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21.发明公开신규한 세팔로스포린계 화합물 및 약제학적으로 허용되는염과 그의 제조 방법 失效具有改善抗微生物活性，特别是耐甲氧西林金黄色葡萄球菌（MRSA）菌株及其药学上可接受的盐及其制备方法的CEPHOROSPORIN衍生物
公开(公告)号：KR1020050001245A
公开(公告)日：2005-01-06
申请号：KR1020030042826
申请日：2003-06-27
IPC: C07D501/24
CPC classification number: C07D501/00 , Y02P20/55
Abstract: PURPOSE: Cephalosporin derivatives, its pharmaceutically acceptable salts and a manufacturing process thereof are provided, which cephalosporin derivatives have improved anti-microbial activity, particularly, for methicillin-resistant Staphylococcus aureus(MRSA) strain, so that they can be useful for antibiotics. CONSTITUTION: The cephalosporin derivatives represented by formula (I), or pharmaceutically acceptable salts thereof are provided, wherein X, Y and Z are the same or different, and independently hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 halogenoalkyl, C1-6 alkoxy alkyl or C3-6 cycloalkyl; R1 is an isoxazol compound in which the 3-site is substituted with a compound of formula (A), wherein Q is a substituent useful for cephalosporin-based compound, and is selected from hydrogen, halogen, hydroxyl, mercapto, cyano, carboxy, carboxylic acid, ester, carbamoyloxy, carbamoyl, N,N-dimethylcarbamoyl, C1-4 alkyl, C1-4 alkyloxy, halogen substituted alkyl, aryl or hetero ring substituent; and R2 is hydrogen, an ester-forming group as an ester of carboxy group, salt-forming atom or carboxy-protecting group. The process for preparing the cephalosporin derivatives represented by formula (I), or pharmaceutically acceptable salts thereof comprises reacting an ilide compound of formula (VI) with an aldehyde compound of formula (VII) in the presence of base and organic solvent at -40 to 25 deg. C.
Abstract translation: 目的：提供头孢菌素衍生物及其药学上可接受的盐及其制备方法，其头孢菌素衍生物具有改善的抗微生物活性，特别是耐甲氧西林金黄色葡萄球菌（MRSA）菌株，因此它们可用于抗生素。 构成：提供由式（I）表示的头孢菌素衍生物或其药学上可接受的盐，其中X，Y和Z相同或不同，独立地是氢，卤素，C 1-6烷基，C 1-6烷氧基， 6卤代烷基，C 1-6烷氧基烷基或C 3-6环烷基; R1是其中3-位被式（A）化合物取代的异恶唑化合物，其中Q是可用于头孢菌素类化合物的取代基，并且选自氢，卤素，羟基，巯基，氰基，羧基， 羧酸，酯，氨基甲酰氧基，氨基甲酰基，N，N-二甲基氨基甲酰基，C 1-4烷基，C 1-4烷氧基，卤素取代的烷基，芳基或杂环取代基; 并且R 2是氢，作为羧基的酯形成基团，成盐原子或羧基保护基。 制备由式（I）表示的头孢菌素衍生物或其药学上可接受的盐的方法包括：在碱和有机溶剂的存在下，使式（VI）的铱化合物与式（Ⅶ）的醛化合物在-40至 25度 C。
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公开(公告)号：KR1020040032299A
公开(公告)日：2004-04-17
申请号：KR1020020061374
申请日：2002-10-09
Applicant: 한국과학기술연구원
IPC: C22B3/08
CPC classification number: Y02P10/234
Abstract: PURPOSE: A method for recovering gold from gold concentrate by acid thiourea process is provided to leach gold from an acid thiourea aqueous solution environmentally and efficiently by using sulfuric acid as an acidity adjusting agent, thiourea as a leaching agent and air externally injected along with iron ions as an oxidizer. CONSTITUTION: The method comprises the steps of polishing gold concentrate; adding sulfuric acid as an acidity adjusting agent and thiourea as a leaching agent to an aqueous solution containing the polished gold concentrate; and leaching gold from the gold concentrate contained in an acid thiourea aqueous solution using air injected from the outside along with iron ions dissolved from the gold concentrate, wherein the gold concentrate in the polishing step has a grain size corresponding to a sieve size of 400 meshes or less, wherein an ore solution of the gold concentrate has a concentration of 5 to 15 g/L, wherein the sulfuric acid has a concentration of 1 to 3 wt.%, wherein the thiourea has a concentration of 3 to 6 wt.%, wherein the air along with the iron ions dissolved from the gold concentrate is injected into the solution in a flow rate of 100 to 200 ml/min in the leaching step, wherein the leaching step is performed by agitating the solution to an agitation speed of 300 to 400 revolutions per minute, and wherein the leaching step is performed at a reaction temperature of 20 to 30 deg.C for 3 to 4 hours.
Abstract translation: 目的：提供一种通过酸性硫脲方法从金浓缩物中回收金的方法，通过使用硫酸作为酸度调节剂，硫脲作为浸出剂和外部与铁一起注入的空气，环境和有效地从酸性硫脲水溶液中浸取金 离子作为氧化剂。 构成：该方法包括抛光金精矿的步骤; 将硫酸作为酸度调节剂和硫脲作为浸出剂加入到含有抛光金精矿的水溶液中; 以及使用从外部注入的空气以及从金浓缩物中溶解的铁离子，从酸性硫脲水溶液中的金浓缩物中浸出金，其中在研磨步骤中的金浓缩物具有对应于400目筛 其中所述金浓缩物的矿石溶液的浓度为5至15g / L，其中所述硫酸的浓度为1至3重量％，其中所述硫脲的浓度为3至6重量％ 其中在浸出步骤中将空气与从金浓缩物溶解的铁离子一起以100-200ml / min的流速注入溶液中，其中浸出步骤通过将溶液搅拌至搅拌速度 300〜400转/分钟，其中浸出步骤在20〜30℃的反应温度下进行3〜4小时。
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公开(公告)号：KR100420733B1
公开(公告)日：2004-03-02
申请号：KR1020010019967
申请日：2001-04-13
Applicant: 한국과학기술연구원
IPC: C01G25/00
Abstract: PURPOSE: A separation method of high purity zirconium using a column extractor is provided in which high purity zirconium is continuously separated and extracted economically and environment friendly from a zirconium oxychloride (ZrOCl2·8H2O) aqueous solution containing hafnium using the column extractor. CONSTITUTION: The separation method of high purity zirconium using a column extractor comprises first extracting step of extracting zirconium by containing zirconium in an organic solution(2) containing tributyl phosphate (TBP) as a zirconium extractant from the upper part of a first column extractor(10) using difference of specific gravity after repeating mixing and separation of the aqueous solution and the organic solution(2) by supplying a hafnium contained zirconium oxychloride aqueous solution(1) and an organic solution containing tributyl phosphate (TBP) as an extractant to upper and lower parts of the first column extractor(10) respectively; and second extracting step of reverse extracting zirconium by containing zirconium in water from the lower part of the second column extractor using difference of specific gravity after repeating mixing and separation of the organic solution(2) and water by supplying the organic solution(9) extracted in the first extracting step and water to lower and upper parts of a second column extractor respectively.
Abstract translation: 目的：提供一种使用柱萃取器的高纯度锆的分离方法，其中使用柱萃取器从包含铪的二氯氧化锆（ZrOCl 2＆8H 2 O）水溶液中连续分离和提取经济和环境高纯度的锆。 构成：使用柱萃取器的高纯度锆的分离方法包括：第一萃取步骤，通过在第一萃取塔的上部含有锆的有机溶液（2）中萃取锆，所述有机溶液（2）含有作为锆萃取剂的磷酸三丁酯（TBP） （1）和含有磷酸三丁酯（TBP）作为萃取剂的有机溶液供给上层（2）后，利用比重差异重复水溶液和有机溶液（2） 和第一柱提取器（10）的下部分; 以及通过供给有机溶液（9）而重复混合并分离有机溶液（2）和水之后，通过使用比重差从第二柱萃取器的下部在水中含有锆来逆萃取锆的第二萃取步骤 在第一提取步骤中，水分别通过第二塔提取器的上部和下部。
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公开(公告)号：KR1020030080485A
公开(公告)日：2003-10-17
申请号：KR1020020019137
申请日：2002-04-09
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A surface modification method of activated carbon for wastewater treatment is provided, which improves adsorption capacity of recalcitrant organic contaminants of industrial wastewater by reducing the surface of activated carbon. CONSTITUTION: The surface modification method of activated carbon comprises the process of reducing activated carbon by directly reacting dithionite ions (S2O4¬2-) produced through electrolysis of sulfurous acid gas with activated carbon, wherein the activated carbon surface modification method is performed by carrying out electrolysis as agitating the activated carbon after injecting activated carbon into the cathode chamber of an electrolytic cell comprising cathode chamber, anode chamber and separation membrane positioned between the cathode chamber and anode chamber and using an aqueous sulfuric acid solution into which sulfurous acid gas is dissolved as a cathode solution and an aqueous sulfuric acid solution as an anode solution, wherein anode plate of the electrolytic cell used for electrolysis is lead or graphite, cathode plate is stainless steel or graphite, and current density is 10 to 200 mA/cm¬2, wherein 0.1 to 2.0 M of sulfuric acid solution saturated with sulfurous acid gas is used as the cathode solution, and wherein the sulfurous acid gas is consistently supplied into the cathode chamber from the outside during the process of performing electrolysis after injecting only the sulfuric acid solution as the cathode solution into the cathode chamber.
Abstract translation: 目的：提供用于废水处理的活性炭表面改性方法，通过减少活性炭的表面，提高工业废水的顽固有机污染物的吸附能力。 构成：活性炭的表面改性方法包括通过将亚硫酸气体与活性炭电解直接反应的连二亚硫酸盐离子（S2O4-2-）直接反应来还原活性炭的方法，其中通过进行活性炭表面改性方法 在将活性炭注入到阴极室，阳极室和位于阴极室和阳极室之间的分离膜的电解池的阴极室中，并且使用其中溶解有亚硫酸气体的硫酸水溶液作为搅拌活性炭时进行电解 阴极溶液和硫酸水溶液作为阳极溶液，其中用于电解的电解池的阳极板为铅或石墨，阴极板为不锈钢或石墨，电流密度为10〜200mA / cm 2， 其中用亚硫酸饱和的0.1〜2.0M的硫酸溶液 使用气体作为阴极溶液，并且在仅将硫酸溶液注入阴极溶液作为阴极室之后，在进行电解的过程中，从外部将亚硫酸气体一贯地供给到阴极室。
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公开(公告)号：KR1020020079221A
公开(公告)日：2002-10-19
申请号：KR1020010019967
申请日：2001-04-13
Applicant: 한국과학기술연구원
IPC: C01G25/00
CPC classification number: C01G25/003 , C01P2006/80 , C22B34/14
Abstract: PURPOSE: A separation method of high purity zirconium using a column extractor is provided in which high purity zirconium is continuously separated and extracted economically and environment friendly from a zirconium oxychloride (ZrOCl2·8H2O) aqueous solution containing hafnium using the column extractor. CONSTITUTION: The separation method of high purity zirconium using a column extractor comprises first extracting step of extracting zirconium by containing zirconium in an organic solution(2) containing tributyl phosphate (TBP) as a zirconium extractant from the upper part of a first column extractor(10) using difference of specific gravity after repeating mixing and separation of the aqueous solution and the organic solution(2) by supplying a hafnium contained zirconium oxychloride aqueous solution(1) and an organic solution containing tributyl phosphate (TBP) as an extractant to upper and lower parts of the first column extractor(10) respectively; and second extracting step of reverse extracting zirconium by containing zirconium in water from the lower part of the second column extractor using difference of specific gravity after repeating mixing and separation of the organic solution(2) and water by supplying the organic solution(9) extracted in the first extracting step and water to lower and upper parts of a second column extractor respectively.
Abstract translation: 目的：提供使用柱萃取器的高纯度锆的分离方法，其中使用柱萃取器从含有铪的氯氧化锆（ZrOCl 2·8H 2 O）水溶液经济地和环境友好地连续分离提取高纯度锆。 构成：使用柱提取器的高纯度锆的分离方法包括首先从含有锆的有机溶液（2）中提取锆的第一提取步骤，所述有机溶液（2）含有作为锆萃取剂的磷酸三丁酯（TBP），从第一塔提取器的上部（ 10）通过将含有氯氧化锆水溶液（1）的铪和含磷酸三丁酯（TBP）作为萃取剂的有机溶液供给上层，重复混合分离水溶液和有机溶液（2）后使用比重差 和第一柱提取器（10）的下部分; 以及第二提取步骤，通过在重复混合和分离有机溶液（2）和水之后使用比例重量从第二塔提取器的下部含有锆来回收锆，所述有机溶液（2）和水通过提供所提取的有机溶液（9） 在第一提取步骤中分别向第二塔提取器的下部和上部分提供水。
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Patent Agency Ranking
公开(公告)号：KR1019960003546A
公开(公告)日：1996-02-23
申请号：KR1019940016807
申请日：1994-07-13
Applicant: 한국과학기술연구원
IPC: A01G1/00
Abstract: 본 발명은 기지 토양의 주원료로서 입도 5mm 이하인 분말 형태의 광물질 점토인 규조토 20 내지 90중량%, 제올라이트 10 내지 50중량% 및 벤토나이트 0 내지 30중량%를 혼합하는 단계, 상기 혼합물에 약 0.1 내지 1.5중량%의 명반 또는 황산알루미늄 등의 수용성 알루미늄 혼합물의 용액을 첨가하여 상토의 pH가 약 3 내지 7이고 수분 함량이 약 15 내지 50%가 되도록 혼합하는 단계, 상기 단계에서 얻은 입자들을 입도 10mm 이하로 조립하여 미립의 광물질 점토를 응집시키는 단계를 포함하는 것을 특징으로 하여, 보습율, 보수율 및 투수성 등의 물리화학적 특성이 향상된 육모용 상토의 제조 방법에 관한 것이다.
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公开(公告)号：KR1019960000647B1
公开(公告)日：1996-01-11
申请号：KR1019920022561
申请日：1992-11-27
Applicant: 한국과학기술연구원
IPC: B01D11/04
Abstract: first extracting zirconium solution containing hafnium with Versatic acid 10 of 0.5-2.0M in organic solvent, second extracting the organic component with aqueous solution containing HCl of 0.5-2.0M; obtaining ZrOCl28H2O crystal by vaporizing and concentrating an aqueous solution containing Zr; and hydrolyzing ZrOCl28H2O crystal with amnia, and baking.
Abstract translation: 首先用有机溶剂中的0.5-2.0M的Versatic酸10萃取含有铪的锆溶液，然后用0.5-2.0M的HCl水溶液萃取有机组分; 通过蒸发并浓缩含Zr的水溶液获得ZrOCl28H2O晶体; 并用氨纶水解ZrOCl28H2O晶体，烘烤。
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公开(公告)号：KR102251544B1
公开(公告)日：2021-05-13
申请号：KR1020190144830
申请日：2019-11-13
Applicant: 한국과학기술연구원
IPC: G06F3/0481 , G06F3/00 , G06F3/01
Abstract: 본명세서는손으로제어장치를직접사용하지않더라도 3D 디스플레이에표시된 3D 오브젝트를제어할수 있는장치및 방법을개시한다. 본명세서에따른 D 오브젝트제어장치는, 무안경 3D 디스플레이장치의화면모서리중 적어도 3곳에위치하는복수의화면마커; 사용자의시선방향과같은촬영방향을가지도록사용자의머리에장착된카메라; 및상기카메라를통해촬영된영상내 화면마커들의위치변화를통해상기무안경 3D 디스플레이장치에표시되는 3D 오브젝트를제어하는제어부;를포함할수 있다.
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