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公开(公告)号：KR1020150044206A
公开(公告)日：2015-04-24
申请号：KR1020130123304
申请日：2013-10-16
Applicant: 한국전자통신연구원
CPC classification number: G01J3/4412 , G01J2003/4424 , G01N21/658
Abstract: 나노홀어레이를포함하는표면강화라만분광용기판및 그제조방법이개시된다. 표면강화라만분광용기판은베이스층상에제1홀어레이를가지는제1금속층을형성한후 그표면에제2홀어레이를가지는제2금속층을표면화학반응을통해성장시킨다. 이러한제2금속층에형성된제2홀어레이가최종적으로얻어지는제2홀어레이가되며, 이는제1홀어레이의각 홀보다작은사이즈의홀들로이루어진다. 이와같이표면화학반응을이용할경우, 제2홀어레이의각 홀의크기와제2홀어레이를형성하는금속층의표면거칠기, 표면을형성하는입자들의크기등이화학반응조건에따라서조절될수 있어표면증강라만용기판을형성하기가용이하다. 또한, 저비용으로재현성높은나노홀어레이를가지는표면강화라만분광용기판을제조할수 있다.
Abstract translation: 本发明涉及用于表面增强拉曼光谱嵌入式纳米孔阵列的基板及其制造方法。 在基底层中形成具有第一孔阵列的第一金属层之后的基底的表面增强拉曼光谱生长在其表面上具有第二阵列的孔的表面化学物质和第二金属层上。 第二孔阵列最终获得形成在第二金属层中的第二孔阵列，其包括比第一孔阵列的每个孔的孔小的尺寸。 当以这种方式使用表面化学反应时，可以根据诸如颗粒尺寸的反应条件来调节第二孔，阵列尺寸的每个孔和金属层的表面粗糙度以形成第二孔阵列 形成表面具有表面增强以形成拉曼的基底。 此外，可以制造用于表面增强拉曼光谱的基板具有低成本，可再现的纳米孔阵列。
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公开(公告)号：KR1020130064461A
公开(公告)日：2013-06-18
申请号：KR1020110131088
申请日：2011-12-08
Applicant: 한국전자통신연구원
IPC: G01N35/08 , G01N33/49 , G01N1/28 , G01N33/574
Abstract: PURPOSE: A device for separating tumor cells from blood is provided to minimize damage to collected tumor cells by using a microstructure which controls pressures. CONSTITUTION: A device for separating tumor cells from blood includes inlets(102i), a fluid channel(110), and outlets(102o). Blood is injected through the inlets. The fluid channel is equipped with at least one loop-shaped microstructure(120). The blood is transferred through the fluid channel, and the fluid channel collects tumor cells from the blood. Blood without the tumor cells is discharged through the outlet. The microstructure includes a body(B), an introducing unit, a discharging unit, and a plurality of inlets, and a plurality of outlets. The body is composed of two parallel lines. The introducing unit and the discharging unit are hemi-circular shapes and are adjacent to the inlet and outlet by being in contact with both sides of the body. The inlets are larger than the tumor cells and are formed at 45 degrees of the center of the hemi-circular shape. The outlets are smaller than the tumor cells and larger than blood corpuscle. The outlets are formed over the entire discharging unit.
Abstract translation: 目的：提供用于从血液中分离肿瘤细胞的装置，以通过使用控制压力的微结构来最小化对收集的肿瘤细胞的损伤。 构成：用于从血液中分离肿瘤细胞的装置包括入口（102i），流体通道（110）和出口（102o）。 血液通过入口注射。 流体通道配备有至少一个环形微结构（120）。 血液通过流体通道传输，流体通道从血液中收集肿瘤细胞。 没有肿瘤细胞的血液通过出口排出。 微结构包括主体（B），引入单元，排出单元和多个入口以及多个出口。 身体由两条平行线组成。 引入单元和排出单元是半圆形的并且通过与主体的两侧接触而与入口和出口相邻。 入口大于肿瘤细胞，并形成在半圆形中心的45度处。 出口小于肿瘤细胞，大于血小板。 出口形成在整个排放单元上。
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公开(公告)号：KR1020130014322A
公开(公告)日：2013-02-07
申请号：KR1020120016463
申请日：2012-02-17
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/532 , G01N27/72 , B82Y15/00
Abstract: PURPOSE: A multiple analyzer and a method for analyzing cancer cells in blood are provided to analyze cancer cells in each cancer. CONSTITUTION: A multiple analyzer comprises a magnetophoresis sorting part, a magnetic field measuring unit, and an analyzing and determining unit. The magnetophoresis sorting part comprises: a solution inlet; a saline solution inlet; a channel which is connected to the solution inlet and the saline solution inlet; one or more ferromagnetism patterns which are placed under the bottom of the channel; a first discharging path which is connected to the channel and discharges a first kind of material contained in the solution; and a second discharge path which is connected to the channel and discharges a second kind of material contained in the solution. A method for analyzing cancer cells in blood comprises the following steps: a step of mixing blood to be tested with a magnetic nanoparticle which is conjugated with a cancer cell-specific antibody, and preparing a mixture solution(S10); a step of dividing the mixture solution into normal cells and cancer cells by magnetophoresis(S20); a step of continuously measuring a magnetic field of the cancer cells(S30); and a step of analyzing and determining cancer cells in each cancer using the magnetic field of the cancer cell(S40). [Reference numerals] (AA) Blood; (BB) Magnetic nanoparticles; (CC) Mixture solution; (S20) Magnetophoresis division: dividing cancer cells and normal cells; (S30) Continuously measuring the magnetic field of the cancer cells; (S40) Analyzing/determining the cancer kinds of cancer cells
Abstract translation: 目的：提供多种分析仪和分析血液中癌细胞的方法，以分析各种癌症中的癌细胞。 构成：多分析仪包括磁电泳分选部，磁场测定部以及分析判断部。 磁电泳分选部分包括：溶液入口; 盐水溶液入口; 连接到溶液入口和盐水溶液入口的通道; 放置在通道底部下方的一个或多个铁磁图案; 第一排出路径，其连接到所述通道并排出所述溶液中包含的第一种材料; 以及第二排出路径，其连接到通道并排出溶液中包含的第二种材料。 用于分析血液中的癌细胞的方法包括以下步骤：将待测血液与与癌细胞特异性抗体结合的磁性纳米颗粒混合，制备混合液（S10）; 通过磁电泳将混合溶液分成正常细胞和癌细胞的步骤（S20）; 连续测量癌细胞的磁场的步骤（S30）; 以及使用癌细胞的磁场分析和确定各癌症中的癌细胞的步骤（S40）。 （附图标记）（AA）血液; （BB）磁性纳米粒子; （CC）混合溶液; （S20）磁电泳分割：分割癌细胞和正常细胞; （S30）连续地测量癌细胞的磁场; （S40）分析/确定癌细胞的癌症种类
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公开(公告)号：KR1020130014305A
公开(公告)日：2013-02-07
申请号：KR1020110130311
申请日：2011-12-07
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/553 , G01N27/72
Abstract: PURPOSE: A multiple sorting apparatus and a method for sorting cancer cells in blood using the same are provided to sort the cancer cells by each kind of cancer and to simply diagnose cancer development. CONSTITUTION: A multiple sorting apparatus(100) comprises a first magnetophoresis sorting part(MP1) and a second magnetophoresis sorting part(MP2). The first magnetophoresis sorting part has a first channel(CH1). One side of the first channel is connected with a mixture solution inlet port(IP1) and a first saline solution inlet port(IP2). The other side of the first channel is connected with a first outlet port(OP1) and a preliminary separation path(PSP). The second magnetophoresis sorting part has a second channel. One side of the first channel is connected with a second saline solution inlet port(IP3) and a preliminary separation path. The other side of the second channel is connected with the second outlet port(OP2).
Abstract translation: 目的：提供使用其分选血液中的癌细胞的多重分选装置和方法，以通过各种癌症对癌细胞进行分类并简单地诊断癌症发展。 构成：多重分选装置（100）包括第一磁电泳分选部（MP1）和第二磁电泳分选部（MP2）。 第一磁电泳分选部具有第一通道（CH1）。 第一通道的一侧与混合溶液入口（IP1）和第一盐水溶液入口（IP2）连接。 第一通道的另一侧与第一出口（OP1）和初步分离路径（PSP）连接。 第二磁电泳分选部件具有第二通道。 第一通道的一侧与第二盐水溶液入口（IP3）和初步分离路径连接。 第二通道的另一侧与第二出口（OP2）连接。
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