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    ASSAY DEVICES AND METHOD OF DETECTING A TARGET ANALYTE
    21.
    发明公开
    ASSAY DEVICES AND METHOD OF DETECTING A TARGET ANALYTE 审中-公开
    TERVORRICHTUNGEN UND VERFAHREN ZUR DETEKTION EINES ZIELANALYTS

    公开(公告)号：EP3151966A2

    公开(公告)日：2017-04-12

    申请号：EP15794988.4

    申请日：2015-06-08

    Applicant: 3M Innovative Properties Company

    Inventor： ROSCOE, Stephen B. ,  KANG, Myungchan ,  BRUTINEL, Evan D. ,  MILLER, Jesse D. ,  CLINE, Renee K. ,  DAI, Minghua ,  LIU, Hsi-Chou

    IPC: B01L3/00

    CPC classification number: B01L3/5029 ,  B01L3/502 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0478 ,  G01N33/5304

    Abstract: Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.

    Abstract translation: 提供测定装置，包括具有样品入口的容器; 设置在所述容器内的柱塞; 至少一种试剂; 膜连接到柱塞的第一表面; 提供毛细管力的灯芯; 和检测区。 膜包括其中设置亲和成分的靶共轭区。 捕获化合物固定在位于靶共轭区和芯之间的检测区中。 还提供了检测目标分析物的方法，包括提供测定装置; 提供怀疑含有目标分析物的样品; 将样品添加到设备上; 允许样品沿着膜移动直到样品到达检测区域; 通过靶分析物与捕获化合物的反应固定目标分析物; 使固定化的目标分析物与试剂反应以产生可检测的信号; 并检测所产生的信号。

    METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY
    30.
    发明公开
    METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 审中-公开
    检测生物活性的方法和组合物

    公开(公告)号：EP3269822A1

    公开(公告)日：2018-01-17

    申请号：EP17188383.8

    申请日：2011-10-28

    Applicant: 3M Innovative Properties Company

    Inventor： ROSCOE, Stephen B. ,  HALVERSON, Kurt J. ,  MILLER, Jesse D. ,  MOELLER, Stephanie J. ,  BJORK, Jason W.

    IPC: C12Q1/04 ,  G01N21/64

    Abstract: A method of detecting a biological activity, comprising: providing, a sample that may comprise a first biological activity; a first indicator reagent that can be converted by the first biological activity to a first biological derivative; a gelling agent; and a plurality of particles, each particle comprising an organic polymer that receives and retains the first biological derivative, wherein the particles have a mean particle diameter between 0.05 microns and 20 microns; forming a hydrogel comprising the first indicator reagent and the plurality of particles; wherein at least a portion of the plurality of particles is dispersed in the hydrogel or disposed on a major surface of the hydrogel; bringing the sample into fluid communication with a portion of the hydrogel; and detecting the presence or absence of the first biological derivative, wherein the first biological derivative is retained by the plurality of particles; wherein detecting the presence or absence of the first biological derivative comprises detecting a fluorescent first biological derivative or a colored first biological derivative; and wherein the presence of the first biological derivative is indicative of the presence of a first biological activity.

    Abstract translation: 一种检测生物活性的方法，包括：提供可包含第一生物活性的样品; 可以通过第一生物活性转化成第一生物衍生物的第一指示剂; 胶凝剂; 和多个颗粒，每个颗粒包含接收并保留第一生物衍生物的有机聚合物，其中所述颗粒具有0.05微米至20微米的平均粒径; 形成包含所述第一指示剂和所述多个颗粒的水凝胶; 其中所述多个颗粒的至少一部分分散在所述水凝胶中或设置在所述水凝胶的主表面上; 使样品与一部分水凝胶流体连通; 并检测第一生物衍生物的存在或不存在，其中第一生物衍生物被多个颗粒保留; 其中检测所述第一生物衍生物的存在或不存在包括检测荧光第一生物衍生物或有色第一生物衍生物; 并且其中第一生物衍生物的存在指示存在第一生物活性。

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