公开(公告)号：EP1194429B1

公开(公告)日：2005-03-30

申请号：EP00941678.5

申请日：2000-06-23

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  CHEN, Yiyuan ,  HOLLADAY, Mark, W. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  SULLIVAN, James, P. ,  TANG, Rui ,  YI, Lin ,  ZHANG, Henry, Q.

IPC: C07D495/04 ,  C07D215/36 ,  C07D221/04 ,  A61K31/44

CPC classification number: C07D221/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/41 ,  C07C45/63 ,  C07C45/71 ,  C07C205/44 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  C07C47/565 ,  C07C47/55 ,  C07C49/753

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗通过钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。

公开(公告)号：EP1040097B1

公开(公告)日：2004-04-14

申请号：EP98963249.2

申请日：1998-12-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  HOLLADAY, Mark, W. ,  SULLIVAN, James, P. ,  DRIZIN, Irene ,  ZHANG, Henry, Q.

IPC: C07D211/84 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  A61K31/44 ,  A61K31/47 ,  A61K31/38

CPC classification number: C07D221/04 ,  C07C45/298 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。

公开(公告)号：EP1047690B1

公开(公告)日：2004-03-24

申请号：EP98964167.5

申请日：1998-12-18

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  GARVEY, David, S. ,  RYTHER, Keith ,  LEBOLD, Suzanne, A. ,  ELLIOTT, Richard, L. ,  HE, Yun ,  WASIAK, James, T. ,  BAI, Hao ,  DART, Michael, J. ,  EHRLICH, Paul, P. ,  LI, Yihong ,  KINCAID, John, F. ,  SCHKERYANTZ, Jeffrey, M. ,  LYNCH, John, K.

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D455/02 ,  A61K31/44 ,  A61K31/40 ,  A61K31/425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04

Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.

公开(公告)号：EP0970083B1

公开(公告)日：2003-04-16

申请号：EP98907359.8

申请日：1998-02-05

Applicant: Abbott Laboratories

Inventor： WASICAK, James, T. ,  GARVEY, David, S. ,  HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B.

IPC: C07D487/04 ,  A61K31/44

CPC classification number: C07D487/04

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0846114B1

公开(公告)日：2001-12-05

申请号：EP96914786.7

申请日：1996-05-28

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B. ,  HE, Yun

IPC: C07D401/12 ,  A61K31/44

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0973777A1

公开(公告)日：2000-01-26

申请号：EP98913418.4

申请日：1998-04-10

Applicant: Abbott Laboratories

Inventor： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASCIAK, James, T. ,  DAANEN, Jerome, F. ,  LIN, Nan-Horng ,  DART, Michael, J. ,  HE, Yun ,  LI, Yihong

IPC: C07D491/048 ,  A61K31/435 ,  C07D495/04 ,  C07D519/00

CPC classification number: C07D491/04 ,  A61K31/4355

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP0842178A1

公开(公告)日：1998-05-20

申请号：EP96926133.0

申请日：1996-07-25

Applicant: Abbott Laboratories

Inventor： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASICAK, James, T. ,  DAANEN, Jerome, F.

IPC: A61K31 ,  A61P9 ,  A61P25 ,  C07D471 ,  C07D487 ,  C07D491 ,  C07D495 ,  C07D519

CPC classification number: C07D471/04 ,  A61K31/4355 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.