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公开(公告)号：US20200209123A1
公开(公告)日：2020-07-02
申请号：US16815749
申请日：2020-03-11
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC: G01N1/40 , B01J20/32 , B01J20/28 , B01J20/26 , B01D71/56 , B01D71/52 , B01D67/00 , C07K1/18 , G01N33/544 , C07F9/38 , C08J7/18 , C07K1/34 , B01D71/44
Abstract: An article that can be used for biomaterial capture comprises(a) a porous substrate; and(b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20190285523A1
公开(公告)日：2019-09-19
申请号：US16433223
申请日：2019-06-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, JR.
IPC: G01N1/40 , C07K1/34 , C08J7/18 , C07F9/38 , G01N33/544 , C07K1/18 , B01D67/00 , B01D71/44 , B01J20/32 , B01J20/28 , B01J20/26 , B01D71/56 , B01D71/52
Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20170217880A1
公开(公告)日：2017-08-03
申请号：US15485636
申请日：2017-04-12
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, JR. , Douglas E. Weiss
IPC: C07C279/12 , B01J20/285 , C08J7/18 , C08F259/08 , C08F283/04
CPC classification number: C07C279/12 , B01D39/1676 , B01J20/285 , C07C277/08 , C07C279/14 , C07C281/16 , C07K1/34 , C08F259/08 , C08F283/04 , C08G69/48 , C08J7/18 , C08J9/283 , C08J9/42 , C08J2327/16 , C08J2377/00 , C12N7/00 , Y02C10/08 , Y10T428/31855
Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
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公开(公告)号：US20170165617A1
公开(公告)日：2017-06-15
申请号：US15444565
申请日：2017-02-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Catherine A. Bothof , George W. Griesgraber , James I. Hembre , Jerald K. Rasmussen
IPC: B01D71/78 , B01D71/56 , C08F255/02 , G01N33/545 , C08J7/18 , B01J20/26 , G01N33/543 , B01D71/40 , C08F283/04
CPC classification number: B01D71/78 , B01D71/40 , B01D71/56 , B01D71/76 , B01D2323/30 , B01D2323/385 , B01D2325/12 , B01J20/261 , B01J20/264 , B01J20/321 , B01J20/3282 , B01J20/3293 , B01J20/3297 , C08F255/02 , C08F283/04 , C08G69/10 , C08G69/48 , C08G73/0206 , C08G73/022 , C08G73/028 , C08J7/18 , C08J2323/06 , C08J2323/12 , C08J2377/00 , C08J2433/14 , C09D177/04 , C09D179/02 , G01N33/54393 , G01N33/545
Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.
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公开(公告)号：US09434829B2
公开(公告)日：2016-09-06
申请号：US14415862
申请日：2013-09-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jerald K. Rasmussen , Catherine A. Bothof
IPC: C08J7/18 , B01J20/26 , B01J20/289 , B01J20/32 , G01N33/543 , C08J7/04 , C09D179/02 , C08G73/02 , C07K1/22 , C07K14/765 , C07K16/00
CPC classification number: B01J20/267 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3276 , B01J20/3278 , B01J20/3282 , C07K1/22 , C07K14/765 , C07K16/00 , C08G73/02 , C08J7/047 , C08J7/18 , C08J2333/24 , C08J2377/06 , C08J2433/14 , C08J2433/24 , C09D4/00 , C09D5/002 , C09D133/24 , C09D179/02 , G01N33/54393
Abstract: Ligand-functionalized substrates are describe that are useful in selectively binding and removing biological materials from biological samples, and methods for preparing the same.
Abstract translation: 描述了可用于选择性结合和从生物样品中除去生物材料的配体官能化底物及其制备方法。
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Patent Agency Ranking
公开(公告)号：US20150203593A1
公开(公告)日：2015-07-23
申请号：US14672871
申请日：2015-03-30
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
IPC: C07K17/08 , B01J20/26 , B01J20/286 , B01D15/38
CPC classification number: C07K17/08 , B01D15/08 , B01D15/3804 , B01D15/3809 , B01J20/264 , B01J20/286 , B01J20/287 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3242 , B01J20/3255 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J39/17 , B01J39/18 , B01J39/20 , B01J41/12 , B01J41/14 , B01J2220/52 , B01J2220/54 , B01J2220/58 , B01J2220/62 , C07K1/22 , C08F271/02
Abstract: Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.
Abstract translation: 描述了含有从固体支持物延伸的接枝链的固体支持物的制品，制造这些制品的方法以及制品的各种用途。 更具体地，接枝链具有可与目标化合物反应或与其相互作用的官能团。 或者，接枝链上的官能团可以与改性剂反应，以提供可与目标化合物反应或与目标化合物相互作用的另一个基团。 接枝的链通过开环的吖内酯基团连接到固体支持物上。 该制品可用于纯化目标化合物或将目标化合物与样品中的其它分子分离。
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公开(公告)号：US08735455B2
公开(公告)日：2014-05-27
申请号：US14058561
申请日：2013-10-21
Applicant: 3M Innovative Properties Company
Inventor： Simon K. Shannon , Catherine A. Bothof , Babu N. Gaddam , Jerald K. Rasmussen , Richard B. Ross
CPC classification number: C07K17/08 , B01D15/08 , B01D15/3804 , B01D15/3809 , B01J20/264 , B01J20/286 , B01J20/287 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3242 , B01J20/3255 , B01J20/3276 , B01J20/3278 , B01J20/328 , B01J39/17 , B01J39/18 , B01J39/20 , B01J41/12 , B01J41/14 , B01J2220/52 , B01J2220/54 , B01J2220/58 , B01J2220/62 , C07K1/22 , C08F271/02
Abstract: Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.
Abstract translation: 描述了含有从固体支持物延伸的接枝链的固体支持物的制品，制造这些制品的方法以及制品的各种用途。 更具体地，接枝链具有可与目标化合物反应或与其相互作用的官能团。 或者，接枝链上的官能团可以与改性剂反应，以提供可与目标化合物反应或与目标化合物相互作用的另一个基团。 接枝的链通过开环的吖内酯基团连接到固体支持物上。 该制品可用于纯化目标化合物或将目标化合物与样品中的其它分子分离。
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公开(公告)号：US20140087445A1
公开(公告)日：2014-03-27
申请号：US14092070
申请日：2013-11-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Catherine A. Bothof , Yi He , Jerald K. Rasmussen , Kannan Seshadri , Clinton P. Waller, JR. , Douglas E. Weiss
CPC classification number: C07C279/12 , B01D39/1676 , B01J20/285 , C07C277/08 , C07C279/14 , C07C281/16 , C07K1/34 , C08F259/08 , C08F283/04 , C08G69/48 , C08J7/18 , C08J9/283 , C08J9/42 , C08J2327/16 , C08J2377/00 , C12N7/00 , Y02C10/08 , Y10T428/31855
Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
Abstract translation: 配体功能化底物，制备配体官能化底物的方法，以及使用官能化底物的方法。
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公开(公告)号：US11237085B2
公开(公告)日：2022-02-01
申请号：US16815749
申请日：2020-03-11
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jerald K. Rasmussen , Catherine A. Bothof , George W. Griesgraber , Semra Colak Atan , James I. Hembre , Robert T. Fitzsimons, Jr.
IPC: B01D71/44 , G01N1/40 , C07K1/34 , C08J7/18 , C07F9/38 , G01N33/544 , C07K1/18 , B01D67/00 , B01D71/52 , B01D71/56 , B01J20/26 , B01J20/28 , B01J20/32
Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.
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公开(公告)号：US20210031152A1
公开(公告)日：2021-02-04
申请号：US16328389
申请日：2017-08-30
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Andrew W. Vail , Semra Colak Atan , Jerald K. Rasmussen , George W. Griesgraber , Catherine A. Bothof
Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the first plurality of pendant groups are different than the second plurality of pendant groups; and wherein a mole ratio of the first plurality of pendant groups to the second plurality of pendant groups is in a range of 95:5 to 5:95.
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