대상 동물 조직의 생체 내(in-vivo) 또는 생체 밖(ex-vivo)의 실험에서 발생하는 형광과 반사광 또는 수 개의 형광을 실시간으로 동시에 영상 관찰 및 기록할 수 있도록 한 생물 의학 영상(biomedical imaging) 분야에 유용한 동물 실험용 형광 검출 및 광역학 치료 장치에 관한 것이다.
이를 위해, 본 발명은 연속적인 발광을 하면서 관찰 대상에 광을 조사하는 수 개의 간섭성 및 비간섭성의 광원들로 이루어진 복합 광원부와; 관찰 대상의 영상을 형성하고, 영상처리 제어부에 영상을 투사하는 광학 영상부와; 단일칩 다중 분광 센서와 영상처리 제어부를 포함하는 다중 분광 영상부와; 관찰 대상과 단일칩 다중 분광 센서 사이에 설치되어, 관찰 대상으로부터 반사되는 일부 광을 차폐하고, 일부 광과 형광을 투과시키는 차폐 필터와; 다중 분광 영상부로부터 획득된 영상의 처리, 분석, 재생 및 저장을 하며, 디스플레이 장치에 영상을 보내고 관련된 모든 소자들을 제어하는 컴퓨터 시스템; 컴퓨터 시스템의 프로세싱 결과를 디스플레이하는 디스플레이 장치; 를 포함하여 구성된 것을 특징으로 하는 형광 검출 및 광역학 치료 장치를 제공한다.-
公开(公告)号：KR101117195B1
公开(公告)日：2012-03-07
申请号：KR1020090068424
申请日：2009-07-27
Applicant: 한국전기연구원
Abstract: 본발명의피부노화도측정장치에따르면피부노화도를정확하고간단하게측정할수 있을뿐만아니라태양광에의한노화도(photo-aging)를정확하게알 수있어피부미용및 피부노화도방지를위한약제등의개발을효율적으로수행할수 있는효과가있다.
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